Dr Raphaelle Winsky-Sommerer
Reader in Sleep and Circadian Rhythms
Biography
Biography
Senior Lecturer in Sleep & Circadian Rhythms (since April 2012)Faculty of Health and Medical Sciences, University of Surrey, UK.
Lecturer in Sleep & Circadian Rhythms (October 2009)Faculty of Health and Medical Sciences, University of Surrey, UK.
Research Associate in Sleep & Chronobiology (2004-2009)Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Post-doctoral Research Fellow in Neuroscience (2002-2004)Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Ph.D. Cellular & Molecular Biology, Biology of Ageing (1998-2002)University of René Descartes Paris 5, France. INSERM U549, Paris, France.
Master in Biochemistry & Biology of Ageing (1996-1998)(Master I in Biochemistry; Master II = French DEA in Biology of Ageing)University of Paris 5 & 7, France.
Bachelor of Science in Biochemistry (1994-1996)University of Paris 7, France.
Research interests
Sleep & Circadian Rhythms - Pharmacology of Sleep and WakefulnessCellular and molecular mechanisms underlying the regulation of the daily sleep-wake cycle; Hypnotics and wake-promoting compounds.
Physiology of Neurotransmitter & Neuropeptide SystemsGABAergic transmission and GABAA receptors; adenosinergic system; neuropeptides (i.e., hypocretins/orexins, corticotrophin-releasing hormone, somatostatin/cortistatin, vasopressin, oxytocin).
Disorders of the Central Nervous System - AgingInsomnia; Stress; Addiction; Aging; Neurodegenerative diseases (i.e., Alzheimer's disease)
Funding received
- New Investigator Research Grant- British Biotechnology and Biological Sciences Research Council; BB/I008926/1; 2011-2014; £494,741; 36 months; to R. Winsky-Sommerer (PI).
- Investigator-initiated Research Grant- Pharmaceutical Company; £157,745; 12 months; to R. Winsky-Sommerer (PI), D-J Dijk, S. Archer.
- Feasibility Study Grant- MILES (Models and Mathematics in Life and Social Sciences) University of Surrey; £11,561; to K. Wells, A. Hilton, J. Kilner, R. Winsky-Sommerer.
- Sponsor Award- Grant Seminar Competition 2010-2011, Institute of Advanced Studies, University of Surrey; £2,500 to R. Winsky-Sommerer & D-J Dijk. Two-day international workshop “Multidisciplinary Dissection of Sleep Phenotypes in Animals and Humans”, July 13-14, 2011
- University of Surrey.Research Grant- Forschungskredit 2007 University of Zurich; FK2007#54321101; 2007-2009; CHF100,000; 24 months; to R. Winsky-Sommerer (PI).
Award(s) received
- Award for Outstanding Basic Sleep Research 2009- Swiss Society of Sleep Research, Sleep Medicine and Chronobiology.
Teaching
BMS1023 Chemistry & Mathematics for the BiosciencesBMS1030 BiochemistryBMS2033 Analytical Biochemistry & ChemistryBMS2046 Pathology and MedicineBMS3055 Pharmacology 2BMS3064 Neuroscience 2 - Module organiserMSc Clinical Biochemistry
Supervision of research students (BSc, MSc and PhD students)
Departmental duties
- Divisional Representative on the Faculty of Health & Medical Sciences Ethics Committee (since 2010)
- Organiser of external (national and international) speakers for the monthly Sleep, Chronobiology & Neurodisorders Theme meetings (since 2010)
Affiliations
European Sleep Research Society (ESRS) - Coordinator of the ESRS forum for Women in Sleep ResearchSleep Research Society (SRS)FENS (Federation of European Neuroscience Societies)British Neuroscience Society (BNA)
My publications
Publications
