Ralph Manders

Dr Ralph Manders

Lecturer in Exercise Physiology
+44 (0)1483 688668
Sport & Exercise Science BSc.
29 PG 00
9:00-18:00

Biography

Areas of specialism

Exercise Physiology; Sport Science; Muscle Metabolism; Nutrition; Glycemic Control

University roles and responsibilities

  • Co-Programme Leader Sport & Exercise Science BSc.
  • Admissions Tutor Sport & Exercise Science BSc.
  • Radiation Protection Supervisor FHMS

Affiliations and memberships

European College of Sport Science
Member
European Association for the Study of Diabetes
Member
European Society of Clinical Nutrition and Metabolism
Member

Research

Research interests

My teaching

Courses I teach on

Undergraduate

Supervision

Postgraduate research supervision

Postgraduate research supervision

My publications

Highlights

Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years.

Andrea L Darling et al. https://link.springer.com/article/10.1007%2Fs00198-019-04933-8

Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study.

Jordan L. Rees et al. https://link.springer.com/article/10.1007%2Fs00592-019-01358-x

 

Prehabilitation for adults diagnosed with cancer: A systematic review of long-term physical function, nutrition and patient-reported outcomes.

Sara Faithfull et al. https://onlinelibrary.wiley.com/doi/full/10.1111/ecc.13023

Publications

  • Rees, J.L., C.R. Chang, M.E. Francois, A. Marcotte-Chenard, A. Fontvieille, N.D. Klaprat, R.A. Dyck, D.R. Funk, G. Snydmiller, K. Bastell, F.E. Godkin, M.C. Dube, E. Riesco, J.M. McGavock, J.E. Yardley, R.J. Sigal, M.J. Gibala, S.J. Weisnagel, C.M. Prado, M. Jung, R. Manders, T. Lee, J. Singer, N.G. Boule, and J.P. Little, Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study. Acta Diabetol, 2019.
  • Lemanska, A., K. Poole, B.A. Griffin, R. Manders, J.M. Saxton, L. Turner, J. Wainwright, and S. Faithfull, Community pharmacy lifestyle intervention to increase physical activity and improve cardiovascular health of men with prostate cancer: a phase II feasibility study. BMJ Open, 2019. 9(6): p. e025114.
  • Lemanska, A., K. Poole, J.J. Aning, B.A. Griffin, R. Manders, J.M. Saxton, J. Wainwright, and S. Faithfull, The Siconolfi step test: a valid and reliable assessment of cardiopulmonary fitness in older men with prostate cancer. Eur Rev Aging Phys Act, 2019. 16: p. 1.
  • Faithfull, S., L. Turner, K. Poole, M. Joy, R. Manders, J. Weprin, K. Winters-Stone, and J. Saxton, Prehabilitation for adults diagnosed with cancer: A systematic review of long-term physical function, nutrition and patient-reported outcomes. Eur J Cancer Care (Engl), 2019: p. e13023.
  • Darling, A.L., R.J.F. Manders, S. Sahni, K. Zhu, C.E. Hewitt, R.L. Prince, D.J. Millward, and S.A. Lanham-New, Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years. Osteoporosis International, 2019.
  • Chalil, S., N. Pierre, A.D. Bakker, R.J. Manders, A. Pletsers, M. Francaux, J. Klein-Nulend, R.T. Jaspers, and L. Deldicque, Aging related ER stress is not responsible for anabolic resistance in mouse skeletal muscle. Biochem Biophys Res Commun, 2015. 468(4): p. 702-7.
  • Chalil, S., R.T. Jaspers, R.J. Manders, J. Klein-Nulend, A.D. Bakker, and L. Deldicque, Increased endoplasmic reticulum stress in mouse osteocytes with aging alters Cox-2 response to mechanical stimuli. Calcif Tissue Int, 2015. 96(2): p. 123-8.
  • Manders, R.J., D. Hansen, A.H. Zorenc, P. Dendale, J. Kloek, W.H. Saris, and L.J. van Loon, Protein co-ingestion strongly increases postprandial insulin secretion in type 2 diabetes patients. J Med Food, 2014. 17(7): p. 758-63.
  • Little, J.P., M.E. Jung, A.E. Wright, W. Wright, and R.J. Manders, Effects of high-intensity interval exercise versus continuous moderate-intensity exercise on postprandial glycemic control assessed by continuous glucose monitoring in obese adults. Appl Physiol Nutr Metab, 2014. 39(7): p. 835-41.
  • Van Dijk, J.W., R.J. Manders, E.E. Canfora, W.V. Mechelen, F. Hartgens, C.D. Stehouwer, and L.J. Van Loon, Exercise and 24-h glycemic control: equal effects for all type 2 diabetes patients? Med Sci Sports Exerc, 2013. 45(4): p. 628-35.
  • Van Dijk, J.W., R.J. Manders, K. Tummers, A.G. Bonomi, C.D. Stehouwer, F. Hartgens, and L.J. van Loon, Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients. Diabetologia, 2012. 55(5): p. 1273-82.
  • Manders, R.J., J.P. Little, S.C. Forbes, and D.G. Candow, Insulinotropic and muscle protein synthetic effects of branched-chain amino acids: potential therapy for type 2 diabetes and sarcopenia. Nutrients, 2012. 4(11): p. 1664-78.
  • Manders, R.J., J.W. van Dijk, F. Hartgens, C.D. Stehouwer, S.F. Praet, and L.J. van Loon, Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Res Clin Pract, 2011. 93(1): p. 31-7.
