Professor Paul A. Townsend
About
Biography
Professor Paul Townsend is Pro-Vice-Chancellor and Executive Dean for the Faculty of Health and Medical Sciences. An internationally renowned scientist in the field of cell stress and survival mechanisms, Paul has a passion for teaching and mentoring both undergraduate and postgraduate students. He brings with him a wealth of industry and enterprise experience, having co-founded several companies and provided strategic advice to others in the sector. He is adjunct professor at A*STAR, Singapore, as well as Honorary Research Professor at the University of Athens.
Paul is a University of York graduate (1993) and obtained his PhD from the Imperial Cancer Research Fund (now CRUK) in 1997. He has researched cell survival mechanisms in a number of chronic diseases. He has undertaken research in Germany and the USA as well as the UK and became an academic independent group leader at the University of Southampton (2004-2013). He joined the University of Manchester in 2013 as the Associate Dean for Business Engagement Research professor in the Manchester Cancer Research Centre/ CRUK Manchester Institute.
Previously, he helped establish a graduate entry to Medicine UG programme and a number of Masters’ courses, in addition to successful research funding to large scale infrastructure of £12.8M Stoller from the MRC as Co-I, and £28.5M BRC from NIHR as Co-I. He presents frequently at UK and international conferences as well as contributing to UKRI committees, international agencies such as WeHi and Peter Mac in Australia, NIH in the US, Hong Kong, Pasteur Institute in France, HRB in Ireland and co-chairs the Clinical and Sciences Committee of the FCT in Portugal.
He has research strengths in drug discovery, validation, cell stress and survival mechanisms, senescence, DNA damage, and the use of AI and multiple ‘omics in cancer, bone cell and cardiac biology, and apoptosis regulation. Recently, he has explored senescence and licensed the technology he invented along with using advanced mass spectrometry in identifying novel biomarkers and regulators of cellular homeostasis. Paul is also the cofounder of Karus Therapeutics now based in Oxford, raised >$120M, Pentagon Therapeutics and PRECignature whilst also advising a number of other companies as a consultant and Non-Executive Director.
Overall, Paul’s academic-enterprising health and wellness research, linking to social and engineering sciences, knowledge exchange and partnership generation acumen and experience is internationally recognised; he conducts teaching and research to a consistently high level, generating significant levels of funding and outputs, is passionate about his UG/PG teaching and mentorship and interacts exceptionally with all stakeholders including industry - generating IP, guiding colleagues and students in their research, teaching and enterprise activities, as well as working intimately with the NHS, NIHR, NHS England and the community via many outreach activities.
News
Publications
2021
Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis SM Soond, LV Savvateeva, VA Makarov, NV Gorokhovets, PA Townsend, ...Pharmaceutics 13 (3), 339
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations MP Huynh-Le, CC Fan, R Karunamuni, WK Thompson, ME Martinez, ... Nature communications 12 (1), 1-9
