Dr Rita Jabr
Lecturer in Cardiac Electrophysiology
Senior Research Fellow. Department of Cardiac Electrophysiology, National Heart and Lung Institute, Imperial College London, UK.
Senior Research Fellow. Cardiovascular Division, Department of Cardiology, The Rayne Institute, King's College London, UK.
Honorary Lecturer/Senior Research Fellow. Centre for Clinical Pharmacology and Toxicology, Department of Medicine, University College London, UK.
Assistant Professor. Department of Physiology, Faculty of Medicine, Kuwait University, Kuwait.
Postdoctoral Fellow. Department of Physiology and Cell Biology, School of Medicine, University of Nevada, USA.
Research Fellow (PhD student). Physiology Department, University of Manitoba, Canada.
Honorary posts:2013-present Director of Translational Research. Ashford and St Peters NHS Foundation Trust, UK.2013-present Honorary Assistant Professor, University of Pittsburgh, USA.2012-present Physiological Society representative for the University of Surrey2008-2010 Honorary Teaching Fellow, Department of Physiology, Royal Free and University College Medical School.2002-2008 Professional Development Spine Tutor/facilitator, Academic Centre for Medical Education, Medical Education, University College London.
Summary of my current research interestsResearch profile:My research concerns the characterisation of intracellular and intercellular signalling pathways, primarily in cardiac and smooth muscle, in relation to normal and pathological excitation-contraction coupling. In particular, I am interested in evaluating these signalling pathways to explain the fundamental processes regulating: excitation and conduction of electrical signals; generation of contractile force; regulation of cell growth. I have translated these fundamental studies to characterise the basic intracellular and intercellular changes that underlie pathological situations associated with the heart (e.g. arrhythmias, heart failure, hypertrophic muscle growth) and smooth muscle organs (e.g. pulmonary hypertension, atherosclerosis, overactive bladder). My work involves investigative laboratory experimentation with well-characterised animal models of normal function and human pathological conditions, as well as collaboration with clinicians to extend this work to the use of tissues obtained from patients with clinically characterised pathological conditions.
My particular expertise, for which I have international recognition, is concerned with the role of intracellular phosphatises and kinases to regulate the activity of several key stages concerned with electrical signal transmission, contractile regulation and tissue growth and development. I have pioneered studies that have characterised the role of the intracellular Ca2+-dependent phosphatase, calcineurin, in these fundamental physiological pathways
Current Research InterestsThese explore the role of serine-threonine protein phosphatase 3, calcineurin, its intracellular targets and the contribution it has to the normal and pathological function of cardiac and visceral smooth muscle organs. In particular I am investigating:
1. The regulation of gap junction and ion channel function in myocardium, including tissue from patients with atrial fibrillation and animal models of left ventricular hypertrophy. This is motivated to understand the cell and tissue basis of cardiac arrhythmias.
2. Regulation by intracellular phosphatases of myocardial and visceral organ hypertrophy and characterisation of consequent changes to the key intracellular regulatory pathways associated with pathologies such as cardiac arrhythmias, myocardial failure, benign lower urinary tract disorders and initiation of visceral pain.
3. Protocols to devise and validating more accurate methods to measure the electrical properties of cells (e.g. with impedance and dielectrophoresis methodologies) to generate more reliable experimental models to evaluate the action of the above phosphatises and kinases.
4. Investigation of the role of the above intracellular signalling pathways to control chronobiological rhythms and their association with atrial fibrillation.
Technical Skills:Electrophysiology:Patch-clamp technique; intracellular microelectrode or extracellular monophasic action potential recording simultaneously with isometric muscle contractions; tissue impedance measurement; multi-electrode array system; dielectrophoresis.
Muscle Contraction:Recording isometric muscle contractions in cardiac and smooth muscle preparations; measurement of isolated cardiomyocyte mechanics.
Imaging Techniques:Immunofluorescence with laser scanning confocal microscopy; real-time intracellular Ca2+ imaging by epifluorescence microscopy, cell shortening by video-scanning methods.
