Alistair Nun (Guy Foundation)
18 Jan 2024
A space Odyssey… From the origins of life to disease, what might quantum mechanics and thermodynamics tell us?
It can be said that in trying to understand steam engines, thermodynamics was born and in trying to comprehend light, and the Universe, quantum mechanics was developed. Although many think these fields are the domains of physicists and mathematicians, it has long been realised that they must also explain how life works, which means that they must overlap with biology, and at some level, help to explain the “hard questions”, such as the origins of life, ageing and disease, consciousness and are we alone in the Universe. Indeed, it could even be said, somewhat counter-intuitively, that biology may provide us with a deeper understanding of quantum mechanics and thermodynamics. However, despite a (slow) rise in interest in the field of “quantum biology”, many biologists and physicists are still wary about dipping their toes into these apparently scary different worlds with often totally alien languages. As is often the case, a common challenge can sometimes bring different folk together, even if they originally didn’t see the commonality. One approach could well be medicine, which although it has made great progress, is still limited as there are still big holes in our understanding. However, medicine itself also often makes big strides when it is faced with a particular challenge, such as was faced hundreds of years ago when sailing ships began exploring the globe. The crews often got very ill; it was soon realised that a healthy diet, and when visiting different countries, local remedies could make a big difference. Today, we may be facing something similar as humankind, and our associated organisms, explore space. Astronauts, and cosmonauts, appear to be developing an accelerated ageing phenotype; this could become a big issue on longer space missions, say, to Mars. In this talk, I explore the potential of both thermodynamics and quantum mechanics at a very basic level (no equations!), in helping us understand why this may be happening, in particular, why starting from the origins of life may provide insight, and how the mitochondrion, the ancestor of the earliest forms of life, could be a good “canary in the (metabolic) coal mine”. A key tenet to hold here is that life is electrical.