High-Throughput Microbore Ultrahigh-Performance Liquid Chromatography-Ion Mobility-Enabled-Mass Spectrometry-Based Proteomics Methodology for the Exploratory Analysis of Serum …S Lennon, CJ Hughes, A Muazzam, PA Townsend, LA Gethings, ...Journal of Proteome Research
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer RA Karunamuni, MP Huynh-Le, CC Fan, W Thompson, RA Eeles, ...Prostate cancer and prostatic diseases, 1-10
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction DV Conti, BF Darst, LC Moss, EJ Saunders, X Sheng, A Chou, ...Nature genetics 53 (1), 65-75
Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis SM Soond, LV Savvateeva, VA Makarov, NV Gorokhovets, PA Townsend, ...Cancers 12 (11), 3476
2020
Integrative p53, micro-RNA and Cathepsin Protease Co-Regulatory Expression Networks in Cancer SM Soond, MV Kozhevnikova, PA Townsend, AA Zamyatnin... Cancers 12 (11), 3454
The CHEK2 Variant C. 349A> G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor A Brandão, P Paulo, S Maia, M Pinheiro, A Peixoto, M Cardoso, MP Silva, ...Cancers 12 (11), 3254
Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation N Lim, PA Townsend International journal of cancer 147 (6), 1528-1534
Investigation of the chondrocyte response to varying mechanical load: assessment of impact stress SM Higgins, RC Jones, KM Lawrence, SM Richardson, PA Townsend... Osteoarthritis and Cartilage 28, S179
Additional SNPs improve the performance of a polygenic hazard score for prostate cancer R Karunamuni, MP Huynh-Le, CC Fan, W Thompson, R Eeles, ...medRxiv
Stuwe, W, Emmott, E., Bailey, M. et al., and the MS The COVID-19 MS Coalition (incl: Townsend, P.A.), Barran, P. The COVID-19 MS Coalition – accelertating diagnostics, prognostics, and treatment. Lancet, 2020, 395 (10239):P1761-2. DOI: 10.1016/S0140-6736(20)31211-3
Lim, N., and Townsend, P.A. Cdc6 as a novel target in cancer: oncogenic potential, senescence and subcellular localisation. Int. J. Cancer, 2020, In Press. PMID32010971
Hollis B, Day FR, Busch AS, Thompson DJ, Soares ALG, Timmers PRHJ, Kwong A, Easton DF, Joshi PK, Timpson NJ; PRACTICAL Consortium (incl: Townsend, P.A.); 23andMe Research Team, Ong KK, Perry JRB. Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and life span. Nat Commun. 2020, 11(1):1536. DOI:10.1038/s41467-020-14451-5
2019
Sakellaropoulos T., Vougas K., Narang S., Koinis F., Kotsinas A., Polyzos A., Moss T.J., Piha-Paul S., Zhou H., Kardala E., Damianidou E., Alexopoulos L.G., Aifantis I., Townsend P.A., Panayiotidis M.I., Sfikakis P., Bartek J., Fitzgerald R.C., Thanos D., Mills-Shaw K.R., Petty R., Tsirigos A., Gorgoulis V.G. A deep learning framework for prediciting response to therapy in cancer. Cell Rep. 2019, 29(11):3367-3373. PMID31825821
The Senescence Consortium. Cellular senescence: defining a path porward. Cell, 2019, 179(4):813-827. PMID31675495
Vougas K., Sakellaropoulos T., Kotsinas A., Foukas G.P., Ntargaras A., Koinis F., Polyzos A., Myrianthopoulos V., Zhou H., Narang S., Georgoulias V., Alexopoulos L., Aifantis I., Townsend P.A., Sfikakis P., Fitzgerald R., Thanos D., Bartek J., Petty R., Tsirigos A., Gorgoulis V.G. Machine learning and data mining frameworks for predicitng drug responses in cancer: an overview and a novel in silico screening process based on association rule mining. Pharamcol. Ther. 2019 Jul 30:107395. doi: 10.1016/j.pharmthera.2019.107395. PMID31374225
Mavropoulos, E., Mallios, D., Agrogiannis, G., Pateras, I., Evangelou, K., Joseph, L., Howe, M.C., Chaturvedi, A., Rogan, J., Townsend, P.A., Gorgoulis, V.G., Vpigas, K. Breast Cancer pN Staging with Deep Learning. 2019. From: Researchgate, DOI:10.13140/RG.2.2.33459.58405
