My research project
Disentangling the role of Ascaris β-tubulin isotypes in the emergence of anthelmintic resistance
My work focuses on the development of anthelmintic resistance in Ascaris. Ascaris are parasitic roundworms that inhabit the small intestines of humans and pigs. there are approximately 1 billion people infected with Ascaris with the majority of these being in the developing world. Ascariasis is the disease caused by infection from these parasites and is listed as a neglected tropical disease (NTD). I have been investigating the beta-tubulin genes and the role that they play in the development of drug resistance. Using genomic assemblies I have identified the beta-tubulin genes and their expression profiles and used in silico methods to model how mutations in these genes can alter drug interactions and lead to resistance.
Jones, B.P., Norman, B.F., Borrett, H.E. et al. Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale. Sci Rep 10, 2480 (2020).
Betson M, Alonte AJI, Ancog RC, et al. Zoonotic transmission of intestinal helminths in southeast Asia: Implications for control and elimination. Adv Parasitol. 2020;108:47-131.