Bruce Griffin

Professor Bruce Griffin


Professor of Nutritional Metabolism
BSc PhD RNutr
+44 (0)1483 689724
32 PG 00

Biography

Biography

Professor Griffin is a biomedical scientist with expertise in lipid metabolism, nutritional biochemistry and cardiovascular disease. After gaining a BSc with first class honours in medical laboratory science at Portsmouth Polytechnic in 1984, he undertook a PhD on the effects of exercise and diet on human plasma lipoproteins at the University of Aberdeen, under the supervision of Professor Ronald Maughan and Dr Roy Skinner (1988). This was followed by postdoctoral research in Pathological Biochemistry at Glasgow Royal Infirmary with Professors Jim Shepherd and Chris Packard. Since 1994, he has held academic posts as a Lecturer, Senior lecturer, Reader and Professor of Nutritional Metabolism at the University of Surrey. He is a teacher of undergraduate dietitians, nutritionists and food scientists, and Masters students in nutritional medicine and human nutrition. He is active as a researcher and external speaker in human nutrition in relation to cardiovascular health, and has published widely on the topics of blood lipids, dietary macronutrients and cardiovascular disease. Professor Griffin's research has been supported by grants from the Medical Research Council, British Heart Foundation, Department for Environment Food and Rural Affairs, Food Standards Agency, Biotechnology and Biological Sciences Research Council, and various industries.  

Research interests

Role of human nutrition in the pathophysiology of cardiovascular disease; effects of diet on blood lipids and lipoprotein metabolism; genetic and environmental determinants of cardiovascular atherosclerosis.

Research grants 

1991: Susceptibility of LDL subfractions to oxidative modification in relation to coronary heart disease. (MRC) 

1991: Role of antioxidants and dietary fatty acids in the oxidative modification of human plasma LDL (MAFF)

1993: Low density lipoprotein carbohydrate as a determinant of LDL subfraction metabolism (MRC)         

1996: Can the metabolic effects of dietary n-3 PUFA be explained by changes in the expression of lipase genes in adipose tissue? (BBSRC)

1997: The influence of dietary n-3 PUFA on the structure, function and metabolism of TAG-rich lipoproteins in healthy individuals. (BBSRC)

1998: Importance of alpha-linolenic acid as a source of long chain n-3 PUFA and its influence on risk factors of cardiovascular disease. (UK Food Standards Agency)

2000: Vitamin E biokinetics and metabolism in dyslipidaemia.(BHF)

2000: Quantification of the optimal n-6 / n-3 ratio in the UK diet. The 'OPTILIP' study (UK Food Standards Agency)

2003: Effect of low glycaemic index foods on blood lipids in type 2 diabetes 

2003: Impact of the amount and composition of dietary fat and carbohydrate on metabolic syndrome and CVD risk; The 'RISCK' Study. (UK Food Standards Agency)

2005: Effects of increased egg consumption on a weight-reducing diet on blood cholesterol & related biomarkers of CHD risk (British Egg Information Service)

2008: Dietary intervention study to determine the effects of prawns on serum cholesterol and related biomarkers of CHD risk (DEFRA)

2009: How does dietary carbohydrate influence the formation of an atherogenic lipoprotein phenotype? (BBSRC)

2014: Risk-assessed exercise and diet intervention for men with prostate cancer. (Prostate Cancer UK)

2016: Mechanisms to explain variation in the serum low density lipoprotein cholesterol response to dietary saturated fat. (BBSRC)

Research collaborations

  • University of Reading
  • Kings College London
  • Imperial College London
  • MRC unit of Human Nutrition Research, Cambridge
  • University of Glasgow
  • Harakopio University, Athens, Greece
  • Aarhus University, Denmark

Teaching

I teach and examine on  undergraduate modules associated with BSc Degree programmes in Nutrition, Nutrition & Dietetics, Nutrition & Food Science and Biochemistry, and two MSc programmes.

  • BSc Degree programmes in Nutrition, Nutrition & Dietetics; Nutrition & Food Science, lecture topics include the Regulation & disorders of energy and lipid metabolism; Biomedical sciences; Macronutrients (dietary fats), Food Science
  • MSc Degree programmes in Nutritional Medicine (Lipids & essential fatty acids) and Human Nutrition. 

