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Dr Jonathan Brown


Senior Teaching Fellow in Nutrition and Food Science
+44 (0)1483 686409
35 AY 03

Biography

Biography

Academic Training

1984-1987: B.Sc. (Hons) Microbiology, Faculty of Science, University of Reading

1987-1988: M.Sc. Human Nutrition and Metabolism, Faculty of Medicine, University of Aberdeen

1989-1990: Graduate Research Assistant, Department of Medicine, University of Dundee

1991-1995: Ph.D. Biochemistry, Faculty of Medicine, University of Edinburgh

1994-1995: Graduate Research Fellow, William Harvey Research Institute, St. Bartholomew's Medical College, London

1996-1998: Post-doctoral Research Fellow, United Medical and Dental School, Guy's Hospital, London

1998-1999: Senior Research Fellow, Department of Pharmacy and Pharmacology, University of Bath

1999-Present: Lecturer in Food Safety, Faculty of Health and Medical Sciences, University of Surrey

2007: Fellow of the Higher Education Academy

Ph.D. Students

6 successfully completed; 3 currently active in their studies; 2 commencing soon (as of July 2009)

M.Sc. Students

8 successfully completed; one currently active in their studies (as of July 2009)

Research Income

£0.5M

Research interests

Polyphenols in health and disease

Absorption and metabolism of (poly)phenols

The role phytoestrogens in breast cancer

The role of phytoestrogens in bone health

Protective effects of (poly)phenols against UVA irradiation in biological systems

(Poly)phenolic compound identification and quantitation in foods and beverages

Antioxidant and metal chelation properties of polyphenols

Glycaemic index and the role of polyphenols

Herbs, their constituents and properties as antioxidants/antioxidants/cellular protective agents

Research collaborations

Dr Don Clarke, Central Science Laboratory, York

Professor Gary Williamson, University of Leeds

Professor Mike Clifford, University of Surrey

Barbara Parry, WINS research team, Winchester and Eastleigh Healthcare NHS Trust

Dr Valeria Rizzo, University of Catania, Italy

Professor Samir Khoja, King Abdula-Aziz University, Saudi Arabia

Dr Sue Lanham-New, University of Surrey

Teaching

  • BMS 1013 Food Science - lectures on the rancidity process, phytonutrients
  • BMS 2015 Food Science - lectures on food colours (e.g. anthocyanins, carotenoids, chlorophylls, haem pigments) and fruit ripening and storage methods
  • BMS 2016 Food Analysis - use of infrared in food analysis
  • BMS 2017 Practical Food Analysis - six practicals concerned with the analysis of sugars, starches, lipids and caffeine in food stuffs
  • BMS 2018 Key Skills 2 - assessment and feedback on student presentations from Nutrition and Nutrition/Food Science students
  • BMS 3021 Food Safety - lectures on nitrites, nitrates and nitrosamines
  • BMS 3022 Food Chemistry (module coordinator) - lectures on nitrate/nitrite, sulphites, phenols and polyphenols (5 lectures), antioxidants in foods and supplements, antioxidant methods
  • BMS 3023 Food Quality Assurance - lectures on carbohydrate, fat and vitamin analysis in foods
  • BMS 3024 Food Technology (module coordinator) - lectures on heat processing methods and newer methods of food processing (e.g. high pressure and pulsed electric fields), drying, evaporation and calculations related to processes
  • M.Sc. Nutritional Medicine module on Antioxidants, Phytoprotectants and Disease - lectures on anthocyanins and lignans as well as project student supervision
  • M.Sc. Clinical Biochemistry and Molecular Biology (Project student supervision)

Departmental duties

Professional Training Year Tutor for Food Science and Nutrition students 2000-Present

Professional Training and Careers Committee 2008-Present

Division of Nutritional Sciences PG Mentor 2008-Present

Nutrition Working Party Chair 2006-2008

Member of the FHMS Festival and Seminar Committee 2004-2006

Organiser of the SBMS/FHMS Post-grad Poster Show 2004-2007

Member of the Postgraduate Liaison Committee 2004-2008

SBMS Disability Co-ordinator 2001

Member of the Board of Studies 2000-Present

Member of the UG Exam Boards 2000-Present

Affiliations

Nutrition Society (member)

Society for Chemistry and Industry (member)

Royal Society of Chemistry (Food Chemistry Group member)

Society for Free Radical Research (member since 1989)