Wright SR, Zanos P, Georgiou P, Yoo JH, Ledent C, Hourani SM, Kitchen I, Winsky-Sommerer R, Bailey A (2015)A critical role of striatal A2A R-mGlu5 R interactions in modulating the psychomotor and drug-seeking effects of methamphetamine., In: ADDICT BIOL WILEY-BLACKWELL PUBLISHING, INC
Zanos P, Georgiou P, Gonzalez LR, Hourani S, Chen Y, Kitchen I, Kieffer BL, Winsky-Sommerer R, Bailey A (2016)Emotional Impairment and Persistent Upregulation of mGlu(5) Receptor following Morphine Abstinence: Implications of an mGlu(5)-MOPr Interaction, In: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY19(7) OXFORD UNIV PRESS
Zanos P, Georgiou P, Wright SR, Hourani SM, Kitchen I, Winsky-Sommerer R, Bailey A (2014)The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice, In: Neuropsychopharmacology39(4)pp. 855-865
Zanos P, Wright SR, Georgiou P, Yoo JH, Hourani SM, Kitchen I, Winsky-Sommerer R, Bailey A, Ledent C (2014)Chronic methamphetamine treatment induces oxytocin receptor up-regulation in the amygdala and hypothalamus via an adenosine A receptor-independent mechanism, In: Pharmacology Biochemistry and Behavior119pp. 72-79
Sahabandu T, Winsky-Sommerer R, Kitchen I, Bailey A, Zanos P, Alshehri M (2011)Persistent brain region-specific upregulation of vasopressin (V1ar) and oxytocin receptors in chronic intermittent escalating dose morphine administration in mice, In: PHARMACOL REP63(1)pp. 252-252 POLISH ACAD SCIENCES INST PHARMACOLOGY
Zanos P, Georgiou P, Metaxas A, Kitchen I, Winsky-Sommerer R, Bailey A (2015)Region-specific up-regulation of oxytocin receptor binding in the brain of mice following chronic nicotine administration, In: NEUROSCIENCE LETTERS600pp. 33-37 ELSEVIER IRELAND LTD
Bettica P, Squassante L, Groeger JA, Gennery B, Winsky-Sommerer R, Dijk DJ (2012)Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia., In: Neuropsychopharmacology37(5)pp. 1224-1233 Nature
Winsky-Sommerer R (2009)Mechanisms Underlying the Effects of GABAA Sedative-Hypnotic Drugs, In: NEUROPSYCHOBIOLOGY59(4)pp. 248-249 KARGER
Winsky-Sommerer R (2009)Role of GABA(A) receptors in the physiology and pharmacology of sleep, In: EUROPEAN JOURNAL OF NEUROSCIENCE29(9)pp. 1779-1794 WILEY-BLACKWELL
Palchykova S, Winsky-Sommerer R, Tobler I (2009)Sleep Deprivation in the Dark Period Does Not Impair Memory in OF1 Mice, In: CHRONOBIOL INT26(4)pp. 682-696 TAYLOR & FRANCIS INC
Loomis Sally (2020)Translational measures of the effects of insufficient sleep on cognition in the rat University of Surrey
Mccarthy Andrew (2020)Novel measures of sleep and wake continuity in rat and man. University of Surrey
Palchykova S, Winsky-Sommerer R, Meerlo P, Durr R, Tobler I (2006)Sleep deprivation impairs object recognition in mice, In: NEUROBIOLOGY OF LEARNING AND MEMORY85(3)pp. 263-271 ACADEMIC PRESS INC ELSEVIER SCIENCE
Tosun Pinar Deniz, Dijk Derk-Jan, Winsky-Sommerer Raphaelle-Valia, Abasolo Daniel (2018)Effects of ageing and sex on complexity in the human sleep EEG: a comparison of three symbolic dynamic analysis methods, In: Complexity Hindawi Publishing
Vyazovskiy VV, Tobler I, Winsky-Sommerer R (2007)Alteration of behavior in mice by muscimol is associated with regional electroencephalogram synchronization, In: NEUROSCIENCE147(3)pp. 833-841 PERGAMON-ELSEVIER SCIENCE LTD
Franco N, Winsky-Sommerer R, Fontana X, Casaroli-Marano R, Ibanez-Sabio MA, Pascual M, Del Rio JA, de Lecea L, Soriano E, Urena JM, La Torre A, Martinez A, Lowenstein E (2005)Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain, In: JOURNAL OF COMPARATIVE NEUROLOGY490(2)pp. 119-132 WILEY-LISS
