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Chris Fry



Previous positions

1995-2008 Professor of Cell Physiology, Institute of Urology, University College London

1994-1995 Reader in Cell Physiology, Institute of Urology & Nephrology, University College London.

1991-1993 Reader in Cell Physiology, Division of Physiology, UMDS, University of London.

Vice-chairman, Division of Physiology, UMDS, London University

1987-1991 Senior Lecturer in Physiology, UMDS, London University

1979-1987 Lecturer in Physiology. St Thomas' Hospital Medical School (later UMDS), London University.

1978-1979 British Heart Foundation Lecturer in Cardiac Physiology. Cardiothoracic Institute, London.

1977-1978 Research Assistant. Cardiothoracic Institute, London.

1976-1977 Teaching Assistant. Physiologisches Institüt, University of Bern, Switzerland.

1975-1976 Royal Society Fellow. Physiologisches Institüt, University of Bern, Switzerland.

Research interests

Smooth and cardiac muscle biophysics and excitation-contraction coupling.

Research collaborations

Dr T Kanai, Dept Medicine, University of Pittsburgh

Dr L Birder, Dept Medicine, University of Pittsburgh

Prof M Drake, Bristol Urological Institute


Physiology, all aspects to BMS 1032, BMS 2038

MSc Pharmaceutical Medicine and Clinical Pharmacology, biostatistics

MSc Nutritional Medicine; electrolyte regulation

Departmental duties

PG advisor MD students

Cardiovascular CAG university representative

Cardiovascular & Cancer research group pleader


Physiological Society

American Physiological Society

International Continence Society

British Society for Cardiovascular Research

Additional Information


Ministry of Defence: Member, Research Ethics Committee

The Royal College of Surgeons of England: Member, Court of Examiners

External reviewer: Cambridge University; Physiology, Developmental Sciences and Neurosciences programmes

External examiner (MB BS, BSc Biomedical Sciences) St George's, University of London

My publications


Cellek S, Cameron NE, Cotter MA, Fry CH, Ilo D (2014). Microvascular dysfunction and efficacy of PDE5 inhibitors in BPH-LUTS. Nature (Urol), In the Press

Fry CH, Jabr RI (2014). T-type Ca2+ channels and the urinary and male genital tracts. Pflugers Arch. Jan 25.

Fry CH, Sahai A, Vahabi B, Kanai AJ, Birder LA (2014). What is the role for biomarkers for lower urinary tract disorders? ICI-RS. Neurourology and Urodynamics. Jan 16

Sui G, Fry CH, Montgomery B, Roberts M, Wu R, Wu C (2014). Purinergic and muscarinic modulation of ATP release from the urothelium and its paracrine actions. American Journal of Physiology, Renal Physiology; 306: F286-298

Dhillon PS, Gray R, Kojodjojo P, Jabr R, Chowdhury R, Fry CH, Peters NS (2013). Relationship between gap-junctional conductance and conduction velocity in mammalian myocardium. Circulation (Arrhythmias & Electrophysiology); 6: 1208-1214.

Jabr RI, Fry CH (2013). Animal models of lower urinary tract dysfunction. In: Animal models for the study of human disease ed M Conn, Elsevier.

Fry CH (2013). Obesity and the overactive bladder. Current bladder dysfunction reports.

Jones C, Kelliher L, Dickinson M, Riga A, Worthington T, Scott MJ, Vandrevala T, Fry CH, Karanjia N, Quiney N (2013). Randomized clinical trial on enhanced recovery versus standard care following open liver resection. British Journal of Surgery; 100: 1015-1024.

Dunning-Davies BM, Fry CH, Mansour D, Ferguson DR (2013). The regulation of ATP release from the urothelium by adenosine and transepithelial potential. BJU Internarional; 111; 505-513.

Young JS, Johnston L, Soubrane C, McCloskey KD, McMurray G, Eccles R, Fry CH (2013). The passive and active contractile properties of the neurogenic, underactive bladder. BJU International; 111: 355-361.

Fry CH, Salvage SC, Manazza A, Dupont E, Labeed FH, Hughes MP, Jabr RI (2012). Cytoplasm resistivity of mammalian atrial myocardium determined by dielectrophoresis and impedance methods. Biophysical Journal; 103: 2287-2294.

Fry CH, Young JS, Jabr RI, McCarthy C, Ikeda Y, Kanai AJ (2012). Modulation of spontaneous activity in the overactive bladder -the role of P2Y agonists. American Journal of Physiology; 302: F1447-1454.

Parsons BA, Drake MJ, Gammie, A, Fry CH, Vahabi B (2012). The validation of a functional, isolated bladder model from a large animal. Frontiers of Urology; 3:52. doi: 10.3389/fphar.2012.00052.

Birder LA, Ruggieri M, Takeda M, van Koeveringe G, Veltkamp S, Korstanje C, Parsons B, Fry CH (2012). How does the urothelium affect bladder function in health and disease? Neurourology and Urodynamics; 31: 293-299.