Biochemistry:Protein phosphatase activity assays; subcellular tissue fractionation; SDS-PAGE and western blotting; PCR; mouse genotyping; Baculovirus protein expression system.
Cell Preparation:Single cardiac and vascular smooth muscle cells isolation techniques.
Tissue Culture:Primary and cell-line tissue culture; proliferation assay.
External research collaborations:National collaboration
•Prof CH Fry on regulation of the biophysical properties of cardiac and smooth muscle, including novel methods to measure gap junction properties in multicellular tissues, as well as control of epithelial transmitter release and downstream modulation of smooth muscle function.
•Dr Michaele Mahmoudi.on biomarkers in cardiac pathologies.
• Prof M Hughes and Dr F Labeed, FEPS, Biochemical engineering division; Faculty of Engineering and Physical Sciences, University of Surrey on the development of techniques to measure the biophysical properties of muscle cells.
• Cardiologists/cardiac surgeons at St George's Hospital, Ashford & St Peters and The Royal Surrey County Hospital NHS trusts to characterise abnormal functional properties of myocardium with well-characterised cardiac pathologies.1. I am the lead on the investigative component on the HASTE foundation funded grant in collaboration with Royal Surrey.2. Honorary director of translational research, Ashford and St Peters NHS Trust.
• Prof R La Ragione, School of Veterinary Medicine, University of Surrey. Prof La Ragione is a collaborator in my currently funded BHF grant.
• Dr Richard Heads at King's College London concerning the role of calcineurin in fibroblast dysfunction during cardiac inflammation.
•I have recently expanded the atrial fibrillation project (HASTE) and initiated collaborations with Prof David Paterson, Oxford University and Dr Andrew James, University of Bristol.
•Dr Van Der Veen (University of Surrey) Dr Sam Boatang (University of Reading) on role of clock genes in vcardiac arrhythmias.
International collaboration• Dr A Aiello, Centre for Cardiovascular Sciences, University of La Plata, Buenos Aires, Argentina. Dr Aiello's expertise is in Na loading transporters in the heart. This was facilitated by:1. Santander Staff Award (£2K) to visit and conduct research at University of La Plata, Argentina (2012 and 2014)2. Santander PhD students award (£5K) for a PhD student from La Plata University (2012)Awarded a Santander scholarship certificate for an outstanding performance and dedication in the field of study -FHMS-(March 2013).
• Dr Perrino, Department of Physiology and Cell Biology, University of Nevada Reno, USA. Dr Perrino is an experienced biochemist in manufacturing constitutively active calcineurin isoforms.
• Prof P Lampe, Fred Hutchinson, Cancer Research Centre, Seattle, USA. Prof Lampe is an expert in gap junctions biochemistry and phosphorylation.
Research Funding:Research Grants:Current grants2013-2015 (£128,000; PI: R Jabr, Co-I: CH Fry). Title: Investigation of the role of calcineurin in persistent electrophysiological myocardial changes following regression from left ventricular hypertrophy. Funded by British Heart Foundation
2013-2014 (£8,000; Co-PI: R Jabr). Title: MicroRNAs as potential biomarkers in coronary artery calcification. Biomedical & Health Research Pump-Priming Funds grant, University of Surrey, 2011-2015 (£638,000) HASTE Foundation. Title: Improving detection and characterising the fundamental basis of atrial fibrillation. I am the Lead on the investigative research component (Dr E Leatham is lead on the clinical component and Prof CH Fry the manager of both components)
Past grants2008-2010 (£147,280; PI: R Jabr, Co-I: CH Fry). Title: The role of calcineurin in regulating action potential propagation in normal and hypertrophied myocardium through connexin43 dephosphorylation. Funded by British Heart Foundation
2009-2012 (€300,000; PI: CH Fry; Co-I, R Jabr). Title: Combatting Incontinence : InComb-EU Framework 7.