My publications

Publications

Papers

  • Al-Mssallem, M., Frost G., Hampton S. and Brown J.E. (2010) A study of Hassawi rice (Oryza sativa L.) in terms of its carbohydrate hydrolysis in vitro and glycaemic and insulinaemic indices in vivo. (submitted to EJCN)
  • Rizzo, V., Clifford, M.N. and Brown, J.E. (2010) The effects of processing on polyphenol and phenolic acid content and antioxidant activity of semi-dried cherry tomatoes (Lycopersicon esculentum M.) (in preparation)
  • Jamil, D.M., Howell, N.K. and Brown, J.E. (2010) Protection of low density lipoprotein from copper-mediated oxidation by the volatile oils of Thymus Syriacus Boiss. var syriacus and Thymbra spicata L. and their primary constituents (in preparation)
  • Jamil, D.M., Brown, J.E., Driscoll, D. and Howell, N.K. (2010) Characterization of the volatile oil content and composition of Thymus Syriacus Boiss. var syriacus and Thymbra spicata L. by gas chromatography (GC) and GC-mass spectrometry (in preparation)
  • Stoupi, S., Williamson, G., Viton F., Barron D., King, L.J. Brown, J.E. and Clifford M.N. (2010) In vivo bioavailability, absorption, excretion and pharmacokinetics of [14C] procyanidin in male rats. Drug Metabolism and Disposition, 38(2), 287-291
  • Brown, J.E. and Kelly M.F. (2008) Influence of dietary cholesterol and stress on the metabolism of linoleic acid: Δ6-desaturase activity vs. product precursor ratios. International Journal of Food Safety, Nutrition and Public Health 1: 5-15
  • Gannon, R.H.T., Millward D.J., Brown J.E., MacDonald H.M., Lovell D.P., Frasetto L.A., Remer T. and Lanham-New S.A. (2008) Estimates of net acid excretion (NAEind) and net rate of endogenous non-carbonic acid production (NEAP) in the elderly UK population: analysis of the National Diet and Nutrition Survey (NDNS) of British adults aged 65 years and over. British Journal of Nutrition 100:615-623
  • Rahimuddin, S.A., Khoja, S.M., Zuhair, M.M., Howell N.K. and Brown, J.E. (2007) Inhibition of lipid peroxidation in UVA-treated skin fibroblasts by luteolin and its glucosides. European Journal of Lipid Science Technology 109 (7): 647-655
  • Brown, J.E. and Kelly M.F. (2007) Inhibition of lipid peroxidation by anthocyanins, anthocyanidins and phenolic degradation products. European Journal of Lipid Science Technology 109 (1):66-71
  • Cassidy A., Brown J.E., Hawdon, A., Faughnan M.S., King L.J., Millward J., Zimmer-Nechemias L., Wolfe B. and Setchell K.D.R. (2006) Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. Journal of Nutrition 136:45-51
  • Clifford, M.N. and Brown J.E. (2006) Dietary flavonoids and health - broadening the perspective in - Flavonoids: Chemistry, Biochemistry and Application, Edited by Andersen and Markham CRC Press. pp 320-370
  • Harmer J. and Brown J.E. (2005) Properties of cyanidin-3-glucoside and malvidin-3-glucoside in relation to their ability to prevent low density lipoprotein oxidation at physiological concentrations. Nutrition and Health Current Topics IV, Edited by T. Carr and K. Descheemaeker, Garant Publishers pp. 167-168
  • Brown J.E. (2005) A critical review of methods used to estimate linoleic acid Δ6-desaturation ex vivo and in vivo. European Journal of Lipid Science Technology 107 (2):119-134
  • Faughnan M.S., Hawdon A., Ah-Singh E., Brown J.E., Millward D.J. and Cassidy A. (2004) Urinary isoflavone kinetics: the effect of age, gender, food matrix and chemical composition. British Journal of Nutrition 91 (4): 567-574