Huitron-Resendiz S, Winsky-Sommerer R, Sanchez-Alavez M, Wills DN, Xu Y, Civelli O, Henriksen SJ, Criado JR, Reinscheid RK, de Lecea L (2004)Effects of neuropeptide S in the regulation of sleep-wake cycle, In: SLEEP27pp. 32-33
Winsky-Sommerer R, Spier AD, Fabre V, de Lecea L, Criado JR (2004)Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice, In: BRAIN RESEARCH1023(1)pp. 157-162 ELSEVIER SCIENCE BV
Winsky-Sommerer R, Tobler I (2006)Evidence for mechanism of action of the GABA-A receptor agonist THIP in GABA-A receptor delta subunit knockout mice, In: JOURNAL OF SLEEP RESEARCH15pp. 238-238
Nollet M, Stenson G, Martynhak B, Wafford K, Dijk D-J, Winsky-Sommerer R (2014)Characterisation of the development of sleep disturbances in the unpredictable chronic mild stress murine model of major depression, In: JOURNAL OF SLEEP RESEARCH23pp. 78-78
Boutrel B, Kenny PJ, Specio SS, Winsky-Sommerer R, Halfon O, Magistretti PJ, Markou A, Koob GF, de Lecea L (2005)A key role for hypocretin in regulating brain reward function and reinstatement for drug-seeking behavior in rats, In: BEHAVIOURAL PHARMACOLOGY16pp. S60-S60
Winsky-Sommerer R, Boutrel B, de Lecea L (2003)The role of the hypcretinergic system in the integration of networks that dictate the states of arousal, In: DRUG NEWS PERSPECT16(8)pp. 504-512 PROUS SCIENCE, SA
Yasenkov Roman, Winsky-Sommerer Raphaelle (2012)Extrasynaptic GABAA receptors and the local regulation of sleep, In: Extrasynaptic GABAA receptors and the local regulation of sleep
Dijk D-J, Winsky-Sommerer R (2012)Sleep: How much we need and what keeps us awake, In: New Scientist213(2850)pp. iv-v
Winsky-Sommerer R, Boutrel B, de Lecea L (2005)Stress and arousal - The corticotrophin-releasing factor/hypocretin circuitry, In: MOL NEUROBIOL32(3)pp. 285-294 HUMANA PRESS INC
Dijk D-J, Winsky-Sommerer R (2012)Sleep: What it is and what it's for, In: New Scientist213(2850)pp. ii-iii
Stenson GM, Nollet M, Winsky-Sommerer R (2014)Characterisation of the role of extrasynaptic GABA(A) receptors in sleep and mood regulation in a rodent model, In: JOURNAL OF SLEEP RESEARCH23pp. 256-256
Dissel S, Angadi V, Kirszenblat L, Suzuki Y, Donlea J, Klose M, Koch Z, English D, Winsky-Sommerer R, Van Swinderen B, Shaw PJ (2015)Sleep restores behavioral plasticity to drosophila mutants, In: Current Biology25(10)pp. 1270-1281 Elsevier
Winsky-Sommerer R (2008)New insights from basic animal research on GABAA receptor mediated inhibition to understand selective pharmacological profiles of hypnotics, In: JOURNAL OF SLEEP RESEARCH17pp. 58-58
Dijk D-J, Winsky-Sommerer R (2012)Sleep: The way we snooze now, In: New Scientist213(2850)pp. vi-vii
Conti B, Sugama S, Lucero J, Winsky-Sommerer R, Wirz SA, Maher P, Andrews Z, Barr AM, Morale MC, Paneda C, Pemberton J, Gaidarova S, Behrens MM, Beal F, Sanna PP, Horvath TL, Bartfai T (2005)Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity, In: JOURNAL OF NEUROCHEMISTRY93(2)pp. 493-501 BLACKWELL PUBLISHING LTD
Winsky-Sommerer R, Knapman A, Tobler I (2008)Sleep and sleep regulation in mice lacking the GABA-A receptor A3-subunit, In: SLEEP31pp. A17-A18
Nollet Mathieu, Hicks Harriet, McCarthy Andrew P., Wu Huihai, Moller-Levet Carla S., Laing Emma E., Malki Karim, Lawless Nathan, Wafford Keith A., Dijk Derk-Jan, Winsky-Sommerer Raphaelle (2018)REM sleep: unique associations with corticosterone regulation, apoptotic pathways and behavior in chronic stress in mice, In: Proceedings of the National Academy of Sciences116(7)pp. 2733-2742 National Academy of Sciences of the United States of America