Young JS, Mathura R, Carew M, Fry CH (2012). Inhibition of stretch evoked ATP release from bladder mucosa by anticholinergic agents. BJU International Oct; 110(8 Pt B): E397-401.

Johnston L, Cunningham RM, Young JS, Fry CH, McMurray G, Eccles R, McCloskey KD (2012). Altered distribution of interstitial cells and innervation in the rat urinary bladder following spinal cord injury. Journal of Cellular and Molecular Medicine. 6: 1533-1543.

Fry CH, Sadananda P, Wood DN, Thiruchelvam N, Jabr RI, Claydon R. (2011) Modelling the urinary tract - computational, physical and biological methods Neurourology and Urodynamics. 30: 692-629.

Wyndaele JJ, Gammie A, Abrams P, Bruschini H, De Wachter S, Fry CH, Jabr RI, Kirschner-Hermanns R, Madersbacher H. (2011). Bladder compliance what does it represent. Can we measure it, and is it clinically relevant? Neurourology and Urodynamics; 30: 714-722

Levy BF, Scott MJ, Fawcett W, Fry CH, Rockall TA (2011). Randomised controlled trial to assess the optimal analgesic regime for patients undergoing laparoscopic colorectal surgery. British Journal of Surgery; 98:1068-1078.

Wu C, Sui GP, Fry CH (2011). Intracellular Ca2+ regulation and electrophysiolgical properties of bladder urothelium subjected to stretch and exogenous agonists. Cell Calcium, 49: 395-399.

Fry CH, Bayliss M, Young JS, Hussain M (2011) Influence of age and bladder dysfunction on the contractile properties of isolated human detrusor smooth muscle. BJU International; 108: E91-96.

Fry CH, Wood DN (2010). The physiological properties of the lower urinary tract. In The Scientific Basis of Urology, ed Mundy AR, Fitzpatrick M, Neal DE, George NJ. 3rd edition, Informa Healthcare

Fry CH, Young JS. (2010). The physiology and pharmacology of the lower urinary tract. Surgery; 28: 317-322.

Fry CH, Daneshgari F, Thor K, Drake M, Eccles R, Kanai AJ, Birder LA (2010). Animal models and their use in understanding lower urinary tract dysfunction. Neurourology and Urodynamics; 29: 603-608.

Birder LA, Kanai AJ, Cruz F, Moore K, Fry CH (2010). Is the urothelium intelligent? Neurourology and Urodynamics; 29: 598-602.

Abrams P, Andersson KE, Birder L, Brubaker L, Cardozo L, Chapple C, Cottenden A, Davila W, de Ridder D, Dmochowski R, Drake M, Dubeau C, Fry C, Hanno P, Smith JH, Herschorn S, Hosker G, Kelleher C, Koelbl H, Khoury S, Madoff R, Milsom I, Moore K, Newman D, Nitti V, Norton C, Nygaard I, Payne C, Smith A, Staskin D, Tekgul S, Thuroff J, Tubaro A, Vodusek D, Wein A, Wyndaele JJ (2010). Fourth International Consultation on Incontinence Recommendations of the International Scientific Committee: Evaluation and treatment of urinary incontinence, pelvic organ prolapse, and fecal incontinence. Neurourology and Urodynamics; 29: 213-240.

Fry CH, Meng E, Young JS (2010). The physiological function of lower urinary tract smooth muscle. Autonomic Neuroscience; 154: 3-13.

Roosen A, Blake-James BT, Wood D, Fry CH (2009). Clinical and experimental aspects of Adreno-muscarinic synergy in the bladder base and prostate. Neurourology and Urodynamics;28 :938-943.

Williamson TH, Grewal J, Gupta B, Mokete B, Lim M, Fry CH (2009) Measurement of PO2 during vitrectomy for central retinal vein occlusion, a pilot study. Graefes Arch Clin Exp Ophthalmol; 247: 1019-1023.

Sui G, Fry CH, Malone-Lee J, Wu C (2009). Aberrant Ca2+ oscillations in smooth muscle cells from overactive human bladders. Cell Calcium. 45: 456-464.

Roosen A, Datta SN, Chowdhury RA, Patel PM, Kalsi V, Elneil S, Dasgupta P, Kessler TM, Khan S, Panicker J, Fry CH, Brandner S, Fowler CJ, Apostolidis A (2009). Suburothelial myofibroblasts in the human overactive bladder and the effect of botulinum neurotoxin type A treatment. European Urology 2009; 55: 1440-1448.

Roosen A, Fry CH (2009). TGF-beta1 Inhibits Cx43 expression and formation of functional syncytia in cultured smooth muscle cells from human detrusor. European Urology; 55: 497-498.

Roosen A, Fry CH, Sui G, Wu C (2009). Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms. Cell Calcium; 45: 11-17.

Roosen A, Wu C, Sui G, Chowdhury RA, Patel PM, Fry CH (2009). Characteristics of spontaneous activity in the bladder trigone. European Urology. 2009; 56: 346-353.