Departmental duties

Supervise MSc and PhD research programmes

Chairman for the Exam Board in Nutritional Medicine 2006 to date

Degree programme review panel member for BSc Undergraduate Framework for Lifelong Learning in Health and Social Care Practice, EIHMS, University of Surrey (2007)

Member of the Faculty's Research Advisory Board, FHMS, University of Surrey (2014-16)

Affiliations

  • Biochemical Society (1985-88)
  • British Hyperlipidaemia Association (1990-2002)
  • H.E.A.R.T. UK (2002 - to date)
  • The Nutrition Society (1994 - to date)
  • British Atherosclerosis Society (1997-2006)
  • The Royal Society of Medicine's Forum on Lipids in Clinical Medicine (1999-2006)
  • Scottish Heart and Arterial disease Risk Prevention Group (1999-2003)
  • Registered Nutritionist (RNutr 1999-to date)
  • Member of the College of Medicine's working group on nutrition

Additional Information

Current Editorial Board membership:

  • European Journal of Nutrition 
  • British Nutrition Foundation's Nutrition Bulletin

Committees:

  • British Hyperlipidaemia Association (BHA) Committee member (1999-2002)
  • Chairman for ILSI Europe's Functional Foods Task Force meetings in Lisbon, Portugal (2003) and Bordeaux, France (2004)
  • Deputy Director of Supra-regional Assay Service (SAS) in Cardiovascular Risk Assessment for the NHS Trust University of Surrey & RSCH (2003 - 2012)
  • Nutrition Society's Scientific Committee

News

Media Contacts

Contact the press team

Email:

mediarelations@surrey.ac.uk

Phone: +44 (0)1483 684380 / 688914 / 684378
Out-of-hours: +44 (0)7773 479911
Senate House, University of Surrey
Guildford, Surrey GU2 7XH

Research

Research interests

Research projects

Indicators of esteem

  • I am Research Section Leader in Metabolic Medicine, Food and Macronutrients within the Department of Nutritional Sciences at the University of Surrey, Theme Leader in Whole Body Metabolism and member of the Scientific Committee for the Nutrition Society, and an Editorial Board Member for the European Journal of Nutrition.  

My teaching

My publications

Publications

ORIGINAL PAPERS: 

Umpleby M, Shojaee-Moradie F, Fielding B, Li X, Marino A, Alsini N, Isherwood C, Jackson N, Ahmad A, Stolinski M, Lovegrove JA, Johnsen S, Jeewaka R Mendis AS, Wright J, Wilinska ME, Hovorka R, Bell JD, Thomas EL, Frost GS, Griffin BA (2017). Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets. Clinical Science 131, 2561-2573,

Cold F, Kristian HW, Pastor-Barriuso R, Rayman MP, Guallar E, Nybo M, Griffin BA, Stranges S, Cold S (2015). Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population. British Journal of Nutrition 114, 1807-1818.

Johns I, Goff L, Bluck LJ, Griffin BA, Jebb SA, Lovegrove JA, Sanders TA, Frost G, Dornhorst A (2014) Plasma free fatty acids do not provide the link between obesity and insulin resistance or β-cell dysfunction: results of the ‘RISCK’ study. Diabetes Medicine 31,1310-1315.

Harman NL, Griffin BA, Davies IG (2013) Separation of the principal HDL subclasses by iodixanol ultracentrifugation. Journal of Lipid Research 54, 2273-2281.

Meyer BJ, Stewart FM, Brown EA, Cooney J, Nilsson S, Olivecrona G, Ramsay JE, Griffin BA, Caslake MJ, Freeman DJ (2013). Maternal obesity is associated with the formation of small dense LDL and hypo-adiponectinaemia in the third trimester. Journal of Clinical Endocrinology & Metabolism 98, 643-652.

Goff LM, Griffin BA, Lovegrove JA, Sanders TA, Jebb SA, Bluck LJ, Frost GS (2013). Ethnic differences in beta-cell function, dietary intake and expression of the metabolic syndrome among UK adults of South Asian, black African-Caribbean and white-European origin. Diabetes Vascular Disease Research 10, 315-323.

Fallaize R, Wilson L, Gray J, Morgan LM, Griffin BA (2012). Variation in the effects of three different breakfast meals on subjective satiety and subsequent intake of energy at lunch and evening meal. European Journal of Nutrition 52,1353-1359. 

Fava F, Gitau R, Griffin BA, Tuohy KM, Gibson GR, Lovegrove JA (2012). Impact of the amount and quality of dietary fat and carbohydrate on the faecal microbiome and short-chain fatty acid excretion in a population “at-risk” of the metabolic syndrome. International Journal of Obesity 37, 216-223.

Walker CG, Loos RJF, Mander AP, Jebb SA, Frost GS, Griffin BA, Lovegrove JA, Sanders TAB and Bluck LJ (2012). Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat. Genes & Nutrition 7, 529-536.