  • Au A., and Brown J.E. (2002) The role of glycosylation on the antioxidant properties of polyphenols. Free Radical Biology and Medicine 33 (S1) S198
  • Tyrrell R.M., Pourzand C.A., Brown J.E., Hejmadi V., Kvam E., Ryter S. and Watkin R.D. (2000) Cellular studies with UVA radiation: A role for iron. Radiation Protection Dosimetry 91 (1-3): 37-39
  • Brown J.E., Lindsay, R.M. and Riemersma, R.A.(2000) Linoleic acid metabolism in the spontaneously diabetic rat. Δ6-desaturase activity vs. product precursor ratios. Lipids 35 (12) 1319-1323
  • Shafi, S., Welzel, D., Weidinger, G., Brown J.E. and Born G.V. (2000) Effect of reserpine treatment on low-density lipoproteins in arterial wall and internal organs of rats. Journal of Cardiovascular Pharmacology 35:686-92.
  • Collins, A.R., Brown, J.E., Bogdanov, M., Cadet, J., Cooke, M., Douki, T., Dunster, C., Eakins, J., Epe, B., Evans, M., Farmer, P., Gedik, C.M., Halliwell, B., Herbert, K., Hofer, T., Hutchinson, R., Jenner, A., Jones, G.D.D., Kasai, H., Kelly, F., Lloret, A., Loft, S., Lunec, J., McEwan, M., Moller, L., Olinki, R., Podmore, I., Poulsen, H., Ravanat, J-L., Rees, J.F., Reetz, F., Shertzer, B., Spiegelhalder, B., Turesky, R., Tyrrell, R., Vina, J., Vinicombe, D., Weimann, A., de Wergifosse, B. and Woods, S.G. (2000) Comparison of different methods of measuring 8-oxoguanine as a marker of oxidative DNA damage. Free Radical Research 32, 333-341.
  • Pourzand C., Watkin R.D., Brown, J.E. and Tyrrell, R.M. (1999) Ultraviolet A radiation induces immediate release of iron in human skin fibroblasts: The role of ferritin. Proceedings of the National Academy of Sciences, USA 96:6751-6756.
  • Brown, J.E. and Rice-Evans, C.A. (1998) Luteolin-rich artichoke extract protects low-density lipoprotein from oxidation in vitro. Free Radical Research 29:247-255.
  • Brown, J.E., Khodr, H., Hider, R.C. and Rice-Evans, C.A. (1998) Structural-dependence of flavonoid interactions with copper ions: Implications for their antioxidant properties. Biochemical Journal 330:1173-1178.
  • Riemersma, R.A., Perkins, D., Brown, A.J. and Brown, J.E. (1994) Linoleic acid and coronary artery disease. American Journal of Clinical Nutrition 59:949-950.
  • Brown, J.E. and Riemersma, R.A. (1994) Effect of dietary cholesterol on delta-6-desaturase. Scottish Medical Journal 39:61.
  • Scott, N.A., Jennings, P.E., Brown, J.E. and Belch, J.J.F. (1991) Gliclazide: a general free radical scavenger. European Journal of Pharmacology 208:175-177.
  • Brown, J.E. and Wahle, K.W.J. (1990) Effect of fish oil and vitamin E supplementation on lipid peroxidation and whole blood aggregation in man. Clinica Chimica Acta 193:147-156.
  • Wahle, K.W.J. and Brown, J.E. (1990) Plasma lipid peroxidation and platelet aggregation during high intakes of fish oil fatty acids. Fett Wissenschaft Technologie 92:326-330.
  • Brown, J.E. and Wahle, K.W.J. (1989) Fish oil supplements, lipid peroxidation and platelet aggregation in man. Biochemical Society Transactions 17:493.
  • Collins, M.D., Brown, J.E. and Jones, D. (1988) Brachybacterium faecium gen. nov. sp. nov., a Coryneform bacterium from poultry deep litter. International Journal of Systematic Bacteriology 38:45-48.
  • Abstracts (posters and oral presentations)

