The interplay between the Mitochondrial Unfolded Protein Response (UPRmt) and the Integrated Stress Repsonse (ISR) in the stressed heart

Biography

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I completed my PhD studies under the supervision of Drs M. Bootman and L. Roderick at the University of Cambridge. My thesis described the hormonal regulation of calcium signalling and contractility in adult cardiomyocytes.

I then undertook my postdoctoral research at King’s College London in Prof Ajay Shah’s lab. During this period, I investigated the protective role of the NRF2 transcription factor in the overloaded heart. Additionally, I explored the significance of the mitochondrial unfolded protein response (UPRmt) during cardiac stress. This research led to the first publication that described the protective role of the ATF5-dependent UPRmt activation in a pressure-overloaded murine and human heart.

In 2020, I joined the University of Surrey as a lecturer in cardiovascular sciences. Our research centers on understanding the mechanisms that maintain mitochondrial homeostasis in the stressed heart. We have a specific focus on the signalling events that regulate the cardioprotective effects of the mitochondrial stress response during adverse conditions. Our goal is to identify novel therapeutic strategies against heart disease and other conditions linked to mitochondrial dysfunction.

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