 AlSaleh A, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TAB and O’Dell SD on behalf of the RISCK Study investigators. (2012). PPARγ2 gene Pro12Ala and PPARα gene Leu162Val SNPs interact with dietary intake of fat in determination of plasma lipid concentrations. Journal of Nutrigenetics & Nutrigenomics 4, 354-366. 

AlSaleh A, O’Dell SD,  Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TAB on behalf of the RISCK Study investigators (2011). Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk. Journal of Lipid Research 52, 2298-303.

Rayman MP, Stranges S, Griffin BA, Pastor-Barriuso R, Guallar E (2011). Effect of supplementation with high-selenium yeast on plasma lipids: a randomized, controlled trial. Annals of Internal Medicine 154, 656- 665.

Walker CG, Goff L, Bluck LJ, Griffin BA, Jebb SA, Lovegrove JA, Sanders TA, Frost GS; on behalf of the RISCK Study Group (2011). Variation in the FFAR1 Gene Modifies BMI, Body Composition and Beta-Cell Function in Overweight Subjects: An Exploratory Analysis. PLoS One. 6: e19146.

Alsaleh A, O'Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TA; on behalf of the RISCK Study Group (2011). Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome. American Journal of Clinical Nutrition 94, 262-269.  

Walker CG, Loos RJ, Olson AD, Frost GS, Griffin BA, Lovegrove JA, Sanders TA, Jebb SA (2011). Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids. Atherosclerosis 215, 421-427.  

Toft-Petersen AP, Tilsted HH, Aaroe J, Rasmussen K, Christensen T, Griffin BA, Aardestrup, Andreasen A & Schmidt EB (2011). Small dense LDL particles - a predictor of coronary artery disease evaluated by invasive and CT-based techniques. Lipids in Health and Disease 10, 21.  

Jebb SA, Lovegrove JA, Griffin BA, Frost GS, Moore CS, Chatfield MD, Bluck LJ, Williams CM, Sanders TAB (2010). Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) Trial. American Journal of Clinical Nutrition 92, 748-758.

Isherwood C, Wong M, Jones WS, Davies IG, Griffin BA (2010). Lack of effect of cold water prawns on plasma cholesterol and lipoproteins in normo-lipidaemic men. Cellular and Molecular Biology 56, 52-58.

Hampton SM, Isherwood C, Kirkpatrick VJ, Lynne-Smith AC, Griffin BA (2010).The influence of alcohol consumed with a meal on endothelial function in healthy individuals. Journal of Human Nutrition & Dietetics 23, 120-125.

Moore C, Gitau R, Goff L, Lewis FJ, Griffin MD, Chatfield MD, Jebb SA, Frost GS, Sanders TAB, Griffin BA, Lovegrove JA (2009) Successful manipulation of the quality and quanity of fat and carbohydrate consumed by free-living individuals using a food exchange model. The Journal of Nutrition 139, 1534-1540.

Rasmussen JG, Eschen RB, Aardestrup IV, Dethlefsen C, Griffin BA, Schmidt EB (2009). Flow mediated vasodilation: variation and inter-relationships with plasma lipids and lipoproteins. Scandinavian Journal of Clinical laboratory Investigation 69, 156-160.

Harman NL, Leeds AR & Griffin BA (2008). Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss. European Journal of Nutrition 47, 287-293

Lloyd DAJ, Paynton  SE, Bassett P, Mateos AR, Lovegrove JA, Gabe SM & Griffin BA (2008). Assessment of long chain n-3 polyunsaturated fatty acid status and clinical outcome in adults receiving home parenteral nutrition. Clinical Nutrition 27, 822-831

Morgan LM, Griffin BA, Millward DJ, DeLooy A, Fox KR, Baic S, Bonham MP, Wallace JMW, MacDonald I, Taylor MA & Truby H (2008). Comparison of the effects of four commercially available weight loss programmes on lipid-based cardiovascular risk factors. Public Health Nutrition 23, 1-9.

Paschos GK, Zampelas A, Panagiotakos DB, Katsiougiannis S, Griffin BA, Votteas V & Skopuli F (2007). Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men. European Journal of Nutrition. 46, 315-320.

Khodadadi I, Griffin B, Thumser A (2007). Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes. Archives of Iranian Medicine 11, 42-49.