Huitron-Resendiz S, Clark SD, Sanchez-Alavez M, Winsky-Sommerer R, Civelli O, Nothacker HP, Henriksen SJ, Criado JR, de Lecea L (2003)Effects of urotensin-II in the regulation of REM sleep, In: SLEEP26pp. A47-A48
Winsky-Sommerer R, Huitron-Resendiz S, Sanchez-Alavez M, Slaght K, Henriksen SJ, Criado JR, de Lecea L (2003)Effect of the endogenous GPR7/8 ligand (neuropeptide W) on sleep/wakefulness, In: SLEEP26pp. A49-A49
Cervera P, Videau C, Viollet C, Petrucci C, Lacombe J, Winsky-Sommerer R, Csaba Z, Helboe L, Daumas-Duport C, Reubi JC, Epelbaum J (2002)Comparison of somatostatin receptor expression in human gliomas and medulloblastomas, In: JOURNAL OF NEUROENDOCRINOLOGY14(6)pp. 458-471 BLACKWELL PUBLISHING LTD
Winsky-Sommerer R, Yamanaka A, Sakurai T, Roberts AJ, Kilduff TS, de Lecea L (2004)Interaction between the corticotropin-releasing-factor system and hypocretins: Components mediating the stress response, In: SLEEP27pp. 23-23
de Lecea L, Winsky-Sommerer R, Suzuki C, Xu Y, Reinscheid R (2005)Neuropeptide S projects to arousal nuclei, In: SLEEP28pp. A10-A10
Kovacs Z, Tobler I, Winsky-Sommerer R (2008)A role for GABAA alpha 4-subunit-containing receptors in sleep regulation?, In: JOURNAL OF SLEEP RESEARCH17pp. 203-204
Kovacs Z, Tobler I, Winsky-Sommerer R (2009)Role of the GABAA Alpha4-Subtype in Sleep and Sleep Regulation, In: Neuropsychobiology: international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, biological psychology, pharmacopsychology and pharmacoelectroencephalography4(59)pp. 267-267
Kovacs Z, Tobler I, Winsky-Sommerer R (2009)DECIPHERING THE ROLE OF THE GABA-A ALPHA4-SUBTYPE IN SLEEP, In: SLEEP32pp. A14-A15
Paneda C, Winsky-Sommerer R, Boutrel B, de Lecea L (2005)The corticotropin-releasing factor-hypocretin connection: Implications in stress response and addiction, In: DRUG NEWS PERSPECT18(4)pp. 250-255 PROUS SCIENCE, SA
Leschziner G.D., Morrell M.J., Rosenzweig I., Polsek D., Gildeh N., Turkheimer F., Cash D., Winsky-Sommerer R., Williams S.C.R. (2018)Obstructive sleep apnoea and Alzheimer’s disease: In search of shared pathomechanisms, In: Neuroscience & Biobehavioral Reviews86pp. 142-149 Elsevier
Winsky-Sommerer R, Vesely M, Tobler I (2006)Effects of the GABA-A receptor agonist THIP on the sleep EEG of GABA-A receptor delta subunit knockout mice, In: SLEEP29pp. A21-A21
Dissel S, Klose M, Donlea J, Cao L, English D, Winsky-Sommerer Raphaelle-Valia, van Swinderen B, Shaw PJ (2016)Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease, In: Neurobiology of Sleep and Circadian Rhythms2pp. 15-26 Elsevier
Winsky-Sommerer Raphaelle, de Oliveira Paula, Loomis Sally, Wafford Keith, Dijk Derk-Jan, Gilmour Gary (2019)Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer’s disease and schizophrenia: Insights from studies in patient populations and animal models, In: Neuroscience & Biobehavioral Reviews97pp. 112-137 Elsevier
Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC, Lucero J, Brownell S, Fabre V, Huitron-Resendiz S, Henriksen S, Zorrilla EP, de Lecea L, Bartfai T (2006)Transgenic mice with a reduced core body temperature have an increased life span, In: SCIENCE314(5800)pp. 825-828 AMER ASSOC ADVANCEMENT SCIENCE
Levine AS, Winsky-Sommerer R, Huitron-Resendiz S, Grace MK, de Lecea L (2005)Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake, In: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY288(6)pp. R1727-R1732 AMER PHYSIOLOGICAL SOC