Soond, S.M., Kozhevnikova, M.V., Frolova, A.S., Savvateeva, L.V., Plotnikov, E.Y., Townsend, P.A., Han, Y.P., Zamyatnin, A.A. Jr. Lost or forgotten: the nuclear cathepsin protein isofirms in cancer. Cancer Lett., 2019, 462:43-50. https://doi.org/10.1016/j.canlet.2019.07.020
Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., ... Townsend, P. A. … Lindström, S. (2019). Shared heritability and functional enrichment across six solid cancers. Nature Communications, 10(1), 431. https://doi.org/10.1038/s41467-018-08054-4
Loveday, C., Sud A., … Townsend, P.A., et al., UK Testicular Cancer Collaboration; PRACTICAL Consortium, Reid, A., Huddart, R.A., Houlston, R.S., Turnbull, C. Runs of homozygosity and testicular cancer risk. Andrology. 2019 Jul;7(4):555-564. https://doi.org/10.1111/andr.12667
Soond, S.M., Kozhevnikova, M.V., Townsend, P.A., Zamyatnin, A.A. Jr. Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer. Pharmaceuticals (Basel). 2019. PMCID: PMC6630828
Law, P.J., Timofeeva, M., … Townsend, P.A. et al., PRACTICAL consortium, … Tomlinson, I., Houlston, R.S., Dunlop, M.G., Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nat Commun. 2019 10(1):2154. https://doi.org/10.1038/s41467-019-09775-w
PRACTICAL Consortium & Townsend, P. A. et al., (2019). Germline variation at 8q24 and prostate cancer risk in men of European ancestry. Nature Communications, 10(1), 382. https://doi.org/10.1038/s41467-019-08293-z
PRACTICAL Consortium, & Townsend, P. A. et al (2019). Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. Nature Communications, 10(1), 213. https://doi.org/10.1038/s41467-018-08107-8
Schumacher, F. R., Olama, A. A. A., Berndt, S. I., Benlloch, S., Ahmed, M., Saunders, E. J., ... Townsend, P. A. et al (2019). Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nature Genetics. https://doi.org/10.1038/s41588-018-0330-6
PRACTICAL Consortium (2019). Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 28(1), 208-216. https://doi.org/10.1158/1055-9965.EPI-18-0079
Rizou, S. V., Evangelou, K., Myrianthopoulos, V., Mourouzis, I., Havaki, S., Athanasiou, A., ... Gorgoulis, V. G. (2019). Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids. In Methods in Molecular Biology (Vol. 1896, pp. C1-C2). (Methods in Molecular Biology (Clifton, N.J.)). https://doi.org/10.1007/978-1-4939-8931-7_19
Harrison, O. J., Torrens, C., Salhiyyah, K., Modi, A., Moorjani, N., Townsend, P. A., ... Cagampang, F. (2019). Defective NOTCH signalling drives smooth muscle cell death and differentiation in bicuspid aortic valve aortopathy. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. https://doi.org/10.1093/ejcts/ezy464
2018
Taylor, S., Simões-Sousa, S., Littler, S., Thompson, S., Minshall, P., Whalley, H., ... Townsend, P. et al. (2018). The p38α stress kinase suppresses aneuploidy tolerance by inhibiting Hif-1α. Cell Reports, 25(3). https://doi.org/10.1016/j.celrep.2018.09.060
Banerjee, A., Arvinrad, P., Darley, M., Laversin, S. A., Parker, R., Rose-Zerilli, M. J. J., ... Blaydes, J. P. (2018). The effects of restricted glycolysis on stem-cell like characteristics of breast cancer cells. Oncotarget, 9(33), 23274-23288. https://doi.org/10.18632/oncotarget.25299
Muazzam, A., Whetton, A., & Townsend, P. A. (2018). Can Rhus Coriaria be a Potential, Natural, Treatment for Prostate Cancer? Cancer Science and Oncology, 2(1), 13-18.