  • Wahle K.W.J. and Brown, J.E. (1989) Plasma lipid peroxidation and vitamin E supplementation during high intakes of fish oil. In: Vitamin E symposium, Bochum, West Germany.
  • Brown, J.E., Jennings, P.E., Bridges, A.B., Scott, N. and Belch, J.J.F. (1990) Atherosclerosis, diabetes and free radicals. In: Abstracts of the 635th Meeting of the Biochemical Society, Aberdeen, Scotland.
  • Jankowski, J., Bridges, A., Scott, N., Brown, J.E. and Belch J.J.F. (1990) Circulating free radicals and peptic ulcer disease. Gut 31 (10) A1183-A1183.
  • Brown, J.E. and Riemersma, R.A. (1992) Coronary heart disease and Δ6-desaturase: Methodological aspects of Δ6-desaturase measurement. Scottish Lipid Discussion Group Meeting, Glasgow, Scotland, UK.
  • Brown, J.E. and Riemersma, R.A. (1993) The effects of dietary cholesterol and isolation stress on Δ6-desaturase in the rat. Scottish Lipid Discussion Group Meeting, St. Andrews, Scotland, UK.
  • Brown, J.E. and Riemersma, R.A. (1993) Effect of dietary cholesterol on Δ6-desaturase. Scottish Society for Experimental Medicine, Edinburgh, Scotland, UK.
  • Brown, J.E., Lindsay, R.M. and Riemersma, R.A. (1993) Altered Δ6-desaturase activity and fatty acid composition in liver and plasma in the spontaneously diabetic BB rat. International Society for the Study of Fatty Acids and Lipids, Lugano, Switzerland.
  • Brown, J.E., Lindsay, R.M. Baird, J.D., Riemersma, R.A. (1996) Reduced Δ6-desaturation of linoleic acid in insulin treated BB diabetic rats. British Diabetic Association - Medical and Scientific Section Spring Meeting, Dublin, Ireland.
  • Brown, J.E. and Rice-Evans, C. (1996) Flavonoid structure and antioxidant activity. VIII Biennial Meeting of the International for Free Radical Research, Barcelona, Spain.
  • Paganga, G., Brown, J.E. and Rice-Evans, C. (1996) Simultaneous determination of the major families of polyphenolic compounds in vegetables by HPLC. VIII Biennial Meeting of the International for Free Radical Research, Barcelona, Spain.
  • Brown, J.E. (1997) Structure-antioxidant activity relationships of flavonoids. Mini-Symposium on Phytoprotectants. The Rank Prize Funds, Grasmere, England.
  • Brown, J.E., Khodr, H., Hider, R.C., Rice-Evans, C.A. (1998) Structural dependence of flavonoid interactions with Cu(II) ions: Implications for their antioxidant properties. World Congress of the Oxygen Club of California: Oxidants and Antioxidants in Biology, Santa Barbara, CA, USA.
  • Brown, J.E. and Rice-Evans, C.A. (1999) Artichoke extract protects LDL from oxidation. Meeting of the Society of Medicinal Plant Research, Amsterdam, The Netherlands.
  • Brown, J.E. and Rice-Evans C.A. (2000) Structural determinants of antioxidant activities in anthocyanidins. Meeting of the Society for Free Radical Research, Liverpool, England.
  • Tyrrell, R.M, Pourzand, C.A., Brown J.E., Hejmadi, V., Kvam E., Ryter, S. and Watkin R. (2000) Iron and heme release as key factors in the response of skin cells to UVA radiation. World Congress of the Oxygen Club of California: Oxidants and Antioxidants in Biology, Santa Barbara, CA, USA.
  • Brown, J.E. (2001) Flavonoids - A natural class of metal chelators relevant to health. London's Chemistry, London, England.
  • Au, A and Brown, J.E. (2002) The role of glycosylation on the antioxidant properties of polyphenols. XIth Meeting of the Society for Free Radical Research International, Paris, France
  • Harmer, J. and Brown, J.E. (2003) Properties of cyanidin-3-O-glucoside and malvidin 3-O-glucoside in relation to their ability to prevent LDL oxidation at physiological concentrations. 4th Nutrition and Health Conference, London, UK.
  • Harmer, J. and Brown J.E. (2004) The modulation of anthocyanin antioxidant activity by albumin. Summer Meeting of the Society for Free Radical Research Europe, Lodz, Poland.
  • Rahimuddin, S., Brown, J.E., Howell N.K. and Khoja, S.M. (2004) Effect of Luteolin and its glucosides on the prevention of UVA-induced oxidative damage in human skin fibroblasts. The Second Saudi Science Conference, Jeddah, Saudi Arabia.
  • Brown, J.E. (2004) The effect of physiologically relevant concentrations of dietary anthocyanins on their ability to prevent LDL oxidation in the presence and absence of serum albumin. Nutrition Society Annual Summer Meeting, Dublin, Ireland.
  • Rahimuddin, S., Brown, J.E., Howell N.K. and Khoja, S.M. (2004) Effect of Luteolin and its glucosides on the prevention of UVA-induced oxidative damage in human skin fibroblasts. SBMS Festival of Research, University of Surrey, Guildford, UK.
  • Parry B.M., Brown J.E., S.M. Horton, J.M. Stilwell, D.B. Clarke, J.M. Lawrence, M. Raats, L. Storey and R.M. Rainsbury. (2005) Investigation of the phytoestrogen intake of group of postmenopausal women previously treated for breast cancer. Food Standards Agency Meeting, Gatwick, UK.