Griffin MD, Sanders TAB, Davies IG, Morgan L, Millward DJ, Lewis F, Slaughter S, Cooper J & Griffin BA (2006). The effects of altering the ratio of dietary n-6/n-3 fatty acids on insulin sensitivity, lipoprotein size and postprandial lipemia in men and women aged 45 to 75 years, The OPTILIP study. American Journal of Clinical Nutrition 84, 1290-1298.

Sanders TAB, Lewis F, Slaughter S, Griffin BA, Griffin MD, Davies IG, Millward DJ, Cooper JA & Miller G. (2006). Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of α-linolenic acid, EPA and DHA, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70. The OPTILIP study. American Journal of Clinical Nutrition 84, 513-522.

Sanders TAB, Gleason K, Griffin BA & Miller GJ (2006) Influence of an algal triacylglycerol containing docosahexaenoic acid (22:6 n-3) and docosapentaenoic acid (22: 5 n-6) on cardiovascular risk factors in healthy men and women. British Journal of Nutrition. 95, 525-531.

Wilkinson P, Leach C, Ah-Sing E, Hussein N, Miller GJ, Millward DJ & Griffin BA (2005). Influence of a-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis 181, 115-124.

Panagiotakos DB, Pitsavos C, Zampelas A, Chrysohoou C, Griffin BA, Stefanadis C & Toutouzas P. (2005). Fish consumption and the risk of developing acute coronary syndromes: the CARDIO2000 study. International Journal of Cardiology 102, 403-409.

Paschos GK, Yiannakouris N, Rallidis LS, Davies I, Griffin BA, Panagiotakos DB, Skopouli FN, Votteas V, & Zampelas A. (2005) Apolipoprotein E-genotype in dyslipidaemic patients and response of blood lipids and inflammatory marker to a-linolenic acid. Angiology 56, 49-60.

Hussein N, Ah-Sing E, Wilkinson P, Leach C, Griffin BA & Millward DJ (2005). Relative rates of long chain conversion of [13C] linoleic and a-linolenic acids in response to their high and low dietary intakes in men with an atherogenic lipoprotein phenotype. Journal of Lipid Research 46, 269-280.

Davies IG, Graham JM & Griffin BA (2003). Rapid separation of LDL subclasses by iodixanol gradient ultracentrifugation. Clinical Chemistry 49, 1865-1872.

Khan S, Minihane AM, Talmud PJ, Wright JW, Murphy MC, Williams CM & Griffin BA (2002). Dietary long chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype. Journal of Lipid Research 43, 979-985.

Leigh-firbank EC, Minihane A-M, Leake DS, Wright JW, Murphy MC, Griffin BA & Williams CM (2002). Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses.  British Journal of Nutrition 87, 435-445.

Minihane AM, Khan S, Leigh Firbank E, Talmund PJ, Wright J, Murphy MC, Griffin BA &  Williams CM (2000). Apo E polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype (ALP) Arteriosclerosis, Thrombosis & Vascular Biology 20, 1990-1997.

Griffin BA, Furlonger N & Iversen SA (2000). Plasma apolipoprotein B to low-density lipoprotein cholesterol ratio as a marker of small, dense low-density lipoprotein. Annals of Clinical Biochemistry 37, 537-539.

Minihane AM, Khan S, Williams DL, Wright JW, Murphy MC, Griffin BA & Williams CM (2000). In subjects with an atherogenic lipoprotein phenotype (ALP), central adiposity is associated with an attenuated post-prandial triglyceride response International Journal of Obesity 24, 1097-1106.

Griffin BA, Minihane AM, Furlonger N, Chapman C, Murphy M, Williams D, Wright JW, Williams CM. (1999). Inter-relationships between small, dense LDL, plasma triglyceride and LDL apoprotein B in an atherogenic lipoprotein phenotype (ALP) in free-living subjects. Clinical Science 97, 269-276.

Nigdikar SV, Williams NR, Griffin BA & Howard AN. (1998). Consumption of red wine polyphenols reduces the susceptibility of low-density lipoproteins to oxidation in volunteers. American Journal of Clinical Nutrition 68, 258-265.

Freeman DJ, Caslake MJ, Griffin BA, Hinnie J, Tan CE, Watson TDG, Packard CJ & Shepherd J. (1998). The effect of smoking on post-heparin lipoprotein and hepatic lipase, cholesteryl ester transfer protein and lecithin:cholesteryl acyl transferase activities in human plasma. European Journal of Clinical Investigation 28, 584-591.

Gaw A, Packard CJ, Lindsay GM, Murray EF, Griffin BA, Caslake MJ, Colquhoun I, Wheatley DJ, Lorimer AR & Shepherd. (1996). Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism.  Arteriosclerosis, Thrombosis & Vascular Biology 16, 236-249.