Harrison, O. J., Cagampang, F., Ohri, S. K., Torrens, C., Salhiyyah, K., Modi, A., ... Townsend, P. A. (2018). Candidate plasma biomarkers for predicting ascending aortic aneurysm in bicuspid aortic valve disease. Journal of Cardiothoracic Surgery, 13(1). https://doi.org/10.1186/s13019-018-0762-1
Muir, K., Lophatananon, A., West, C., Elliott, R., Townsend, P. A., & et al., (2018). Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nature Communications, 9, [2256]. https://doi.org/10.1038/s41467-018-04109-8
Zeidan, B., Manousopoulou, A., Garay-Baquero, D. J., White, C. H., Larkin, S. E. T., Potter, K. N., ... Garbis, S. D. (2018). Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study. Breast Cancer Research, 20(1), 19. https://doi.org/10.1186/s13058-018-0938-6, https://doi.org/10.1186/s13058-018-0938-6
The PRACTICAL Consortium (2018). Large-scale transcriptome-wide association study identifies new prostate cancer risk regions. Nature Communications, 9(1), [4079]. https://doi.org/10.1038/s41467-018-06302-1
Larkin, S. E. T., Abbott, B., Brown, M. D., Jackson, T. R., Clarke, N. W., & Townsend, P. A. (2018). Proteomics in Prostate Cancer Research. In B. D. Robinson, J. M. Mosquera, J. Y. Ro, & M. Divatia (Eds.), Precision Molecular Pathology of Prostate Cancer (pp. 213-236). Cham: Springer International Publishing AG. https://doi.org/10.1007/978-3-319-64096-9_14
2017
Petrakis, T. G., Komseli, E-S., Papaioannou, M., Vougas, K., Polyzos, A., Myrianthopoulos, V., ... Gorgoulis, V. G. (2017). Erratum to 'Exploring and exploiting the systemic effects of deregulated replication licensing' [Seminars in Cancer Biology 37-38C, (2016) 3-15]. Seminars in Cancer Biology, 43, 180. https://doi.org/10.1016/j.semcancer.2017.02.002
Johnston, H. E., Carter, M. J., Cox, K. L., Dunscombe, M., Manousopoulou, A., Townsend, P. A., ... Cragg, M. S. (2017). Integrated cellular and plasma proteomics of contrasting B-cell cancers reveals common, unique and systemic signatures. Molecular and Cellular Proteomics, 16(3), 386-406. https://doi.org/10.1074/mcp.M116.063511
Owens, G., Lawrence, K., Jackson, T., Crosbie, E., Sayan, B., Kitchener, H., & Townsend, P. A. (2017). Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen. Cancer Medicine, 6(2), 408-415. https://doi.org/10.1002/cam4.967
Evangelou, K., Lougiakis, N., Rizou, S. V., Kotsinas , A., Kletsas, D., Espín, D. M., ... Gorgoulis, V. (2017). Robust, universal biomarker assay to detect senescent cells in biological specimens. Aging Cell, 16(1), 192-197. https://doi.org/10.1111/acel.12545
Lawrence, K., Jones, R., Jackson, T., Baylie, R., Abbott, B., Bruhn-Olszewska, B., ... Townsend, P. (2017). Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1. Scientific Reports, 7, [5147]. https://doi.org/10.1038/s41598-017-04367-4
Sud, A., Thomsen, H., Law, P. J., Försti, A., Filho, M. I. D. S., Holroyd, A., ... Houlston, R. S. (2017). Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nature Communications, 8(1), [1892]. https://doi.org/10.1038/s41467-017-00320-1
2016
Larkin, S., Johnston, H., Jackson, T., Jamieson, D., Roumeliotis, T., Mockridge, C., ... Townsend, P. A. (2016). Detection of candidate biomarkers of prostate cancer progression in serum; a depletion-free 3D LC/MS quantitative proteomics pilot study. British Journal of Cancer, 115(9), 1078-1086. https://doi.org/10.1038/bjc.2016.291