  • Stoupi S., Clifford M.N., Kuhnert N., Brown J.E. and Williamson G. (2006) Gut flora metabolism of flavan-3-ols. SBMS Festival of Research, University of Surrey, Guildford, UK.
  • Parry B.M., Brown J.E., S.M. Horton, J.M. Stilwell, D.B. Clarke, J.M. Lawrence, M. Raats, L. Storey and R.M. Rainsbury. (2006) Investigation of the phytoestrogen intake of group of postmenopausal women previously treated for breast cancer. Food Standards Agency Meeting, Slaley Hall, Hexham, UK.
  • Brown, J.E., J.W. Tong, B.M. Parry, S.M. Horton, J.M. Stilwell, D.B. Clarke, J.M. Lawrence, M. Raats, L. Storey and R.M. Rainsbury. (2006) Creation of a new phytoestrogen database for the assessment of dietary intakes of isoflavones, coumestans and lignans in a group of postmenopausal women previously treated for breast cancer. Soy and Health Conference, Düsseldorf, Germany.
  • Parry B.M., Brown J.E., S.M. Horton, J.M. Stilwell, D.B. Clarke, J.M. Lawrence, M. Raats, L. Storey and R.M. Rainsbury. (2007) Investigation of the phytoestrogen intake of group of postmenopausal women previously treated for breast cancer. Food Standards Agency Meeting, Slaley Hall, Hexham, UK.
  • Brown J.E., K. Chana, C. Mahende. (2007) Differences in the absorption and excretion of soy milk isoflavones in Oriental and Caucasian men. Nutrition Society Annual Meeting, Coleraine, N. Ireland
  • Stoupi S., Clifford M.N., Williamson G and Brown J.E. (2007) Gut flora metabolism of (-)epicatechin. SBMS Festival of Research, University of Surrey, Guildford, UK.
  • Jamil D., Brown J.E., Driscoll D., Howell N. (2007) Gas chromatographic (GC) and GC-MS analysis of volatile oil components of Thymbra spicata L. and Thymus syriaca Boiss. var syriaca. SBMS Festival of Research, University of Surrey, Guildford, UK.
  • Parry B.M., Lawrence J.M., Storey L., Brown J.E., Clarke D.B., Raats M., Horton S.M., Stilwell J.M., and Rainsbury R.M. (2007) Food choice and phytoestrogen consumption in women previously treated for post-menopausal breast cancer. WCRF and AICR Second Expert Launch Conference, Washington DC, USA.
  • Brown J.E., K. Chana, C. Mahende. (2007) Absorption and excretion of soy milk isoflavones differs between Oriental and Caucasian men. University of Surrey Festival of Research, November 2007, Guildford, Surrey, UK
  • Stoupi, S., Clifford, M.N., Williamson, G. and Brown, J.E. (2007) A comparison of the biotransformation of procyanidin B2 and (-)epicatechin by human colonic bacteria. 3rd International Conference on Polyphenols and Health, Kyoto, Japan.
  • Parry B.M., Lawrence J.M., Storey L., Brown J.E., Clarke D.B., Raats M., Horton S.M., Stilwell J.M., and Rainsbury R.M. (2008) Food choice and phytoestrogen consumption in women previously treated for post-menopausal breast cancer. Breast Cancer Research 2008, The Royal Society, London, UK.
  • Jamil D., Brown J.E., Driscoll D. Howell N.K. (2008) Composition and antioxidant properties of thyme and thymbra. FHMS Festival of Research, University of Surrey, Guildford, UK.
  • Mssallem-Al M, Driscoll D., Frost G., and Brown J.E. (2008) Carbohydrate bioavailability in vitro and in vivo. FHMS Festival of Research, University of Surrey, Guildford. UK.
  • Stoupi, S., Williamson G., Drynan J.W., Brown J.E., and Clifford M.N. (2008) A comparison of the biotransformation of (-)-epicatechin and procyanidin B2 by human colonic bacteria. FHMS Festival of Research, University of Surrey, Guildford. UK.
  • Brown, J.E., Cropp, E., Rizzo, V. (2009) Carotenoid content and antioxidant activity of fourteen tomato ketchups available in the UK. FHMS Festival of Research, University of Surrey, Guildford. UK.
  • Al-Mssallem, M., Frost G., Hampton S. and Brown J.E. (2009) A study of Hassawi rice in terms of its carbohydrate hydrolysis in vitro and glycaemic and insulinaemic indices in vivo. FHMS Festival of Research, University of Surrey, Guildford. UK.
  • Al-Mssallem, M., Frost G. and Brown J.E. (2009) Compositional analysis of Hassawi rice (Oryza sativa L.) and its associated glycaemic and insulinaemic indices. Nutrition Society Annual Meeting, Guildford, Surrey, UK.
  • Brown, J.E., Cropp, E. and Rizzo, V. (2009) Carotenoid content and antioxidant activity of fourteen tomato ketchups available in the UK. Nutrition Society Annual Meeting, Guildford, Surrey, UK.
  • Jamil, D.M., Brown J.E., Driscoll, D. and Howell, NK. (2009) Characterization and antioxidant activity of the volatile oils of Thymus Syriacus Boiss. var syriacus and Thymbra spicata L. grown wild in Kurdistan-Iraq. Nutrition Society Annual Meeting, Guildford, Surrey, UK.