12 noon - 1pm
Thursday 3 May 2018

The economics of bacterial gene expression

Jose Gimenez (Surrey) will be speaking.

Room 39AA04
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Speakers

Abstract

The cellular resources required for gene expression are limited in bacterial cells. Owing to this, the expression of a particular gene can affect the activity of another seemingly unconnected gene and it has been shown that this coupling can be described by linear manifolds.

We combine experimental work and mathematical models to understand how these couplings emerge and how can they be alleviated to improve the performance of synthetic genetic circuits and pathways. In particular, we have investigated the effect of producing partitions of ribosomes that can be allocated differentially to specific mRNAs of interest.