
About
My research project
Computational Modelling of Cerebrospinal Fluid Dynamics is Dogs with Brachycephaly associated Chiari-like Malformation and SyringomyeliaIn mammals, cerebrospinal fluid facilitates metabolite distribution within the brain, regulated by a complex system of fluid channels within the central nervous system. As such, flow dysregulation can be extremely detrimental to, and even incompatible with, life. Dysregulation may be induced by CSF associated disorders such as Chiari-like malformation and syringomyelia, of which brachycephalic dog breeds are particularly predisposed. In these cases, there is no effective long-term pharmaceutical treatment, and surgical intervention is associated with poor long-term postoperative outcome. There exists no consensus on surgical treatment modality. This project aims to develop a computational model of the entire cranio-spinal CSF cavity to simulate flow dynamics, and the response of diseased models to various surgical interventions.
Supervisors
In mammals, cerebrospinal fluid facilitates metabolite distribution within the brain, regulated by a complex system of fluid channels within the central nervous system. As such, flow dysregulation can be extremely detrimental to, and even incompatible with, life. Dysregulation may be induced by CSF associated disorders such as Chiari-like malformation and syringomyelia, of which brachycephalic dog breeds are particularly predisposed. In these cases, there is no effective long-term pharmaceutical treatment, and surgical intervention is associated with poor long-term postoperative outcome. There exists no consensus on surgical treatment modality. This project aims to develop a computational model of the entire cranio-spinal CSF cavity to simulate flow dynamics, and the response of diseased models to various surgical interventions.