Dr Emma Laing


Senior Lecturer in Bioinformatics, Head of Bioinformatics
BSc, MSc, PhD, PGCAP
+44 (0)1483 689626
10 SE 00
8am - 4pm

Biography

Research

Research interests

My teaching

My publications

Publications

Beste DJV, Laing E, Bonde B, Avignone-Rossa C, Bushell ME, McFadden JJ (2007)Transcriptomic analysis identifies growth rate modulation as a component of the adaptation of mycobacteria to survival inside the macrophage, In: J BACTERIOL189(11)pp. 3969-3976 AMER SOC MICROBIOLOGY
Archer SN, Laing EE, Möller-Levet CS, van der Veen DR, Bucca G, Lazar AS, Santhi N, Slak A, Kabiljo R, von Schantz M, Smith CP, Dijk DJ (2014)Mistimed sleep disrupts circadian regulation of the human transcriptome., In: Proc Natl Acad Sci U S A
Christou Skevoulla, Wehrens Sophie M T, Isherwood Cheryl, Moller-Levet Carla S, Wu Huihai, Revell Victoria L, Bucca Giselda, Skene Debra J, Laing Emma E, Archer Simon N, Johnston Jonathan D (2019)Circadian regulation in human white adipose tissue revealed by transcriptome and metabolic network analysis, In: Scientific Reports Nature Research
Salerno P, Persson J, Bucca G, Laing E, Ausmees N, Smith CP, Flärdh K (2013)Identification of new developmentally regulated genes involved in Streptomyces coelicolor sporulation., In: BMC Microbiol13pp. 281-?
Rico S, Santamaría RI, Yepes A, Rodríguez H, Laing E, Bucca G, Smith CP, Díaz M (2014)Deciphering the regulon of the Streptomyces coelicolor AbrC3, a positive response regulator of antibiotic production., In: Appl Environ Microbiol American Society for Microbiology
Bonde BK, Beste DJV, Laing E, Kierzek AM, McFadden J (2011)Differential Producibility Analysis (DPA) of Transcriptomic Data with Metabolic Networks: Deconstructing the Metabolic Response of M. tuberculosis, In: PLOS COMPUTATIONAL BIOLOGY7(6)ARTN epp. ?-? PUBLIC LIBRARY SCIENCE
Sooriakumaran P, Macanas-Pirard P, Bucca G, Henderson A, Langley SE, Laing RW, Smith CP, Laing EE, Coley HM (2009)A gene expression profiling approach assessing celecoxib in a randomized controlled trial in prostate cancer., In: Cancer Genomics Proteomics6(2)pp. 93-99 International Institute of Anticancer Research (IIAR)
Bucca G, Laing E, Mersinias V, Allenby N, Hurd D, Holdstock J, Brenner V, Harrison M, Smith CP (2009)Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon, In: GENOME BIOLOGY10(1)ARTN Rpp. ?-? BIOMED CENTRAL LTD
Lewis RA, Shahi SK, Laing E, Bucca G, Efthimiou G, Bushell M, Smith CP (2011)Genome-wide transcriptomic analysis of the response to nitrogen limitation in Streptomyces coelicolor A3(2)., In: BMC Res Notes4pp. 78-?
Laing E, Mersinias V, Smith CP, Hubbard SJ (2006)Analysis of gene expression in operons of Streptomyces coelicolor, In: GENOME BIOLOGY7(6)ARTN Rpp. ?-? BIOMED CENTRAL LTD
Laing Emma, Johnston Jonathan, Moller-Levet Carla, Bucca G, Smith CP, Dijk Derk-Jan, Archer Simon (2015)Exploiting human and mouse transcriptomic data: Identification of circadian genes and pathways influencing health, In: BioEssays37(5)pp. 544-556 Wiley
Laing Emma, Moller-Levet Carla, Dijk Derk-Jan, Archer Simon (2018)Identifying and validating blood mRNA biomarkers for acute and chronic insufficient sleep in humans: a machine learning approach, In: Sleep42(1)zsy186pp. 1-18 Oxford University Press
Hesketh A, Bucca G, Laing E, Flett F, Hotchkiss G, Smith CP, Chater KF (2007)New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures, In: BMC GENOMICS8ARTN 2pp. ?-? BIOMED CENTRAL LTD
Thomas SA, jin Y, Laing E, Smith CP (2016)Modeling Dynamic Gene Expression in Streptomyces Coelicolor: Comparing Single and Multi-Objective Setups, In: Iba H, Noman N (eds.), Evolutionary Computation in Gene Regulatory Network Research(7) John Wiley & Sons