Greenhough, J., Papadakis, E. S., Cutress, R. I., Townsend, P. A., Oreffo, R. O. C., & Tare, R. S. (2016). Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1). Scientific Reports, 6, 33504. https://doi.org/10.1038/srep33504
Galanos, P., Vougas, K., Walter, D., Polyzos, A., Haagensen, E. J., Kokkalis, A., ... Gorgoulis, V. G. (2016). Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nature Cell Biology, 18(7), 777-789. https://doi.org/10.1038/ncb3378
Georgakopoulou, E., Evangelou, K., Havaki, S., Townsend, P., Kanavaros, P., & Gorgoulis, V. (2016). Apoptosis or Senescence? Which exit route do epithelial cells and fibroblasts preferentially follow? Mechanisms of Ageing and Development. https://doi.org/10.1016/j.mad.2016.03.010
Vougas, K., Jackson, T., Polyzos, A., Liontos, M., Elizabeth, O., Georgoulias, V., ... Gorgoulis, V. G. (2016). Deep Learning and Association Rule Mining for Predicting Drug Response in Cancer: A Personalised Medicine Approach. In bioRxiv (bioRxiv). https://doi.org/10.1101/070490
2015
Petrakis, T. G., Komseli, E-S., Papaioannou, M., Vougas, K., Polyzos, A., Myrianthopoulos, V., ... Gorgoulis, V. G. (2015). Exploring and exploiting the systemic effects of deregulated replication licensing. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2015.12.002
Zeidan, B. A., Townsend, P. A., Garbis, S. D., Copson, E., & Cutress, R. I. (2015). Clinical proteomics and breast cancer. The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 13(5). https://doi.org/10.1016/j.surge.2014.12.003
Pateras, I. S., Havaki, S., Nikitopoulou, X., Vougas, K., Townsend, P. A., Panayiotidis, M. I., ... Gorgoulis, V. G. (2015). The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where. Pharmacology & therapeutics, 154. https://doi.org/10.1016/j.pharmthera.2015.06.011
Zeidan, B., Jackson, T. R., Larkin, S. E. T., Cutress, R. I., Coulton, G. R., Ashton-Key, M., ... Townsend, P. A. (2015). Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target. Oncotarget, 6(25). https://doi.org/10.18632/oncotarget.4070
Lawrence, KM., Jackson, TR., Richardson, SM., & Townsend, P.A.. (2015). The Urocortin System: A Novel Bone Regulatory Triad, Working In Opposition to RANKL/RANK/OPG. Journal of Osteoporosis & Physical Activity, 2015.
Zhang, Z., Liu, R., Townsend, P. A., & Proud, C. G. (2015). Corrigendum to “p90RSKs mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes”[J Mol Cell Cardiol 59 (2013) 139–147]. Journal of molecular and cellular cardiology. https://doi.org/10.1016/j.yjmcc.2015.05.001
Lamb, R., Harrison, H., Smith, D., Townsend, P. A., Jackson, T., Ozsvari, B., ... Sotgia, F. (2015). Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction. Oncotarget, 6(7), 4585-4601. https://doi.org/10.18632/oncotarget.3278
Lawrence, K. M., Jackson, T. R., Jamieson, D., Stevens, A., Owens, G., Sayan, BS., ... Townsend, P. A. (2015). Urocortin--from Parkinson's disease to the skeleton. The International Journal of Biochemistry & Cell Biology, 60, 130-138. https://doi.org/10.1016/j.biocel.2014.12.005
Georgiadis, V., Stephanou, A., Townsend, P. A., & Jackson, T. R. (2015). MultiElec: A MATLAB Based Application for MEA Data Analysis. PLoS ONE, 10(6). https://doi.org/10.1371/journal.pone.0129389
Huna, A., Salmina, K., Erenpreisa, J., Vazquez-Martin, A., Krigerts, J., Inashkina, I., ... Jackson, T. R. (2015). Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle (Georgetown, Tex.), 14(18). https://doi.org/10.1080/15384101.2015.1056948