Anber V, Griffin BA, McConnell M, Packard CJ & Shepherd J. (1996). Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans.  Atherosclerosis 124 (2), 261-271.

Tan KCB, Cooper MB, Ling KL, Griffin BA, Freeman DJ, Packard CJ, Shepherd J, Hales N & Betteridge DJ. (1995). Fasting and postprandial determinants for the occurrence of small, dense LDL species in non-insulin dependent diabetic patients with and without hyper-triglyceridaemia: the involvement of insulin, insulin precursor species and insulin resistance. Atherosclerosis 113, 273-287.

Gaw A, Packard CJ, Lindsay GM, Griffin BA, Caslake MJ, Lorimer AR & Shepherd J. (1995). Overproduction of small, very low density lipoproteins (Sf 20-60) in moderate hyper- cholesterolaemia: relationships between apolipoprotein B kinetics and plasma lipoproteins. Journal of Lipid Research 36, 158-171.

Gaw A, Packard CJ, Caslake MJ, Griffin BA, Lindsay GM, Thomson J, Vallance BD, Wosornu D  & Shepherd J. (1994). Effects of ciprofibrate on LDL metabolism in man. Atherosclerosis 108, 137-148.

Watson TDG, Caslake MJ, Freeman D, Griffin BA, Hinnie C, Packard CJ & Shepherd J. (1994). Determinants of LDL subfraction distribution and concentrations in normolipidaemic subjects. Arteriosclerosis & Thrombosis 14, 902-910.

Griffin BA, Freeman DJ, Tait GW, Thomson J, Caslake MJ, Packard CJ & Shepherd J. (1994). Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions. Relative contribution of small, dense LDL to coronary heart disease risk.  Atherosclerosis 106, 241-253.

Freeman DJ, Griffin BA, Holmes AP, Lindsay GM, Gaffney D, Packard CJ & Shepherd J. (1994).  Regulation of plasma HDL cholesterol and subfraction distribution by genetic and environmental factors.  Associations between the Taq I

B restriction length polymorphism in the CETP gene and smoking and obesity.  Arteriosclerosis & Thrombosis 14, 336-344.

Freeman DJ, Griffin BA, Murray E, Lindsay GM, Gaffney D, Packard CJ & Shepherd J. (1993).  Smoking and plasma lipoproteins: effects on cholesteryl ester transfer protein activity, low density lipoprotein cholesterol levels and high density lipoprotein subfraction distribution. European Journal of Clinical Investigation 23, 630-640.

Griffin BA, Farish E, Walsh D, Barnes J, Caslake MJ, Shepherd J & Hart D. (1993). Response of low density lipoprotein subfractions to oestrogen replacement therapy following surgical menopause. Clinical Endocrinology 39, 463-468.

Caslake MJ, Packard CJ, Gaw A, Murray EF, Griffin BA & Shepherd J. (1993). Fenofibrate and low density lipoprotein metabolic heterogeneity in hypercholesterolaemia. Arteriosclerosis & Thrombosis 13, 702-711.

Gaw A, Packard CJ, Murray EF, Linsay GM, Griffin BA, Caslake MJ, Vallance BD, Lorimer AR & Shepherd J. (1993).  Effects of simvastatin on apolipoprotein metabolism and LDL subfraction distribution.  Arteriosclerosis & Thrombosis 13, 170-189.

Wilson HM, Griffin BA, Watt C & Skinner ER. (1992). The isolation and characterisation of high density lipoprotein subfractions containing apolipoprotein E from human plasma. Biochemical Journal 284, 477-481.

Griffin BA, Caslake MJ, Gaw A, Sinnott M, Yip B, Packard CJ & Shepherd J. (1992). Effects of cholestyramine and acipimox on subfractions of plasma LDL.  Studies in normal and hypercholesterolaemic subjects. European Journal of Clinical Investigation 22, 383-390.

Wojciechowski AP, Farrall PC, Wilson TME, Bayliss JD, Farren B, Griffin BA, Caslake MJ, Packard CJ, Shepherd J, Thakker R & Scott J. (1991). Familial combined hyper-lipoproteinaemia is linked to the apoprotein AI-CIII-AIV gene cluster on chromosome 11q23-q24. Nature 349, 161-164.

Griffin BA, Caslake MJ, Yip B, Tait GW, Packard CJ &  Shepherd J. (1990). Rapid isolation of low density lipoprotein (LDL) subfractions from plasma by density gradient ultra-centrifugation. Atherosclerosis 83, 59-67.

