Dr Marika Kaakinen


Biography

Areas of specialism

Statistical genetics; Multi-omics data

University roles and responsibilities

  • Academic Integrity Officer
  • Ethics Committee member
  • Personal tutor
  • PTY tutor
  • Research supervisor

    Affiliations and memberships

    Frontiers in Genetics, section Human and Medical Genomics
    Associate Editor
    Genes journal
    Editorial board member

    Research

    Research interests

    Research collaborations

    Supervision

    Postgraduate research supervision

    Completed postgraduate research projects I have supervised

    My teaching

    Courses I teach on

    Undergraduate

    My publications

    Publications

    Alexessander Da Silva Couto Alves, N. Maneka G. De Silva, Ville Karhunen, Ulla Sovio, Shikta Das, H. Rob Taal, Nicole M. Warrington, Alexandra M. Lewin, Marika Kaakinen, Diana L. Cousminer, Elisabeth Thiering, Nicholas J. Timpson, Tom A. Bond, Estelle Lowry, Christopher D. Brown, Xavier Estivill, Virpi Lindi, Jonathan P. Bradfield, Frank Geller, Doug Speed, Lachlan J. M. Coin, Marie Loh, Sheila J. Barton, Lawrence J. Beilin, Hans Bisgaard, Klaus Bonnelykke, Rohia Alili, Ida J. Hatoum, Katharina Schramm, Rufus Cartwright, Marie-Aline Charles, Vincenzo Salerno, Karine Clement, Annique A.J Claringbould, BIOS Consortium, Cornelia M. van Duijin, Elena Moltchanova, Johan G. Eriksson, Cathy Elks, Bjarke Feenstra, Claudia Flexeder, Stephen Franks, Timothy M. Frayling, Rachel M. Freathy, Paul Elliot, Elisabeth Widen, Hakon Hakonarson, Andrew T. Hattersley, Alina Rodriguez, Marco Banterle, Joachim Heinrich, Barbara Heude, John W. Holloway, Albert Hofman, Elina Hypponen, Hazel Inskip, Lee M. Kaplan, Asa K. Hedman, Esa Laara, Holger Prokisch, Harald Grallert, Timo A. Lakka, Debbie A. Lawlor, Mads Melbye, Tarunveer S. Ahluwalia, Marcella Marinelli, Iona Y. Millwood, Lyle J. Palmer, Craig E. Pennell, John R. Perry, Susan M. Ring, Markku J. Savolainen, Fernando Rivadeneira, Marie Standl, Jordi Sunyer, Carla M.T Tiesler, Andre G. Uitterlinden, William Schierding, Justin M. O'Sullivan, Inga Prokopenko, Karl-Heinz Herzig, George Davey Smith, Paul O'Reilly, Janine F. Felix, Jessica L. Buxton, Alexandra L. F Blakemore, Ken K. Ong, Vincent W.V Jaddoe, Struan F.A Grant, Sylvain Sebert, Mark L. McCarthy, Marjo-Riitta Jarvelin (2019)GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI, In: Science Advances5(9) American Association for the Advancement of Science

    Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.

    Additional publications