1999-2000 (£80,000- PI R Jabr). Title: Contractile and electrophysiological properties of cardiac ventricular myocytes in spontaneously hypertensive rats before and during development of hypertension, 1999. Funded by Kuwait University.
Research supervision and management
Manager and supervisor of post-doctoral fellows, post/undergraduate students:•Postdoctoral fellows:2010-present Line manager for three postdoctoral fellows. Two financed from HASTE project and one from currently funded BHF project grant.2009-2010 Line managed postdoctoral fellow, funded by BHF project grant.2000-2008 Trained/co-supervised several postdoctoral fellows at UCL/King's College London and Imperial College London (NHLI).
•Postgraduate students:2009-present 1. Supervisor for 3 PhD students at University of Surrey. One PhD student passed, September, 2013.2. Co-supervisor for one PhD student in Biochemical Engineering division; Faculty of Engineering & Physical Sciences, and one PhD student in Dept of Biochemistry & Physiology, University of Surrey.2009-2013 Supervised three MSc Toxicology students.2009-2012. Supervised MSc Erasmus students (University of Milan).2009-2011 Mentor for PhD/MD/MSc students in Clinical Medicine Division at The Postgraduate Medical School, University of Surrey.2009-present Personal tutor for MSc Toxicology students.2009-present Supported/mentored several PhD students in the faculty at research, scientific or personal levels.2007-2008 Co-supervised MD/Ph.D. student at NHLI, Imperial College London.
Invited research lectures:2012 Centre for Cardiovascular investigation; Faculty of Medicine; University of La Plata.Title: The differential role of calcineurin isoforms in the cardiovascular system.
2011 Physiological Society Meeting, Oxford, July, 2011Title: Inter-relationship between conduction velocity, intracellular Ca2+ and gap junction resistance in ventricular myocardium
2011 University of Surrey, FHMS, Research day, 'Hot topics in cardiovascular research'.Title: Cellular mechanisms for cardiac arrhythmogenesis.
2010 Pfizer, sandwich, UK.Title: Role of calcineurin in overactive bladder.
2010 The FP7 mid-term meeting, UK.Title: Use of the dielectrophoresis technique for selective cell sorting of bladder urothelial cells.
2009 The European Society of Cardiology, Munich, Germany.Title: Calcineurin nuclear import.
2009 The Marie Curie- Nuclear Receptors Biology Meeting, UK.Title: Role of nuclear calcineurin in the heart.
2008 UK Gap Junction meeting, University of Surrey, UK.Title: Calcineurin slows conduction velocity during rapid pacing in guinea pig papillary muscle.
Teaching• Module organiser for BMS1032 Physiology 1 module (15 credits; Level 4)• Module organiser for BMS2038 Physiology 2 module (15 credits; Level 5)• Lectures:1.Undergrad Physiology teaching:Cardiovascular system; Renal physiology; body fluids and electrolytes; acid-base balance; female reproductive system and pregnancy; Physiology practicals.
2. Receptors and intracellular signalling pathways for undergraduate/ postgraduate modules including:L5 BMS2035MSc ToxicologyMSc Nutrition MedicineMSc Health and Clinical Sciences
3. Cardiovascular toxicity for MSc Toxicology.
•Supervision of BSc, MSc and PhD research projects
•Physiological Society UK•British Society for Cardiovascular Research•International Society for Heart Research•Royal Society of Medicine•AES (Qatar Foundation's premier intellectual exchange network and Arab science revival initiative.
Other posts• Honorary Director of Translational Research. Ashford and St Peters NHS Trust, UK.• Honorary Assistant Professor, University of Pittsburgh, USA.• Representative of the Physiological Society at University of Surrey.
1 Gray RP, Dhillon P, Jacques A, Walker JM, Jabr RI, Marston S, Peters NS, McKenna W, Fry CH (2014). Electromechanical properties of isolated myocardium from patients with hypertrophic obstructive cardiomyopathy. Circulation (Arrhythmias and Electrophysiology) - under revision.