Gaw A, Griffin BA, Caslake MJ, Collins SM, Lorimer AR, Packard CJ & Shepherd J. (1990). Effects of acipimox on apolipoprotein B metabolism and LDL subfraction distribution in hypercholesterolaemic subjects. Journal of Drug Development 3, 107-109.

Griffin BA, Skinner ER & Maughan RJ. (1988). The acute effects of prolonged walking and dietary changes on plasma lipoproteins and high-density lipoprotein subfractions. Metabolism 37, 535-541.

Griffin BA, Skinner ER & Maughan RJ. (1988). Plasma high-density lipoprotein subfractions in subjects with different coronary risk indices as assessed by lipoprotein  concentrations. Atherosclerosis 70, 165-169.

 INVITED REVIEWS, EDITORIALS & COMMENTARIES

Griffin BA & Lovegrove JA (2018) Butter increases HDL functional capacity: is this compensation for its adverse effect on serum LDL cholesterol? Journal of Nutrition (In press)

Griffin BA (2017) Serum low-density lipoprotein as a dietary responsive biomarker of cardiovascular disease risk: Consensus or confusion? British Nutrition Foundation. Nutrition Bulletin 42, 266-273.

Turner L, Poole K, Faithfull S & Griffin BA (2017) Current and future strategies for the nutritional management of cardio-metabolic complications of androgen deprivation therapy for prostate cancer Nutrition Research Reviews 13, 1-13.

Griffin BA (2015) Saturated fat: guidelines to reduce coronary heart disease risk are still valid. The Pharmaceutical Journal 294 (7858), Online URI 20068191.

Griffin BA (2014) Non-pharmacological approaches for reducing serum low-density lipoprotein cholesterol. Current Opinions in Cardiology 29, 360-365.

Gray J & Griffin BA (2013) Eggs: Establishing the nutritional benefits. British Nutrition Foundation. Nutrition Bulletin 38, 438-449.

Griffin BA (2013) Lipid metabolism. In: Surgery 31, 267-272.

Lovegrove JA & Griffin BA (2013). The acute and long-term effects of dietary fatty acids on vascular function in health and disease. Current Opinions in Nutrition & Metabolic Care 16, 162-167.

Griffin BA (2012) Goldilocks and the three bonds: new evidence for the conditional benefits of dietary alpha-linolenic acid in treating cardiovascular risk in the metabolic syndrome British Journal of Nutrition 108, 579-580,

Griffin BA, Agewall S (2012) Can increased arterial stiffness in women relative to men be explained by their progressive loss of gluteofemoral fat? Atherosclerosis 224, 320-321.

Lovegrove JA, Griffin BA (2011). Can dietary modification reduce the cardiovascular complications of metabolic syndrome? 'All for one' or 'one for all'? Expert Reviews in Cardiovascular Therapy 9, 413-416.

Mikhailidis DP, Elisaf MS, Rizzo M, Berneis K, Griffin B et al. (2011). "European Panel on Low Density Lipoprotein (LDL) Subclasses": A Statement on the Pathophysiology, Atherogenicity and Clinical Significance of LDL Subclasses: Executive Summary.  Current Vascular Pharmacology 9, 531-532.

Mikhailidis DP, Elisaf MS, Rizzo M, Berneis K, Griffin B, et al. (2011). "European Panel on Low Density Lipoprotein (LDL) Subclasses": A Statement on the Pathophysiology, Atherogenicity and Clinical Significance of LDL Subclasses.  Current Vascular Pharmacology 9, 533-571.

Griffin BA. (2011). Dairy, dairy, quite contrary: further evidence to support a role for calcium in counteracting the cholesterol-raising effect of SFA in dairy foods.  British Journal of Nutrition 14, 1-2. 

Griffin BA (2009) The nutritional properties of eggs. Journal of the Institute of Food and Technology 23, 14-16.

Gray J & Griffin B (2009). Eggs and dietary cholesterol - dispelling the myth.  British Nutrition Foundation Nutrition Bulletin 34, 66-70.

Mason P, Porter SC, Berry SE, Stillman P, Steele C, Kirby A, Griffin BA &  Minihane AM (2009). Saturated fatty acid consumption: outlining the scale of the problem and assessing the solutions. British Nutrition Foundation Nutrition Bulletin 34, 74-84.

Ferns G,  Keti V & Griffin B (2008). Investigation and Management of Hyper- triglyceridaemia. Journal of Clinical Pathology 61:1174-1183.

