Isaiah Joseph Ting


Postgraduate Research Student
BSc (Hons)

My research project

University roles and responsibilities

  • STARS Undergraduate Mentor
  • FHMS Associate Theme Champion (Chronobiology and Sleep)
  • FHMS laboratory demonstrator

    My qualifications

    BSc (Hons) Biochemistry
    University of Surrey

    Affiliations and memberships

    Biochemical Society
    Postgraduate member

    Research

    Research interests

    My teaching

    My publications

    Highlights

    The Lost Connection Between the Filipino People and our Past - the Effects of Colonialism in this Generation By Isaiah Ting and Hazel Ting

    https://www.thestagsurrey.co.uk/filipino/ 

    I Can Speak English, You Know By Isaiah Ting

    https://www.thestagsurrey.co.uk/everyday-racism/

    Publications

    Yadira Pastor, Isaiah Ting, Ana Luisa, Martínez Juan, Manuel Irache, Carlos Gamazo (2020). Intranasal delivery system of bacterial antigen using thermosensitive hydrogels based on a Pluronic-Gantrez conjugate
    View abstract View full publication
    Thermosensitive hydrogels have been studied as feasible needle-avoidance alternative to vaccine delivery. In this work, we report the development of a new thermal-sensitive hydrogel for intranasal vaccine delivery. This delivery system was formulated with a combination of the polymer Gantrez® AN119 and the surfactant Pluronic® F127 (PF127), with a high biocompatibility, biodegradability and immunoadjuvant properties. outer membrane vesicles were used as the antigen model. A stable and easy-to-produce thermosensitive hydrogel which allowed the incorporation of the OMV-antigenic complex was successfully synthetized. A rapid gel formation was achieved at body temperature, which prolonged the OMV-antigens residence time in the nasal cavity of BALB/c mice when compared to intranasal delivery of free-OMVs. In addition, the bacterial antigens showed a fast release profile from the hydrogel , with a peak at 30 min of incubation at 37 °C. Hydrogels appeared to be non-cytotoxic in the human epithelial HeLa cell line and nose epithelium as well, as indicated by the absence of histopathological features. Immunohistochemical studies revealed that after intranasal administration the OMVs reached the nasal associated lymphoid tissue. These results support the use of here described thermosensitive hydrogels as a potential platform for intranasal vaccination.
    Shigella flexneriin vitro