2014
Georgakilas, A. G., Tsantoulis, P., Kotsinas, A., Michalopoulos, I., Townsend, P., & Gorgoulis, V. G. (2014). Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress? Cellular and Molecular Life Sciences : CMLS, 71(23). https://doi.org/10.1007/s00018-014-1717-x
Al-Daghri, N. M., Al-Attas, O. S., Johnston, H. E., Singhania, A., Alokail, M. S., Alkharfy, K. M., ... Garbis, S. D. (2014). Whole serum 3D LC-nESI-FTMS quantitative proteomics reveals sexual dimorphism in the milieu intérieur of overweight and obese adults. Journal of Proteome Research, 13(11). https://doi.org/10.1021/pr5003406
Kotsinas, A., Papanagnou, P., Galanos, P., Schramek, D., Townsend, P., Penninger, J. M., ... Gorgoulis, V. G. (2014). MKK7 and ARF: new players in the DNA damage response scenery. Cell Cycle (Georgetown, Tex.), 13(8). https://doi.org/10.4161/cc.28654
Zeidan, B., Jackson, T., Larkin, S., Cutress, R., Ashton-Key, M., Packham, G., ... Townsend, P. (2014). 225. Annexin A3 is a breast cancer marker secreted by neoplastic cell lines and is involved in cell migration. European Journal of Surgical Oncology, 40(11). https://doi.org/10.1016/j.ejso.2014.08.219
Townsend, P., Zeidan, B. A., Jackson, T., Larkin, S. ET., Cutress, R. I., Coulton, G. R., ... Garbis, S. D. (2014). Annexin A3 is a breast cancer marker secreted by neoplastic cell lines and involved in cell migration. In anticancer Research (Vol. 34, pp. 6216-6216)
Kotsinas, A., Papanagnou, P., Evangelou, K., Trigas, G. C., Kostourou, V., Townsend, P., & Gorgoulis, V. G. (2014). ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis. Frontiers in Genetics, 5. https://doi.org/10.3389/fgene.2014.00236
2013
Skeen, V. R., Collard, T. J., Southern, S. L., Greenhough, A., Hague, A., Townsend, P. A., ... Williams, A. C. (2013). BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells. Oncogene, 32(38), 4490-4499. https://doi.org/10.1038/onc.2012.480
Garbis, S. D., & Townsend, P. A. (2013). Proteomics of human prostate cancer biospecimens: the global, systems-wide perspective for protein markers with potential clinical utility. Expert Review of Proteomics, 10(4). https://doi.org/10.1586/14789450.2013.827408
Miranda, E., Nordgren, I. K., Male, A. L., Lawrence, C. E., Hoakwie, F., Cuda, F., ... Tavassoli, A. (2013). A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. Journal of the American Chemical Society, 135(28), 10418-10425. https://doi.org/10.1021/ja402993u
Intekhab-Alam, N. Y., White, O. B., Getting, S. J., Petsa, A., Knight, R. A., Chowdrey, H. S., ... Locke, I. C. (2013). Urocortin protects chondrocytes from NO-induced apoptosis: A future therapy for osteoarthritis? Cell Death and Disease, 4(7), [e717]. https://doi.org/10.1038/cddis.2013.231
Ankrett, D. N., Carugo, D., Lei, J., Glynne-Jones, P., Townsend, P. A., Zhang, X., & Hill, M. (2013). The effect of ultrasound-related stimuli on cell viability in microfluidic channels. Journal of Nanobiotechnology, 11(1), [20]. https://doi.org/10.1186/1477-3155-11-20
Zhang, Z., Liu, R., Townsend, P. A., & Proud, C. G. (2013). P90RSKs mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes. Journal of Molecular and Cellular Cardiology, 59, 139-147. https://doi.org/10.1016/j.yjmcc.2013.03.006
