Dr Ralph Manders


Lecturer in Exercise Physiology
+44 (0)1483 688668
29 PG 00
9:00-18:00

Biography

Areas of specialism

Exercise Physiology; Sport Science; Muscle Metabolism; Nutrition; Glycemic Control

University roles and responsibilities

  • Co-Programme Leader Sport & Exercise Science BSc.
  • Admissions Tutor Sport & Exercise Science BSc.
  • Radiation Protection Supervisor FHMS

Research

Research interests

My teaching

Courses I teach on

Undergraduate

Supervision

Postgraduate research supervision

Postgraduate research supervision

My publications

Highlights

Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years.

Andrea L Darling et al. https://link.springer.com/article/10.1007%2Fs00198-019-04933-8

Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study.

Jordan L. Rees et al. https://link.springer.com/article/10.1007%2Fs00592-019-01358-x

 

Prehabilitation for adults diagnosed with cancer: A systematic review of long-term physical function, nutrition and patient-reported outcomes.

Sara Faithfull et al. https://onlinelibrary.wiley.com/doi/full/10.1111/ecc.13023

Publications

  • Rees, J.L., C.R. Chang, M.E. Francois, A. Marcotte-Chenard, A. Fontvieille, N.D. Klaprat, R.A. Dyck, D.R. Funk, G. Snydmiller, K. Bastell, F.E. Godkin, M.C. Dube, E. Riesco, J.M. McGavock, J.E. Yardley, R.J. Sigal, M.J. Gibala, S.J. Weisnagel, C.M. Prado, M. Jung, R. Manders, T. Lee, J. Singer, N.G. Boule, and J.P. Little, Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study. Acta Diabetol, 2019.
  • Lemanska, A., K. Poole, B.A. Griffin, R. Manders, J.M. Saxton, L. Turner, J. Wainwright, and S. Faithfull, Community pharmacy lifestyle intervention to increase physical activity and improve cardiovascular health of men with prostate cancer: a phase II feasibility study. BMJ Open, 2019. 9(6): p. e025114.
  • Lemanska, A., K. Poole, J.J. Aning, B.A. Griffin, R. Manders, J.M. Saxton, J. Wainwright, and S. Faithfull, The Siconolfi step test: a valid and reliable assessment of cardiopulmonary fitness in older men with prostate cancer. Eur Rev Aging Phys Act, 2019. 16: p. 1.
  • Faithfull, S., L. Turner, K. Poole, M. Joy, R. Manders, J. Weprin, K. Winters-Stone, and J. Saxton, Prehabilitation for adults diagnosed with cancer: A systematic review of long-term physical function, nutrition and patient-reported outcomes. Eur J Cancer Care (Engl), 2019: p. e13023.
  • Darling, A.L., R.J.F. Manders, S. Sahni, K. Zhu, C.E. Hewitt, R.L. Prince, D.J. Millward, and S.A. Lanham-New, Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years. Osteoporosis International, 2019.
  • Chalil, S., N. Pierre, A.D. Bakker, R.J. Manders, A. Pletsers, M. Francaux, J. Klein-Nulend, R.T. Jaspers, and L. Deldicque, Aging related ER stress is not responsible for anabolic resistance in mouse skeletal muscle. Biochem Biophys Res Commun, 2015. 468(4): p. 702-7.
  • Chalil, S., R.T. Jaspers, R.J. Manders, J. Klein-Nulend, A.D. Bakker, and L. Deldicque, Increased endoplasmic reticulum stress in mouse osteocytes with aging alters Cox-2 response to mechanical stimuli. Calcif Tissue Int, 2015. 96(2): p. 123-8.
  • Manders, R.J., D. Hansen, A.H. Zorenc, P. Dendale, J. Kloek, W.H. Saris, and L.J. van Loon, Protein co-ingestion strongly increases postprandial insulin secretion in type 2 diabetes patients. J Med Food, 2014. 17(7): p. 758-63.
  • Little, J.P., M.E. Jung, A.E. Wright, W. Wright, and R.J. Manders, Effects of high-intensity interval exercise versus continuous moderate-intensity exercise on postprandial glycemic control assessed by continuous glucose monitoring in obese adults. Appl Physiol Nutr Metab, 2014. 39(7): p. 835-41.
  • Van Dijk, J.W., R.J. Manders, E.E. Canfora, W.V. Mechelen, F. Hartgens, C.D. Stehouwer, and L.J. Van Loon, Exercise and 24-h glycemic control: equal effects for all type 2 diabetes patients? Med Sci Sports Exerc, 2013. 45(4): p. 628-35.
  • Van Dijk, J.W., R.J. Manders, K. Tummers, A.G. Bonomi, C.D. Stehouwer, F. Hartgens, and L.J. van Loon, Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients. Diabetologia, 2012. 55(5): p. 1273-82.
  • Manders, R.J., J.P. Little, S.C. Forbes, and D.G. Candow, Insulinotropic and muscle protein synthetic effects of branched-chain amino acids: potential therapy for type 2 diabetes and sarcopenia. Nutrients, 2012. 4(11): p. 1664-78.
  • Manders, R.J., J.W. van Dijk, F. Hartgens, C.D. Stehouwer, S.F. Praet, and L.J. van Loon, Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Res Clin Pract, 2011. 93(1): p. 31-7.