2 Fry CH, Gray RP, Dhillon PS, Jabr RI, Patel PM, Peters NS (2014). Relationship between intracellular conductance, action potential conduction, gap junction topology and tissue architecture in guinea-pig left ventricular hypertrophy. Circulation (Arrhythmias and Electrophysiology) - under revision
3 Dhillon PS, Chowdhury RA, Patel PM, Jabr R, Momin AU, Vecht J, Gray R, Shipolini A, Fry CH, Peters NS. (2014) Relationship between connexin expression and gap-junction resistivity in human atrial myocardium. Circulation (Arrhythmias and Electrophysiology):1: 7: 321-329.
4 Fry CH and Jabr RI. (2014) T-type Ca2+ channels and the urinary and male genital tracts. Pflügers Archives - European Journal of Physiology: 466: 781-789.
5 Paul MA, Mesquita RF, Jabr R, Marber MS, Brain SD, Mahadeo VB, Heads RJ (2014). Protein kinase-C epsilon regulates cardiac fibroblast phenotype by transcriptional co-operation with calcineurin via TLR4 and COX-2. Molecular and Cellular Biology; 34: 574-594
6 Dhillon PD, Gray R, Kojodjojo P, Jabr R, Chowdhury R, Fry CH, Peters NS (2013). The relationship between gap junction conductance and conduction velocity in mammalian myocardium. Circulation Electrophysiology and Arrhythmias: 6: 1208-1214.
7 Fahmi A, Smart N, Punn A, Jabr R, Marber M, Heads R (2013). p42/p44-MAPK and PI3K are Sufficient for IL-6 Family Cytokines/gp130 to Signal to Hypertrophy and Survival in Cardiomyocytes in the Absence of JAK/STAT Activation. Cell Signalling: 25: 898-909.
8 Fry CH, Salvage SC, Manazza A, Dupont E, Labeed FH, Hughes MP, Jabr RI (2012). Cytoplasm resistivity of mammalian atrial myocardium determined by dielectrophoresis and impedance methods. Biophysical Journal: 103: 2287-2294.
9 Fry CH, Young JS, Jabr RI, McCarthy C, Ikeda Y, Kanai AJ (2012). Modulation of spontaneous activity in the overactive bladder - the role of P2Y agonists. American Journal of Physiology, Renal Physiology: 302: F1447-1454.
10 Wyndaele JJ, Gammie A, Bruschini H, De Wachter S, Fry CH, Jabr RI, Kirschner-Hermanns R, Madersbacher H (2011). Bladder compliance what does it represent: can we measure it, and is it clinically relevant? Neurourology and Urodynamics: 30: 714-722.
11 Fry CH, Sadananda P, Wood DN, Thiruchelvam N, Jabr RI, Clayton R (2011). Modeling the urinary tract - computational, physical, and biological methods. Neurourology and Urodynamics: 30: 692-699.
12 Fry CH, Jabr RI. (2010) The action potential and nervous conduction. Surgery Feb.
13 Cook AR, Bardswell SC, Pretheshan S, Dighe K, Kanaganayagam GS, Jabr RI, Merkle S, Marber MS, Engelhardt S, Avkiran M (2009). Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress? Journal of Molecular and Cellular Cardiology; 46: 225-233.
14. Jabr RI, Gorog DA, Tanno M, Fisher SG, Cao XB, Bellahcene M, Dighe K, Kabir AM, Quinlan RA, Kato K, Gaestel M, Marber MS, Heads RJ (2009). MAPKAPK-2 modulates p38-MAPK localisation and small heat shock protein phosphorylation, but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia. Cell Stress and Chaperons; 14: 477-489.
15. Jabr RI, Wilson AJ, Riddervold MH, Jenkins AH, Perrino BA, Clapp LH (2007). Nuclear translocation of calcineurin Aß but not Aα by platelet-derived growth factor in rat aortic smooth muscle. American Journal of Physiology, Cell Physiology 2007: 292: C2213-2225.
