Dr Ralph Manders
Biography
Ralph Manders is lecturer in Exercise Physiology at the department of Nutritional Sciences and Programme director for the BSc. in Sport and Exercise Science at the University of Surrey, in Guildford, United Kingdom.
Having received his Masters degree in Movement Sciences in 2003 from the Faculty of Health, Medicine & Life Sciences at Maastricht University, the Netherlands, he then went on to complete a PhD focusing on the insulinotropic and anabolic properties of dietary protein in type 2 diabetes. Dr Manders has been a post-doctoral researcher at both the faculties of Health, Medicine & Life Sciences at Maastricht University, the Netherlands and the Faculty of Kinesiology, KU Leuven, Belgium focussing on the beneficial health effects of exercise training and dietary modulation in type 2 diabetes and the elderly, and he has also spent time as a visiting researcher at Prof. Martin Gibala’s lab at MacMaster University, Canada. Next to his research activities Dr Manders has been involved in the supervision of several amateur and professional athletes with regard to performance and nutrition.
Areas of specialism
Exercise Physiology;
Sport Science;
Muscle Metabolism;
Nutrition;
Glycemic Control
University roles and responsibilities
- Co-Programme Leader Sport & Exercise Science BSc.
- Admissions Tutor Sport & Exercise Science BSc.
- Radiation Protection Supervisor FHMS
Research
Research interests
On-going research interests are in the field of exercise training, nutrition, and energy/substrate metabolism and their role in improving health in (sub) clinical populations but also how these factors can improve exercise capacity and performance in athletes. These effects are investigated on a whole-body, tissue and cellular level using biochemical and histochemical analysis of skeletal muscles biopsies and stable isotope methodology to determine substrate metabolism and whole body and skeletal muscle protein synthesis. With the use of continuous glucose monitoring devices (CGMS) the impact of different exercise and dietary modulations on the level of glycemic control in (pre) diabetic populations as well as in athletes are studied.
My current research projects include:
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INTense Exercise foR surVivAL Among Men With Metastatic Castrate-Resistant Prostate Cancer (INTERVAL)
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The interrelationship between Vitamin D, Bone, Illness, Injury and its Impact on Exercise Performance (The D-BIICEP Study)
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Performance nutrition for injury and recovery in elite rugby union
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TrueNTH Exercise and Diet Project
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A Multimodal Approach to Improve Fitness and Surgical Outcomes for Patients Undergoing Pancreatic Resection
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PARTNER study : PARents Together in Nutrition Exercise inteRconception Study
- Nutritional supplementation in overcoming anabolic resistance in the elderly
- Exercise interventions aimed at improving glycemic control in type 2 diabetes patients
My teaching
I have been involved in undergraduate and postgraduate exercise, nutrition and health education for over 10 years at well-known universities in the Netherlands, Belgium and the UK. Next to this I have supervised and trained several PhD students.
Together with my colleagues from the School of Biosciences and Medicine and the Surrey Sports Park we developed the new BSc in Sport and Exercise Sciences. The excellent research and teaching facilities closely affiliated with sports and exercise sciences together with our dedication and passion for exercise and health ensure that this new program will be an excellent place for students to receive thorough training in the field of exercise physiology and sports sciences.
Courses I teach on
Supervision
Postgraduate research supervision
Saskia Louise Wilson-Barnes:
The interrelationship between Vitamin D, Bone, Illness, Injury and its Impact on Exercise Performance (The D-BIICEP Study)
Postgraduate research supervision
Victoria Anne Benford:
Performance nutrition for injury and recovery in elite rugby union
My publications
Publications
1. van Loon, L.J., R. Koopman, R.J. Manders, W. van der Weegen, G.P. van Kranenburg, and H.A. Keizer (2004) Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes. Am J Physiol Endocrinol Metab, 287(3):E558-65.
2. Koopman, R., R.J. Manders, A.H. Zorenc, G.B. Hul, H. Kuipers, H.A. Keizer, and L.J. van Loon (2005) A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men. Eur J Appl Physiol, 94(1-2):180-7.
3. Koopman, R., A.J. Wagenmakers, R.J. Manders, A.H. Zorenc, J.M. Senden, M. Gorselink, H.A. Keizer, and L.J. van Loon (2005) Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab, 288(4):E645-53.
4. Manders, R.J., A.J. Wagenmakers, R. Koopman, A.H. Zorenc, P.P. Menheere, N.C. Schaper, W.H. Saris, and L.J. van Loon (2005) Co-ingestion of a protein hydrolysate and amino acid mixture with carbohydrate improves plasma glucose disposal in patients with type 2 diabetes. Am J Clin Nutr, 82(1):76-83.
5. Punyadeera, C., A.H. Zorenc, R. Koopman, A.J. McAinch, E. Smit, R.J. Manders, H.A. Keizer, D. Cameron-Smith, and L.J. van Loon (2005) The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle. Eur J Endocrinol, 152(3):427-36.
6. van Loon, L.J., R.J. Manders, R. Koopman, B. Kaastra, J.H. Stegen, A.P. Gijsen, W.H. Saris, and H.A. Keizer (2005) Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients. Diabetologia, 48(10):2097-107.
7. Kaastra, B., R.J. Manders, E. Van Breda, A. Kies, A.E. Jeukendrup, H.A. Keizer, H. Kuipers, and L.J. van Loon (2006) Effects of increasing insulin secretion on acute postexercise blood glucose disposal. Med Sci Sports Exerc, 38(2):268-75.
