Placeholder image for staff profiles

Jane Lyle


Postgraduate Research Student
+44 (0)1483 683024
17 AA 04

Academic and research departments

Department of Mathematics.

My publications

Publications

Philip Aston, Jane Lyle, Esther Bonet-Luz, Christopher Huang, Yanmin Zhang, Kamalan Jeevaratnam, Manasi Nandi (2020)Deep Learning Applied to Attractor Images Derived from ECG Signals for Detection of Genetic Mutation, In: Proceedings of International Conference in Computing in Cardiology 2019 (CinC 2019)46097 Institute of Electrical and Electronics Engineers (IEEE)
The aim of this work is to distinguish between wild-type mice and Scn5a +/- mutant mice using short ECG signals. This mutation results in impaired cardiac sodium channel function and is associated with increased ventricular arrhythmogenic risk which can result in sudden cardiac death. Lead I and Lead II ECG signals from wild-type and Scn5a +/- mice are used and the mice are also grouped as female/male and young/old.We use our novel Symmetric Projection Attractor Reconstruction (SPAR) method to generate an attractor from the ECG signal using all of the available waveform data. We have previously manually extracted a variety of quantitative measures from the attractor and used machine learning to classify each animal as either wild-type or mutant. In this work, we take the attractor images and use these as input to a deep learning algorithm in order to perform the same classification. As there is only data available from 42 mice, we use a transfer learning approach in which a network that has been pretrained on millions of images is used as a starting point and the last few layers are changed in order to fine tune the network for the attractor images.The results for the transfer learning approach are not as good as for the manual features, which is not too surprising as the networks have not been trained on attractor images. However, this approach shows the potential for using deep learning for classification of attractor images.
JANE VICTORIA LYLE, Manasi Nandi, PHILIP JAMES ASTON (2020)Investigating the Response to Dofetilide with Symmetric Projection Attractor Reconstruction of the Electrocardiogram, In: Proceedings of International Conference in Computing in Cardiology 2019 (CinC 2019)46073pp. 1-4 Institute of Electrical and Electronics Engineers (IEEE)
The aim of this study is a preliminary investigation into the application of our novel Symmetric Projection Attractor Reconstruction (SPAR) method to the electrocardiogram (ECG) signals of individuals treated with the cardioactive drug dofetilide. We show that our SPAR technique correlates with standard assessment, and is also able to discriminate gender from the ECG response to dofetilide more accurately than the standard metrics.
Esther Bonet-Luz, Jane V. Lyle, Christopher L.-H. Huang, Yanmin Zhang, Manasi Nandi, Kamalan Jeevaratnam, Philip J. Aston (2020)Symmetric Projection Attractor Reconstruction analysis of murine electrocardiograms Retrospective prediction of Scn5a+⁄- genetic mutation attributable to Brugada syndrome, In: Heart Rhythm1(5)pp. 368-375 Elsevier
Background Life-threatening arrhythmias resulting from genetic mutations are often missed in current electrocardiogram (ECG) analysis. We combined a new method for ECG analysis that uses all the waveform data with machine learning to improve detection of such mutations from short ECG signals in a mouse model. Objective We sought to detect consequences of Na+ channel deficiencies known to compromise action potential conduction in comparisons of Scn5a+/- mutant and wild-type mice using short ECG signals, examining novel and standard features derived from lead I and II ECG recordings by machine learning algorithms. Methods Lead I and II ECG signals from anesthetized wild-type and Scn5a+/- mutant mice of length 130 seconds were analyzed by extracting various groups of features, which were used by machine learning to classify the mice as wild-type or mutant. The features used were standard ECG intervals and amplitudes, as well as features derived from attractors generated using the novel Symmetric Projection Attractor Reconstruction method, which reformulates the whole signal as a bounded, symmetric 2-dimensional attractor. All the features were also combined as a single feature group. Results Classification of genotype using the attractor features gave higher accuracy than using either the ECG intervals or the intervals and amplitudes. However, the highest accuracy (96%) was obtained using all the features. Accuracies for different subgroups of the data were obtained and compared. Conclusion Detection of the Scn5a+/- mutation from short mouse ECG signals with high accuracy is possible using our Symmetric Projection Attractor Reconstruction method.
Jane Lyle, Peter H. Charlton, Esther Bonet Luz, Gary Chaffey, Mark Christie, Manasi Nandi, Philip Aston (2017)Beyond HRV: Analysis of ECG Signals Using Attractor Reconstruction, In: Computing in Cardiology 201744 Computing in Cardiology
Attractor reconstruction analysis has previously been applied to analyse arterial blood pressure and photoplethysmogram signals. This study extends this novel technique to ECG signals. We show that the method gives high accuracy in identifying gender from ECG signals, performing significantly better than the same classification by interval measures.