  • Manders, R.J., J.W. Van Dijk, and L.J. van Loon, Low-intensity exercise reduces the prevalence of hyperglycemia in type 2 diabetes. Med Sci Sports Exerc, 2010. 42(2): p. 219-25.
  • Weseler, A.R., L. Geraets, H.J. Moonen, R.J. Manders, L.J. van Loon, H.J. Pennings, E.F. Wouters, A. Bast, and G.J. Hageman, Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes. J Nutr, 2009. 139(5): p. 952-7.
  • Manders, R.J., S.F. Praet, M.H. Vikstrom, W.H. Saris, and L.J. van Loon, Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients. Eur J Clin Nutr, 2009. 63: p. 121-6.
  • Manders, R.J., B. Pennings, C.P. Beckers, T.I. Aipassa, and L.J. van Loon, Prevalence of daily hyperglycemia in obese type 2 diabetic men compared with that in lean and obese normoglycemic men: effect of consumption of a sucrose-containing beverage. Am J Clin Nutr, 2009. 90(3): p. 511-8.
  • Manders, R. and L.J. Van Loon, Protein supplementation as a dietary strategy to improve glycemic control in type 2 diabetes mellitus Netherlands Journal of Diabetologia, 2009(2).
  • Hansen, D., P. Dendale, R.A. Jonkers, M. Beelen, R.J. Manders, L. Corluy, A. Mullens, J. Berger, R. Meeusen, and L.J. van Loon, Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients. Diabetologia, 2009.
  • Manders, R.J., R. Koopman, M. Beelen, A.P. Gijsen, W.K. Wodzig, W.H. Saris, and L.J. van Loon, The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetes. J Nutr, 2008. 138(6): p. 1079-85.
  • Praet, S.F., R.J. Manders, R.C. Meex, A.G. Lieverse, C.D. Stehouwer, H. Kuipers, H.A. Keizer, and L.J. van Loon, Glycemic instability is an underestimated problem in type 2 diabetes. Clin Sci (Lond), 2006. 111(2): p. 119-26.
  • Praet, S.F., R.J. Manders, A.G. Lieverse, H. Kuipers, C.D. Stehouwer, H.A. Keizer, and L.J. van Loon, Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes. Med Sci Sports Exerc, 2006. 38(12): p. 2037-44.
  • Manders, R.J., S.F. Praet, R.C. Meex, R. Koopman, A.L. de Roos, A.J. Wagenmakers, W.H. Saris, and L.J. van Loon, Protein hydrolysate/leucine co-ingestion reduces the prevalence of hyperglycemia in type 2 diabetic patients. Diabetes Care, 2006. 29(12): p. 2721-2.
  • Manders, R.J., R. Koopman, W.E. Sluijsmans, R. van den Berg, K. Verbeek, W.H. Saris, A.J. Wagenmakers, and L.J. van Loon, Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces post-prandial blood glucose excursions in Type 2 diabetic men. J Nutr, 2006. 136(5): p. 1294-9.
  • Koopman, R., L. Verdijk, R.J. Manders, A.P. Gijsen, M. Gorselink, E. Pijpers, A.J. Wagenmakers, and L.J. van Loon, Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am J Clin Nutr, 2006. 84(3): p. 623-32.
  • Koopman, R., R.J. Manders, R.A. Jonkers, G.B. Hul, H. Kuipers, and L.J. van Loon, Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males. Eur J Appl Physiol, 2006. 96(5): p. 525-34.
  • Kaastra, B., R.J.F. Manders, E. van Breda , A. Kies, A.E. Jeukendrup, H.A. Keizer, H. Kuipers, and L.J. van Loon, Effects of increasing insulin secretion on acute postexercise blood glucose disposal. Med Sci Sports Exerc, 2006. 38(2): p. 197-403.
  • van Loon, L.J., R.J. Manders, R. Koopman, B. Kaastra, J.H. Stegen, A.P. Gijsen, W.H. Saris, and H.A. Keizer, Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients. Diabetologia, 2005. 48(10): p. 2097-107.
  • Punyadeera, C., A.H. Zorenc, R. Koopman, A.J. McAinch, E. Smit, R. Manders, H.A. Keizer, D. Cameron-Smith, and L.J. van Loon, The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle. Eur J Endocrinol, 2005. 152(3): p. 427-36.
  • Manders, R.J., A.J. Wagenmakers, R. Koopman, A.H. Zorenc, P.P. Menheere, N.C. Schaper, W.H. Saris, and L.J. van Loon, Co-ingestion of a protein hydrolysate and amino acid mixture with carbohydrate improves plasma glucose disposal in patients with type 2 diabetes. Am J Clin Nutr, 2005. 82(1): p. 76-83.
  • Koopman, R., A.J. Wagenmakers, R.J. Manders, A.H. Zorenc, J.M. Senden, M. Gorselink, H.A. Keizer, and L.J. van Loon, Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab, 2005. 288(4): p. E645-53.
  • Koopman, R., R.J. Manders, A.H. Zorenc, G.B. Hul, H. Kuipers, H.A. Keizer, and L.J. van Loon, A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men. Eur J Appl Physiol, 2005. 94(1-2): p. 180-7.
  • Koopman, R., R.J. Manders, R.A. Jonkers, G.B. Hul, H. Kuipers, and L.J. van Loon, Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males. Eur J Appl Physiol, 2005: p. 1-10.
  • van Loon, L.J., R. Koopman, R. Manders, W. van der Weegen, G.P. van Kranenburg, and H.A. Keizer, Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes. Am J Physiol Endocrinol Metab, 2004. 287(3): p. E558-65.