Griffin BA (2008). Dietary cholesterol; not something for most people to worry about. The British Dietetic Association: Dietetics Today 44, 44-47.

Griffin BA (2008). How relevant is the ratio of dietary n-6 to n-3 polyunsaturated fatty acids to cardiovascular disease risk? Evidence from the OPTILIP Study. Current Opinion in Lipidology 19: 57-62.

Jebb SA, Frost G, Griffin BA, Lovegrove JA, Moore C, Sanders T & Williams CM (2007). The RISCK Study; testing the impact of the amount and type of dietary fat and carbohydrate on metabolic risk. British Nutrition Foundation Bulletin 32, 154-156.

Stanley JC, Elsom RL, Calder PC, Griffin BA, Harris WS, Jebb JA, Lovegrove JA, Moore CS, Riemersma RA &.Sanders TAB (2007). The effects of the dietary n-6: n-3 fatty acid ratio on cardiovascular health: UK Food Standards Agency Workshop Report. British Journal of Nutrition 98, 1305-1310.

Lee A & Griffin BA (2006). Dietary cholesterol, eggs and coronary heart disease in perspective. British Nutrition Foundation Bulletin 31, 21-27.

Sanderson P, Olthof M, Grimble RF, Calder PC, Griffin BA, de Roos NM, Belch JJF, Muller DPR, & Vita JA (2004). Dietary lipids and vascular function: UK Food Standards Agency workshop report. British Journal of Nutrition 91, 491-500.

Mensink RP, Aro A, Hond ED, German B, Griffin BA, Meer HU, Mutanen M, Pannemans & Stahl W (2003). PASSCLAIM1 – Diet-related cardiovascular disease. European Journal of Nutrition 42 (Suppl. 1), 1/7-1/27.

Sanderson P, Finnegan YE, Williams CM, Calder PC, Burdge GC, Wooton SA, Griffin BA, Millward DJ, Pegge NC & Bemelmans WJE (2002). UK Food Standards Agency a-linolenic acid workshop report.  British Journal of Nutrition 88, 573-579.

Griffin BA (2002) Omega-3 fatty acids in the treatment of diabetic dyslipidaemia.  The Nutrition Practioner 4 (1), 35-37.

Griffin BA (2001). The effects of n-3 PUFA on LDL subfractions. Lipids 36, S91-S97.

Griffin BA (2001). Nutrition and Therapeutics (Editorial) Current Opinion in Lipidology 12, 457-459. (6.194)

Griffin BA & Fielding B (2001). Post-prandial lipid handling. Current Opinion in Clinical Nutrition and Metabolic Care 4, 93-98.

Griffin BA (2000). Nutrition and Metabolism (Editorial) Current Opinion in Lipidology 11, 425-427.

Griffin BA (1999). Cholesterol-lowering effects of high protein soya milk. British Journal of Nutrition 82, 79-80.

Griffin BA (1999). Small, dense atherogenic LDL - a silent risk factor. Cardiovascular Disease / Lipids Dialogue 9, 5-7.

Griffin BA (1998). Nutrition and Therapeutics (Editorial) Current Opinion in Lipidology 9, 267-269.

Griffin BA (1998).  Small, dense low-density lipoprotein (LDL); A risk factor for coronary heart disease? Issues in Preventive Cardiology (edited by: Sniderman AD) 1, 10-14.

Griffin BA (1996). Nutrition and Therapeutics Current Opinion in Lipidology 7, U77-U88.

Griffin BA & Zampelas A. (1995). The influence of dietary fatty acids on the atherogenic lipoprotein phenotype. Nutrition Research Reviews (edited by: Gurr MI) 8,1-26.

Griffin BA (1995) Nutrition (Editorial). Current Opinions in Lipidology 6, U85-U89.

Griffin BA & Packard CJ (1994). Metabolism of VLDL and LDL subclasses. Current  Opinions in Lipidology 5, 200-206.

Griffin BA. (1993). Lipid Metabolism (Editorial) Current Opinions in Lipidology 4, II-9  II-10.

Shepherd J, Griffin BA, Caslake MJ, Gaw A & Packard CJ. (1991). The influence of fibrates on lipoprotein metabolism. Atherosclerosis Reviews 22, 163-169.

 

 TRANSACTIONS & CONFERENCE PROCEEDINGS

Griffin BA (2016) Eggs: good or bad?  Proceedings of the Nutrition Society 75, 259-264.

Griffin BA (2015) Relevance of liver fat to the impact of dietary extrinsic sugars on lipid metabolism. Proceedings of the Nutrition Society 74, 208-214.