16. Obasanjo-Blackshire K, Mesquita RS, Jabr RI, Molkentin J, Marber MS, Xia Y and Heads RJ (2006). Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: co-operation with Src tyrosine kinase. Cardiovascular Research: 71: 672-683.
17. Clapp LC, Jabr RI (2003). The BK channel: protective or detrimental in genetic hypertension? Circulation Research 2003: 93: 893-895.
18. Jabr RI, Wilson AJ, Clapp LH (2000). Calcium modulation of vascular smooth muscle ATP-sensitive K+ channels: Role of protein phosphatase-2B. Circulation Research: 87: 1019-1025.
19. Jabr RI, Yamazaki J, Hume JR (2000). Lysophosphatidylcholine triggers intracellular calcium release and activation of non-selective cation channels in renal arterial smooth muscle cells. Pflügers Archives; 439: 495-500.
20. Jabr RI, Toland H, Gelband CH, Wang XX, Hume JR (1997). Prominent role of sarcoplasmic reticulum Ca2+ stores in canine hypoxic pulmonary vasoconstriction. British Journal of Pharmacology: 122: 21-30.
21. Aiello ER, Jabr RI, Cole WC (1995). Arrhythmias and delayed recovery of cardiac action potential during reperfusion after ischemia: Role of oxygen radical-induced no-reflow phenomenon. Circulation Research: 77: 153-162.
22. Jabr RI, Cole WC (1995). Oxygen-derived free radical stress activates non-selective cation current in guinea-pig ventricular myocytes: Role of sulfhydryl groups. Circulation Research: 76: 812-824.
23. Jabr RI, Cole WC (1993). Alterations in electrical activity and membrane ionic currents induced by intracellular exposure of guinea-pig ventricular myocytes to oxy-radical stress. Circulation Research: 72: 1229-1244.
24. Jabr RI, Braveny P, Juggi JS (1988). Recovery of the conduction system from ischemic arrest and cardioplegia in perfused rat heart. Canadian Journal of Cardiology: 4: 90-96
Abstracts-Presented in national and international conferences:
2013Qasem AH, Fry CH, Mahmoudi M, Jabr RI. Assessment of Gap Junction Communication between Human Umbilical Vein Endothelial Cells and Monocytes In Response To Tumour Necrosis Factor (TNF-α). Presented in 1) British Society for Cardiovascular Research & Atherosclerosis Society (London, June 2013); and 2) International Unions of Physiological Society (IUPS) Congress, Birmingham, July 2013.
Waheed A, Salvage SC, Orlowski A, Fry CH, Michael A, Aiello A, Jabr RI. Low-Na increases ventricular gap junction resistivity and phosphorylation levels of connexion 43 at Serine 368: Possible synergistic interaction between calcineurin and protein kinase C. Presented in 1) International Society for Heart Research , The world Congress, San Diego, USA, July 2013; and 2) International Unions of Physiological Society (IUPS) Congress, Birmingham, July 2013.
Clayton J, Kitney D, Hague T, Talstaya A, Fry CH, Jabr RI. Modulation of urinary bladder smooth muscle contractility and mucosal ATP release by inhibition of intracellular protein phosphatases. International Unions of Physiological Society (IUPS) Congress, Birmingham, July 2013.
Kitney D, Hague T, Jabr RI, Fry CH. The influence of heating (37-50C) on spontaneous contractile activity of isolated bladder preparations. Presented in 1) International Unions of Physiological Society (IUPS) Congress, Birmingham, July 2013 and 2) ICS, Spain, August 2013.
2012Salvage SC, Roberts M, Fry CH, Jabr RI. Low Na+ solution increases gap junction resistivity and connexin 43 phosphorylation at serine 368 in guinea pig atrial myocardium: a role for calcineurin. Physiological Society meeting, Edinburgh, UK, July 2012.