Thomas SA, Jin Y, Laing E, Smith CP (2013)Reconstructing regulatory networks in Streptomyces using evolutionary algorithms, In: 2013 13th UK Workshop on Computational Intelligence, UKCI 2013pp. 24-30
Bucca Giselda, Pothi Radhika, Hesketh Andrew, Moller-Levet Carla, Hodgson David A, Laing Emma, Stewart Graham, Smith Colin (2018)Translational control plays an important role in the adaptive heat-shock response of Streptomyces coelicolor., In: Nucleic Acids Research46(11)pp. 5692-5703 Oxford University Press
Nollet Mathieu, Hicks Harriet, McCarthy Andrew P., Wu Huihai, Moller-Levet Carla S., Laing Emma E., Malki Karim, Lawless Nathan, Wafford Keith A., Dijk Derk-Jan, Winsky-Sommerer Raphaelle (2018)REM sleep: unique associations with corticosterone regulation, apoptotic pathways and behavior in chronic stress in mice, In: Proceedings of the National Academy of Sciences116(7)pp. 2733-2742 National Academy of Sciences of the United States of America
Wallqvist Anders, López-Agudelo Víctor A., Mendum Tom A., Laing Emma, Wu Huihai, Baena Andres, Barrera Luis F., Beste Dany J. V., Rios-Estepa Rigoberto (2020)A systematic evaluation of Mycobacterium tuberculosis Genome-Scale Metabolic Networks, In: PLOS Computational Biology16(6)e1007533 Public Library of Science
Archer SN, Laing EE, Moller-Levet CS, van der Veen DR, Bucca G, Lazar AS, Lo JCY, Santhi N, Slak A, Kabiljo R, von Schantz M, Smith CP, Dijk DJ (2014)Mistimed sleep disrupts the circadian regulation of the human transcriptome, In: JOURNAL OF SLEEP RESEARCH23pp. 15-15
Möller-Levet CS, Archer SN, Bucca G, Laing EE, Slak A, Kabiljo R, Lo JC, Santhi N, von Schantz M, Smith CP, Dijk DJ (2013)Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome., In: Proc Natl Acad Sci U S A110(12)pp. E1132-E1141
Iadevaia Valentina, Wouters Maikel D., Kanitz Alexander, Matia-González Ana M., Laing Emma E., Gerber André P. (2020)Tandem RNA isolation reveals functional rearrangement of RNA-binding proteins on CDKN1B/p27Kip1 3'UTRs in cisplatin treated cells, In: RNA Biology17(1)pp. 33-46 Taylor & Francis
Hasan AH, Lin Y-F, Kime L, Ruiz-Larrabeiti O, Urem M, Bucca G, Mamanova L, Laing EE, van Wezel GP, Smith CP, Kaberdin VR, McDowall KJ, Romero DA (2014)A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide-resolution transcription maps produced in parallel by global and differential RNA sequencing, In: MOLECULAR MICROBIOLOGY94(5)pp. 963-987 WILEY-BLACKWELL
Hesketh A, Bucca G, Laing E, Flett F, Hotchkiss G, Smith CP, Chater KF (2007)New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures, In: BMC GENOMICS8261pp. ?-? BIOMED CENTRAL LTD
Matia-González AM, Laing Emma, Gerber Andre (2015)Conserved mRNA-binding proteomes in eukaryotic organisms, In: Nature Structural and Molecular Biology22(12)pp. 1027-1033 NATURE PUBLISHING GROUP
Beste DJV, Laing E, Bonde B, Avignone-Rossa C, Bushell ME, McFadden JJ (2007)Transcriptomic analysis identifies growth rate modulation as a component of the adaptation of mycobacteria to survival inside the macrophage, In: JOURNAL OF BACTERIOLOGY189(11)pp. 3969-3976 AMER SOC MICROBIOLOGY
Van Der Veen Daan, Laing Emma, Bae Sung-Eun, Johnston Jonathan, Dijk Derk-Jan, Archer Simon (2020)A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3, In: Frontiers in Molecular Neuroscience13(15) Frontiers Media
Archer SN, Hasan S, van der Veen DR, Winsky-Sommerer R, Hogben A, Laing EE, Koentgen F, Dijk DJ (2014)A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism., In: FASEB J
Laing Emma, Moller-Levet Carla, Poh Norman, Santhi Nayantara, Archer Simon, Dijk Derk-Jan (2017)Blood transcriptome based biomarkers for human circadian phase, In: eLifepp. 1-26 eLife Sciences Publications Ltd