Navarro-Sanchis C, Brock O, Winsky-Sommerer Raphaelle-Valia, Thuret S (2017)Modulation of adult hippocampal neurogenesis by sleep: Impact on mental health, In: Frontiers in Neural Circuits1174 Frontiers Media
Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L (2004)Interaction between the corticotropin-releasing factor system and hypocretins (Orexins): A novel circuit mediating stress response, In: JOURNAL OF NEUROSCIENCE24(50)pp. 11439-11448 SOC NEUROSCIENCE
Winsky-Sommerer R, Knapman A, Fedele DE, Schofield CM, Vyazovskiy VV, Rudolph U, Huguenard JR, Fritschy J-M, Tobler I (2008)Normal sleep homeostasis and lack of epilepsy phenotype in GABA(A) receptor alpha 3 subunit-knockout mice, In: NEUROSCIENCE154(2)pp. 595-605 PERGAMON-ELSEVIER SCIENCE LTD
Loomis Sally, Mccarthy Andrew, Dijk Derk-Jan, Gilmour Gary, Winsky-Sommerer Raphaelle (2020)Food restriction induces functional resilience to sleep restriction in rats, In: Sleep Oxford University Press (OUP)
Palchykova S, Winsky-Sommerer R, Shen H-Y, Boison D, Gerling A, Tobler I (2010)Manipulation of Adenosine Kinase Affects Sleep Regulation in Mice, In: JOURNAL OF NEUROSCIENCE30(39)pp. 13157-13165 SOC NEUROSCIENCE
McCarthy A, Loomis S, Eastwood B, Wafford KA, Winsky-Sommerer Raphaelle-Valia, Gilmour G (2016)Modelling maintenance of wakefulness in rats: comparing potential non-invasive sleep restriction methods and their effects on sleep and attentional performance, In: Journal of Sleep Research26(2)pp. 179-187 Wiley
Hasan S, Winsky-Sommerer R, Dijk D-J, Archer SN (2012)Sleep in transgenic mouse models for a polymorphism in the human PER3 gene, In: JOURNAL OF SLEEP RESEARCH21pp. 79-79
Archer SN, Hasan S, van der Veen DR, Winsky-Sommerer R, Hogben A, Laing EE, Koentgen F, Dijk DJ (2014)A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism., In: FASEB J
Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF, Shen HY, Lazarus M (2011)Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens., In: J Neurosci31(27)pp. 10067-10075 Society for Neuroscience
Grouselle D, Winsky-Sommerer R, David JP, Delacourte A, Dournaud P, Epelbaum J (1998)Loss of somatostatin-like immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele, In: NEUROSCIENCE LETTERS255(1)pp. 21-24 ELSEVIER SCI IRELAND LTD
Hasan S, van der Veen DR, Winsky-Sommerer R, Dijk DJ, Archer SN (2011)Altered sleep and behavioral activity phenotypes in PER3-deficient mice., In: Am J Physiol Regul Integr Comp Physiol
Tosun Pinar Deniz, Abasolo Daniel Emilio, Stenson Gillian, Winsky-Sommerer Raphaelle-Valia (2018)Characterisation of the Effects of Sleep Deprivation on the Electroencephalogram using Permutation Lempel-Ziv Complexity, a non-linear analysis tool, In: Entropy19(12)e19120673pp. 1-14 MDPI
Tosun Pinar Deniz, Dijk Derk-Jan, Winsky-Sommerer Raphaelle, Abasolo Daniel (2019)Effects of Ageing and Sex on Complexity in the Human Sleep EEG: A Comparison of Three Symbolic Dynamic Analysis Methods., In: Natella Roberto (eds.), Complexity20199254309pp. 1-12 Hindawi Publishing Corporation
Winsky-Sommerer R, Vyazovskiy VV, Homanics GE, Tobler I (2007)The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A) delta-subunit-containing receptors, In: EUROPEAN JOURNAL OF NEUROSCIENCE25(6)pp. 1893-1899 WILEY-BLACKWELL
Winsky-Sommerer R, Grouselle D, Rougeot C, Laurent V, David JP, Delacourte A, Dournaud P, Seidah NG, Lindberg I, Trottier S, Epelbaum J (2003)The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease, In: NEUROSCIENCE122(2)pp. 437-447 PERGAMON-ELSEVIER SCIENCE LTD