2011Manazza A, Salvage S, Fry CH, Jabr RI. Measurement of myocardial sarcoplasmic resistivity by dielectrophoresis and impedance analysis. Physiological Society meeting, Oxford, 2011 as well as the European working group on cardiac cellular electrophysiology group , Oslo, Norway, 2011.
Salvage S, Dillon PS, Fry CH, Jabr RI. Interrelationship between conduction velocity, intracellular Ca2+ and gap junctions. Physiological Society meeting, Oxford, 2011 as well as the European working group on cardiac cellular electrophysiology group , Oslo, Norway, 2011.
2009Lin Y-C, Fry CH, Jabr RI. Modulation of staircase response in mouse myocardium by isoprenaline Physiological Society meeting (Dublin, 2009)
Jabr RI, Fry CH. Calcineurin slows myocardial action potential conduction during rapid pacing by increasing intercellular resistivity. American Heart Association (North American section; Baltimore, 2009)
Fry CH, Gray R, Dillon P, Jabr RI. Electrophysiological properties of human myocardium from hypertrophic cardiomyopathy. American Heart Association (North American section; Baltimore, 2009)
Dhillon PS, Gray R, Kojodjojo P, Jabr RI, Chowdhury RA, Fry CH, Peters NS. The Relationship Between Gap Junction Conductance and Conduction Velocity in Intact Myocardium Authors: Circulation 2009.
2007Jabr RI, Gray R, Patel PM, Peters NS, Fry C H. Calcinuerin slows the conduction velocity in isolated guinea-pig papillary muscle. Abstract submitted to the European Cardiac Arrhythmias Society Congress to be held in Marseille, France, April 2007.
Chowdhury R, Inuabasi L, Jabr R, Nicholson Thomas DM, Hall MC, Kirubakaran S, Dhillon P, Garratt CJ, Peters NS. Multiple anatomical changes in a goat model of atrial fibrillation are associated with conduction velocity abnormalities at 3 months. Abstract submitted to the Heart Rhythm Society, the 28th Annual Scientific Sessions to be held in Denver, Colorado May 2007.
2006Jabr RI, Gorog DA, Bellahcene M, Dighe K, Marber MS. MAPKAPK-2 does not mediate the injury associated with P38-MAPK activation during myocardial ischaemia: Possible role of nuclear translocation of phosphorylated P38-MAPK. Heart, 2006:92(1), no.017.
2005Mesquita RS, Jabr RI, Marber MS, Heads.RJ. Calcineurin and Protein Kinase C Regulate cyclooxygenase-2 expression in the heart. Presented in the 2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences-Targeting Heart Failure: New Science, NewTools, New Strategies Keystone, CO, USA, 2005.
Jabr RI, Gorog DA, Bellahcene M, Dighe K, Marber MS. MAPKAPK-2 does not mediate the injury associated with P38-MAPK activation during myocardial ischaemia. J Mol Cell Cardiol, 2005:38(6), no.90.
2004Jabr RI, Perrino B, Clapp LH: Nuclear translocation of calcineurin A ß isoform in response to platelet-derived growth factor in cultured rat aortic smooth muscle cells. Biophysical J, Feb 2004
2001Jabr RI, Wilson AW, Perrino BA, Clapp LH: Characterisation of calcineurin in rat aortic smooth muscle. Journal of Physiology, Bristol, 5-7 September, 2001: 536P.
Jabr RI, Wilson AW, Clapp LH: Ca2+ modulates vascular smooth muscle KATP channels via protein phosphatase-2B. Biophysical Journal 2001:80:627a.
2000Wilson AW, Jabr RI Clapp LH: Modulation of Glibenclamide-sensitive background K+ current by extracellular Ca2+ in isolated rat aortic smooth muscle cells. Journal of Physiology (London) 2000: 525P, 77P.
