Dr. Jose Jimenez is a molecular microbiologist that earned his Ph.D. in 2006 working for Spanish Research Council (CIB-CSIC) in environmental bacteria for the removal of pollutants. After that he moved into systems and synthetic biology of bacteria in a postdoctoral stay in the National Center for Biotechnology (CSIC; Spain) where he developed molecular tools for engineering metabolic pathways.
In 2010 he joined the Center for Systems Biology at Harvard University (USA) as a Fellow for the Foundational Questions in Evolutionary Biology program to study evolutionary dynamics of microbial and prebiotic systems. In 2012 he enrolled in the Synthetic Biology Center at MIT (USA) as a postdoctoral associate where he studied mechanisms of cellular competition for gene expression in bacteria.
Dr. Jimenez has lead the SynBio lab at Surrey since 2014. His research is currently sponsored by BBSRC and the programme Horizon2020 of the European Union.
The principles guiding engineering efforts in Synthetic Biology can be very well summarized by Richard Feynman's quote 'What I cannot create, I do not understand'. However, many times unexpected emergent behaviors arise in living cells and we can't just ignore them. This is particularly bad when trying to implement genetic circuits to carry out a specific function.
The synbio lab at Surrey focuses on that problem. We are looking into the economics of cellular resources in bacteria; if we understand how cells decide to allocate their resources, we will be able to efficiently design genetic circuits capable of performing many different tasks. We also try to take advantage of evolution using combinatorial approaches for tailored functions. We are interested in everything that evolves with special mention to ribozymes, bacteriophages and antibodies.
Dr. Irene Chen (University of California Santa Barbara, USA)
Dr. Domitilla Del Vecchio (Massachusetts Institute of Technology, USA)
Prof. Victor de Lorenzo (National Center for Biotechnology-CSIC, Spain).
Prof. Declan Bates (University of Warwick, UK).
BMS1047 Molecular Biology - Genes and their Function
BMS2044 Microbial Communities and InteractionsBMS3092 Advanced Technologies in Gene Expression
MMIM018 Pathogenesis of Infectious DiseasesMMIM024 Bacterial genetics and Molecular BiologyMMIM029 Journal Club
MMVM002 Microbial Genetics
Dr. Manuel Salvador de Lara (email)
Dr. Juhyun Kim (email)
P4SB: From plastic waste to plastic value using Pseudomonas putida synthetic biology. Horizon2020. European Commission (2015-2019).
The role of the cellular economics in the expression of exogenous genes: Towards modularity in synthetic circuit design. BBSRC (2015-2018).
<p>Book chapters</p><p>de Lorenzo V., Fraile S. and Jimenez J.I. Emerging Systems and Synthetic Biology approaches to Hydrocarbon Biotechnology. (2009) In Handbook of Hydrocarbon and Lipid Microbiology. Chapter 41, 1411-1435 Ed.: K. Timmis, Springer Publishers.</p><p>Jimenez J.I., Nogales J., García J.L. and Diaz E. A genomic view of the catabolism of aromatic compounds in Pseudomonas. (2009) In Handbook of Hydrocarbon and Lipid Microbiology. Chapter 35, 1297-1325 Ed.: K. Timmis, Springer Berlin Heidelberg Publishers.</p><p>Jimenez J.I., Minambres B., Garcia J.L. and Diaz E. Genomic insights in the metabolism of aromatic compounds in Pseudomonas putida KT2440. (2004) In Pseudomonas. Vol. 3, chapter 15, 425-462 Ed. J.L. Ramos. Kluwer Publishers.</p>