  • Manders, R.J., J.W. Van Dijk, and L.J. van Loon, Low-intensity exercise reduces the prevalence of hyperglycemia in type 2 diabetes. Med Sci Sports Exerc, 2010. 42(2): p. 219-25.
  • Weseler, A.R., L. Geraets, H.J. Moonen, R.J. Manders, L.J. van Loon, H.J. Pennings, E.F. Wouters, A. Bast, and G.J. Hageman, Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes. J Nutr, 2009. 139(5): p. 952-7.
  • Manders, R.J., S.F. Praet, M.H. Vikstrom, W.H. Saris, and L.J. van Loon, Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients. Eur J Clin Nutr, 2009. 63: p. 121-6.
  • Manders, R.J., B. Pennings, C.P. Beckers, T.I. Aipassa, and L.J. van Loon, Prevalence of daily hyperglycemia in obese type 2 diabetic men compared with that in lean and obese normoglycemic men: effect of consumption of a sucrose-containing beverage. Am J Clin Nutr, 2009. 90(3): p. 511-8.
  • Manders, R. and L.J. Van Loon, Protein supplementation as a dietary strategy to improve glycemic control in type 2 diabetes mellitus Netherlands Journal of Diabetologia, 2009(2).
  • Hansen, D., P. Dendale, R.A. Jonkers, M. Beelen, R.J. Manders, L. Corluy, A. Mullens, J. Berger, R. Meeusen, and L.J. van Loon, Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients. Diabetologia, 2009.
  • Manders, R.J., R. Koopman, M. Beelen, A.P. Gijsen, W.K. Wodzig, W.H. Saris, and L.J. van Loon, The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetes. J Nutr, 2008. 138(6): p. 1079-85.
  • Praet, S.F., R.J. Manders, R.C. Meex, A.G. Lieverse, C.D. Stehouwer, H. Kuipers, H.A. Keizer, and L.J. van Loon, Glycemic instability is an underestimated problem in type 2 diabetes. Clin Sci (Lond), 2006. 111(2): p. 119-26.
  • Praet, S.F., R.J. Manders, A.G. Lieverse, H. Kuipers, C.D. Stehouwer, H.A. Keizer, and L.J. van Loon, Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes. Med Sci Sports Exerc, 2006. 38(12): p. 2037-44.
  • Manders, R.J., S.F. Praet, R.C. Meex, R. Koopman, A.L. de Roos, A.J. Wagenmakers, W.H. Saris, and L.J. van Loon, Protein hydrolysate/leucine co-ingestion reduces the prevalence of hyperglycemia in type 2 diabetic patients. Diabetes Care, 2006. 29(12): p. 2721-2.
  • Manders, R.J., R. Koopman, W.E. Sluijsmans, R. van den Berg, K. Verbeek, W.H. Saris, A.J. Wagenmakers, and L.J. van Loon, Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces post-prandial blood glucose excursions in Type 2 diabetic men. J Nutr, 2006. 136(5): p. 1294-9.
  • Koopman, R., L. Verdijk, R.J. Manders, A.P. Gijsen, M. Gorselink, E. Pijpers, A.J. Wagenmakers, and L.J. van Loon, Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am J Clin Nutr, 2006. 84(3): p. 623-32.
  • Koopman, R., R.J. Manders, R.A. Jonkers, G.B. Hul, H. Kuipers, and L.J. van Loon, Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males. Eur J Appl Physiol, 2006. 96(5): p. 525-34.
  • Kaastra, B., R.J.F. Manders, E. van Breda , A. Kies, A.E. Jeukendrup, H.A. Keizer, H. Kuipers, and L.J. van Loon, Effects of increasing insulin secretion on acute postexercise blood glucose disposal. Med Sci Sports Exerc, 2006. 38(2): p. 197-403.
  • van Loon, L.J., R.J. Manders, R. Koopman, B. Kaastra, J.H. Stegen, A.P. Gijsen, W.H. Saris, and H.A. Keizer, Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients. Diabetologia, 2005. 48(10): p. 2097-107.
  • Punyadeera, C., A.H. Zorenc, R. Koopman, A.J. McAinch, E. Smit, R. Manders, H.A. Keizer, D. Cameron-Smith, and L.J. van Loon, The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle. Eur J Endocrinol, 2005. 152(3): p. 427-36.
  • Manders, R.J., A.J. Wagenmakers, R. Koopman, A.H. Zorenc, P.P. Menheere, N.C. Schaper, W.H. Saris, and L.J. van Loon, Co-ingestion of a protein hydrolysate and amino acid mixture with carbohydrate improves plasma glucose disposal in patients with type 2 diabetes. Am J Clin Nutr, 2005. 82(1): p. 76-83.
  • Koopman, R., A.J. Wagenmakers, R.J. Manders, A.H. Zorenc, J.M. Senden, M. Gorselink, H.A. Keizer, and L.J. van Loon, Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab, 2005. 288(4): p. E645-53.
  • Koopman, R., R.J. Manders, A.H. Zorenc, G.B. Hul, H. Kuipers, H.A. Keizer, and L.J. van Loon, A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men. Eur J Appl Physiol, 2005. 94(1-2): p. 180-7.
  • Koopman, R., R.J. Manders, R.A. Jonkers, G.B. Hul, H. Kuipers, and L.J. van Loon, Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males. Eur J Appl Physiol, 2005: p. 1-10.
  • van Loon, L.J., R. Koopman, R. Manders, W. van der Weegen, G.P. van Kranenburg, and H.A. Keizer, Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes. Am J Physiol Endocrinol Metab, 2004. 287(3): p. E558-65.