Williams CM, Lovegrove JA, Griffin BA. (2013) Dietary patterns and cardiovascular disease. Proceedings of the Nutrition Society 72, 407-411. 

Mitchell HL, Gibbins JM, Griffin BA, Lovegrove JA, Stowell JD, Foot E (2012) Food and Health Forum meeting:nutritional approaches to cardiovascular health: workshop report. British Nutrition Foundation Nutrition Bulletin (Epub ahead of print)

Cassidy A & Griffin BA (1999). Oestrogens and lipid-mediated CHD risk. Proceedings of the Nutrition Society 58, 193-199.

Griffin BA (1999). Lipoprotein atherogenicity: an overview of current mechanisms.  Proceedings of the Nutrition Society 58, 163-169.

Griffin BA. (1997). Low-density lipoprotein subclasses: mechanisms of formation and modulation. Proceedings of the Nutrition Society 56, 1-10.

Gaw A, Griffin BA, Gaffney D, Caslake MJ, Packard CJ & Shepherd J. (1990). Genetic and environmental modulation of low density lipoprotein catabolism.  Biochemical Society Transactions 18, 1072-1074.

Packard CJ, Caslake MJ, Griffin BA, Gaw A, Shepherd J. (1990). Fenofibrate and lipoprotein metabolism.  Drugs in Focus. Summary Proceedings of the 3rd International Workshop on Lipid Metabolism, Dijon, France pp 9-10.

Griffin BA, Skinner ER & Maughan RJ. (1986). Changes in plasma LCAT activity     during aerobic exercise. Biochemical Society Transactions 14, 1094-1095.

 

 BOOK CHAPTERS

Griffin BA (2018) 30 Seconds of Nutrition - ‘Fats’, ‘Metabolism’, ‘Eggs’, ‘Dietary Fats & Cardiovascular Disease’ ‘Profile on Ancel Keys’  (Edited by Lovegrove JA) Published by Ivy Press (In press). 

Escolà-Gil JC, Julve J, Griffin BA, Freeman D, Blanco-Vaca F (2015) HDL and lifestyle interventions. Handbook of Experimental Pharmacology 224, 569-92.

Griffin BA (2011). Eggs, dietary cholesterol and disease: facts and folklore. In: Improving the safety and quality of eggs and egg products Vol. 2 Egg Safety and nutritional quality Eds: Immerseel FV, Nys Y and Bain M Published by Woodhead Publishing Ltd. ISBN 978-85709-072-0

Griffin BA (2008). Nutrition and metabolism of lipids. In: Introduction to Human Nutrition. 2nd Edition. Published by Blackwell Sciences Ltd

Whitehead K & Griffin BA (2003). Lifestyle management: Diet. In: Coronary heart disease  prevention: a handbook for the health care team. Second Edition (Edited by Lindsay GM & Gaw A) Churchill Livingstone, pp:107-137.

Griffin BA, Wright JW. (1998). Assessment of cholesterol status: identification of small, dense   LDL. In:  Methodological Surveys in Bio-analysis of Drugs 25, (edited by: Reid E, Hill HM & Wilson ID) Published by the Royal Society of Chemistry. pp: 258-262 ISBN: 0-85404-748-4.

Cunnane SC & Griffin BA (2002). Nutrition and metabolism of lipids. In: Introduction to Human Nutrition. Eds. Gibney MJ, Vorster HH & Kok FJ. pp: 81-115 Blackwell Sciences Ltd.

Graham JM, Griffin BA, Davies IG & Higgins JA. (2000). Fractionation of lipoprotein subclasses in self-generated gradients of iodixanol. Atherosclerosis: methods and protocols, In: Methods in Molecular Biology (edited by: Drew AF) Humana Press pp: 51-61.

Griffin BA (2001). Current evidence for effects of dietary cholesterol. In: Dietary cholesterol as a cardiac risk factor: myth or reality. (edited by: Leeds AR & Gray J).  Published by Smith-Gordon & Co Ltd, pp: 27-34.

Gilbert NG & Griffin BA. (1997). Lifestyle management: Diet. In: Coronary Heart Disease Prevention: A Handbook for the Healthcare Team. (edited by: Gaw A &  Lindsay  GM) Churchill & Livingstone 6, pp: 107-138. ISBN 0-443-05460-6.

Griffin BA. (1995). Low density lipoprotein heterogeneity. In: Bailliere’s Clinical Endocrinology & Metabolism (edited by: Betteridge DJ) 9 (4), 687-703.ISBN: 0-702-01982-8.