Claire Price

Claire Price


Postgraduate Research Student
BA (Hons) Mathematical Sciences, BSc (Hons) Physical Science, BSc (Hons) Natural Sciences (BioChem), MSc Science, MSc Medicinal Chemistry

About

My research project

My qualifications

2020
MSc Medicinal Chemistry
The Open University
2019
PG Diploma Mental Health Science
The Open University
2015
MSc Science
The Open University
2010
PG Certificate Social Sciences
The Open University
2015
BSc (Hons) Natural Sciences (BioChem)
The Open University
2012
BSc (Hons) Physical Science
The Open University
2007
BA (Hons) Mathematical Sciences
The Open University

Affiliations and memberships

Institute of Physics
Member
Royal Society of Biology
Associate Member
Institute of Mathematics and its Applications
Associate Member

Publications

Agnieszka Lemanska, Claire A. Price, Nathan Jeffreys, RACHEL CLAIRE BYFORD, Hajira Dambha-Miller, X Fan, William Hinton, Sophie Otter, Rebecca Rice, Ali Stunt, Martin B. Whyte, Sara Faithfull, Simon De Lusignan (2022)BMI and HbA1c are metabolic markers for pancreatic cancer: Matched case-control study using a UK primary care database, In: PloS one17(10)e0275369 Public Library of Science

Background Weight loss, hyperglycaemia and diabetes are known features of pancreatic cancer. We quantified the timing and the amount of changes in body mass index (BMI) and glycated haemoglobin (HbA1c), and their association with pancreatic cancer from five years before diagnosis. Methods A matched case-control study was undertaken within 590 primary care practices in England, United Kingdom. 8,777 patients diagnosed with pancreatic cancer (cases) between 1st January 2007 and 31st August 2020 were matched to 34,979 controls by age, gender and diabetes. Longitudinal trends in BMI and HbA1c were visualised. Odds ratios adjusted for demographic and lifestyle factors (aOR) and 95% confidence intervals (CI) were calculated with conditional logistic regression. Subgroup analyses were undertaken according to the diabetes status. Results Changes in BMI and HbA1c observed for cases on longitudinal plots started one and two years (respectively) before diagnosis. In the year before diagnosis, a 1 kg/m2 decrease in BMI between cases and controls was associated with aOR for pancreatic cancer of 1.05 (95% CI 1.05 to 1.06), and a 1 mmol/mol increase in HbA1c was associated with aOR of 1.06 (1.06 to 1.07). ORs remained statistically significant (p < 0.001) for 2 years before pancreatic cancer diagnosis for BMI and 3 years for HbA1c. Subgroup analysis revealed that the decrease in BMI was associated with a higher pancreatic cancer risk for people with diabetes than for people without (aORs 1.08, 1.06 to 1.09 versus 1.04, 1.03 to 1.05), but the increase in HbA1c was associated with a higher risk for people without diabetes than for people with diabetes (aORs 1.09, 1.07 to 1.11 versus 1.04, 1.03 to 1.04). Conclusions The statistically significant changes in weight and glycaemic control started three years before pancreatic cancer diagnosis but varied according to the diabetes status. The information from this study could be used to detect pancreatic cancer earlier than is currently achieved. However, regular BMI and HbA1c measurements are required to facilitate future research and implementation in clinical practice.

CLAIRE PRICE, ROSE-MARIE SATHERLEY, CHRISTINA J JONES, MARY JOHN, Mary John (2022)Development and Evaluation of an eLearning Training Module to Improve United Kingdom Secondary School Teachers’ Knowledge and Confidence in Supporting Young People Who Self-Harm, In: Frontiers in education (Lausanne)7889659 Frontiers Media S.A

Background Self-harm is a major public health concern with evidence suggesting that the rates are higher in the United Kingdom than anywhere else in Europe. Increasingly, policy highlights the role of school staff in supporting young people (YP) who are self-harming, yet research indicates that school staff often feel ill-equipped to provide support and address self-harm behaviors. Here, we assess the impact of a bespoke eLearning module for United Kingdom secondary school teachers on teacher’s actual and perceived knowledge of self-harm, and their self-reported confidence in supporting and talking to YP who self-harm. Methods Twenty-one secondary schools across the West Midlands and South East of England were invited to complete a 30-min web-based eLearning module on self-harm in schools. Participants completed pre-and post-intervention measures. Results One-hundred and seventy-three teachers completed the eLearning, and pre-and post-measures. The eLearning significantly enhanced participants’ perceived knowledge, actual knowledge, and confidence in talking to and supporting YP who self-harm. The majority of participants (90.7%) felt that eLearning was a good way to receive training. Conclusion The 30-min eLearning module was rated highly and may be an effective way to increase secondary school teachers’ knowledge of self-harm, and confidence in supporting and talking to YP who self-harm.