1999Al-Saeedi F, Juggi JS, Jabr RI, Al-Zaid NS: Intracellular kinetics of activator Ca2+ after ischemic preconditioning as determined by force-frequency relationship. J Mol Cell Cardiol, May 1999.
Ghadanfer E.A., Juggi JS, Jabr RI, Al-Zaid NS: Effect of preconditioning temperature on cardioprotection during global ischemia-reperfusion. J Mol Cell Cardiol, May 1999.
Jabr RI, Juggi JS, Joseph S, Barac-Nieto M: An increase in myocardial shortening velocity precedes arterial hypertension in spontaneously hypertensive rats. J Mol Cell Cardiol, May 1999.
1997Jabr RI, Hume JR: Effects of lysophosphatidylcholine on membrane currents in renal artery smooth muscle cells. Circulation 1997:94(8), pp1I-353, 2060.
Jabr RI, Hume JR: Prominent role of sarcoplasmic reticulum Ca2+ stores in canine hypoxic pulmonary vasoconstriction. Biophysical Journal 1997:72(2), pp. A184.
1996Jabr RI, Ahn DS, Hume JR: Characterization of three types of delayed rectifier potassium channels in canine pulmonary artery smooth muscle cells. Biophysical Journal Feb 1996:70(2), pp. A188.
1995Cole WC, Jabr RI, Aiello AE, Morales E: Cardiac non-selective cation current activated by oxy-radical stress and lysophosphatidylcholine: Voltage-dependence and block by Ni2+. Biophysical Journal 1995:68:A210.
1994Aiello EA, Jabr RI, Cole WC: Cardiac action potential shortening and arrhythmias during reperfusion after ischemia: Role of coronary vasoconstriction due to oxy-radical stress. Biophysical Journal 1994:66:A83.
Jabr RI, Cole WC: Oxygen-derived free -radical stress activates non-selective cation current in guinea-pig ventricular myocytes: Role of sulfhydryl groups. Biophysical Journal1994:66:A434.
Jabr RI, Leblanc N, Cole WC: Abnormal Ca2+ release activates Ca2+ -activated K+ channels in rabbit coronary myocytes during oxygen radicals stress. International Symposium on Resistance Arteries, Vermont, USA,1994.
1993Jabr RI, Cole WC: Oxygen radicals stimulates Na+/Ca2+ exchange and non-selective cation currents in guinea-pig ventricular myocytes. Biophysical Journal 1993:64:A397: 227.
1992Sigurdsson S, Jabr RI, Miller AL, Stephens NL, Cole WC: Whole-cell and single channel K+ currents in isolated canine bronchial smooth muscle cells. Biophysical Journal 1992:61:A251: 1446.
Jabr RI, Leblanc N, Cole WC: Abnormal sarcoplasmic reticulum (SR) Ca2+ release may mediate activation of Ca2+-dependent K+ current in coronary myocytes during oxygen-radical stress. Biophysical Journal 1992:61: A433: 2490.
1991Jabr RI, Cole WC: Effects of oxygen radicals on electrical activity and membrane currents in heart are mediated by abnormal Ca2+ release from sarcoplasmic reticulum. Circulation 1991:2:II-283; 1127.
1990Cole WC, McPherson CD, Jabr RI, Miller AL: Alterations in action potentials and contraction associated with perfusion of guinea-pig right ventricle: Protection by oxy-radical scavengers. Journal of Molecular and Cellular Cardiology 1990:22(suppl 1):S40.
Jabr RI, Cole WC: Alterations in electrical activity and membrane ionic currents after exposure of guinea-pig ventricular myocytes to oxy-radical. Journal of Molecular and Cellular Cardiology 1990:22(suppl 1):S35.
1987Jabr RI, Braveny P, Juggi JS: Preservation of the conduction system during ischemic heart arrest and cardioplegia. PACE 1987:10(3):598.
1986Braveny P, Juggi JS, Jabr RI: Post-arrest electrical instability of perfused rat heart. Journal of Molecular and Cellular Cardiology 1986:18(suppl 21): 274.