8. Koopman, R., R.J. Manders, R.A. Jonkers, G.B. Hul, H. Kuipers, and L.J. van Loon (2006) Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males. Eur J Appl Physiol, 96(5):525-34.
9. Koopman, R., L. Verdijk, R.J. Manders, A.P. Gijsen, M. Gorselink, E. Pijpers, A.J. Wagenmakers, and L.J. van Loon (2006) Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am J Clin Nutr, 84(3):623-32.
10. Manders, R.J., R. Koopman, W.E. Sluijsmans, R. van den Berg, K. Verbeek, W.H. Saris, A.J. Wagenmakers, and L.J. van Loon (2006) Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in Type 2 diabetic men. J Nutr, 136(5): 1294-9.
11. Manders, R.J., S.F. Praet, R.C. Meex, R. Koopman, A.L. de Roos, A.J. Wagenmakers, W.H. Saris, and L.J. van Loon (2006) Protein hydrolysate/leucine co-ingestion reduces the prevalence of hyperglycemia in type 2 diabetic patients. Diabetes Care, 29(12):2721-2.
12. Praet, S.F., R.J. Manders, A.G. Lieverse, H. Kuipers, C.D. Stehouwer, H.A. Keizer, and L.J. van Loon (2006) Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes. Med Sci Sports Exerc, 38(12):2037-44.
13. Praet, S.F., R.J. Manders, R.C. Meex, A.G. Lieverse, C.D. Stehouwer, H. Kuipers, H.A. Keizer, and L.J. van Loon, (2006) Glycaemic instability is an underestimated problem in Type II diabetes. Clin Sci (Lond), 111(2):119-26.
14. Manders, R.J., R. Koopman, M. Beelen, A.P. Gijsen, W.K. Wodzig, W.H. Saris, and L.J. van Loon (2008) The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetes. J Nutr, 138(6):1079-85.
15. Hansen, D., P. Dendale, R.A. Jonkers, M. Beelen, R.J. Manders, L. Corluy, A. Mullens, J. Berger, R. Meeusen, and L.J. van Loon (2009) Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients. Diabetologia, 52(9): 1789-97.
16. Manders, R.J. and L.J. Van Loon (2009) Protein supplementation as a dietary strategy to improve glycemic control in type 2 diabetes mellitus Netherlands Journal of Diabetologia, 2:49-56.
17. Weseler, A.R., L. Geraets, H.J. Moonen, R.J. Manders, L.J. van Loon, H.J. Pennings, E.F. Wouters, A. Bast, and G.J. Hageman (2009) Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes. J Nutr, 139(5):952-7.
18. Manders, R.J., S.F. Praet, M.H. Vikstrom, W.H. Saris, and L.J. van Loon (2009) Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients. Eur J Clin Nutr, 63(1):121-6.
19. Manders, R.J., B. Pennings, C.P. Beckers, T.I. Aipassa, and L.J. van Loon (2009) Prevalence of daily hyperglycemia in obese type 2 diabetic men compared with that in lean and obese normoglycemic men: effect of consumption of a sucrose-containing beverage. Am J Clin Nutr 90:511-8.
20. Manders, R.J., J. van Dijk, and L.J. Van Loon (2010) Low-Intensity exercise reduces the prevalence of hyperglycemia in type 2 diabetes. Med Sci Sports Exerc, 42:219-25.
21. Manders, R.J., J.W. van Dijk, F. Hartgens, C.D. Stehouwer, S.F.E. Praet, and L.J.C. van Loon (2011) Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Research and Clinical Practice, 93:31-7.
22. van Dijk, J.W., R.J. Manders, K. Tummers, A.G. Bonomi, C.D. Stehouwer, F. Hartgens, and L.J.C. van Loon (2012) Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients. Diabetologia, 55(5):1273-82.
23. Manders, R.J., J.P. Little, S.C. Forbes and D.G. Candow (2012) Insulinotropic and Muscle Protein Synthetic Effects of Branched-Chain Amino Acids: Potential Therapy for Type 2 Diabetes and Sarcopenia. Nutrients, 4(11), 1664-1678.
24. Van Dijk JW, R.J. Manders, E.E. Canfora, W.V. Mechelen, F. Hartgens, C.D. Stehouwer, and L.J.C. van Loon (2013) Exercise and 24-h glycemic control: equal effects for all type 2 diabetes patients? Med Sci Sports Exerc, 45(4):628-35.
25. Manders, R.J., D. Hansen, A.H. Zorenc, P. Dendale, J. Kloek, W.H. Saris, and Luc J.C. van Loon (2014) Protein co-ingestion strongly increases postprandial insulin secretion in type 2 diabetes patients. Journal of Medicinal Food, Jul;17(7):758-63.26. Little J.P, Jung M.E, Wright A.E, Wright W, Manders R.J. (2014) Effects of high-intensity interval exercise versus continuous moderate-intensity exercise on postprandial glycemic control assessed by continuous glucose monitoring in obese adults. Appl Physiol Nutr Metab Jul;39(7):835-41
27. Chalil S, Jaspers R.T., Manders R.J., Klein-Nulend J, Bakker AD, Deldicque L. (2015) Increased endoplasmic reticulum stress in mouse osteocytes with aging alters Cox-2 response to mechanical stimuli. Calcif Tissue Int., Feb;96(2):123-8.