Papachristou, E. K., Roumeliotis, T. I., Chrysagi, A., Trigoni, C., Charvalos, E., Townsend, P. A., ... Garbis, S. D. (2013). The shotgun proteomic study of the human ThinPrep cervical smear using iTRAQ mass-tagging and 2D LC-FT-Orbitrap-MS: The detection of the human papillomavirus at the protein level. Journal of Proteome Research, 12(5), 2078-2089. https://doi.org/10.1021/pr301067r
Roumeliotis, T. I., Halabalaki, M., Alexi, X., Ankrett, D., Giannopoulou, E. G., Skaltsounis, A. L., ... Garbis, S. D. (2013). Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level. Journal of Proteome Research, 12(4), 1591-1603. https://doi.org/10.1021/pr300968q
Jackson, T. R., Salmina, K., Huna, A., Inashkina, I., Jankevics, E., Riekstina, U., ... Erenpreisa, J. (2013). DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells. Cell Cycle, 12(3), 430-441. https://doi.org/10.4161/cc.23285
Hewitson, R., Dargan, J., Collis, D., Green, A., Moorjani, N., Ohri, S., & Townsend, P. A. (2013). Heart failure: The pivotal role of histone deacetylases. International Journal of Biochemistry and Cell Biology, 45(2), 448-453. https://doi.org/10.1016/j.biocel.2012.11.006
Rosengarten, JA., Scott, PA., Larkin, SE., Garbis, S., Curzen, NP., Townsend, P.A.., & Morgan, JM. (2013). 070 High resolution multidimensional proteomics detects candidate arrhythmia biomarkers. Heart, 99(suppl 2), A45-A46.
Edwards, H., Dargan, J., Elliot, L., Modi, A., Ohri, S., & Townsend, P. (2013). Apoptosis in the media of the aortic wall and its relationship with aortic valve morphology in aortic dilatation. Artery Research, 7(3), 136-136.
Rosengarten, JA., Scott, PA., Larkin, SE., Garbis, S., Curzen, NP., Townsend, P.A.., ... Wang, XL. (2013). Main Session: Molecular mechanisms in cardiomyopathies. Europace, 15(suppl 2), ii11-ii11.
Erenpreisa, J., Jackson, TR., Huna, A., Salmina, K., Innashkina, I., Jankevics, E., ... Cragg, MS. (2013). P05. 04 Cooperation of senescence with self-renewal in pa1 embryonal carcinoma cells treated with etoposide. Annals of Oncology, 24(suppl 1), i30-i31.
Carroll, C. J., Sayan, B. S., Bailey, S. G., McCormick, J., Stephanou, A., Latchman, D. S., & Townsend, P. A. (2013). Regulation of myocardial interleukin-6 expression by p53 and STAT1. Journal of Interferon & Cytokine Research, 33(9), 542-548. https://doi.org/10.1089/jir.2012.0165
2012
Scott, P. A., Zeidan, B., Ng, L. L., Zeb, M., Rosengarten, J. A., Garbis, S., ... Townsend, P. A. (2012). Proteomic profiling to identify prognostic biomarkers in heart failure. In Vivo, 26(6), 875-882.
Collard, T. J., Urban, B. C., Patsos, H. A., Hague, A., Townsend, P. A., Paraskeva, C., & Williams, A. C. (2012). The retinoblastoma protein (Rb) as an anti-apoptotic factor: Expression of Rb is required for the antiapoptotic function of BAG-1 protein in colorectal tumour cells. Cell Death and Disease, 3(10), [e408]. https://doi.org/10.1038/cddis.2012.142
Larkin, S. E. T., & Townsend, P. A. (2012). Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population. BJU international, 110(6B), E326. https://doi.org/10.1111/j.1464-410X.2012.11236.x
Southern, S. L., Collard, T. J., Urban, B. C., Skeen, V. R., Smartt, H. J., Hague, A., ... Williams, A. C. (2012). BAG-1 interacts with the p50-p50 homodimeric NF-B complex: Implications for colorectal carcinogenesis. Oncogene, 31(22), 2761-2772. https://doi.org/10.1038/onc.2011.452
Gaspar-Pereira, S., Fullard, N., Townsend, P. A., Banks, P. S., Ellis, E. L., Fox, C., ... Oakley, F. (2012). The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis. American Journal of Pathology, 180(3), 929-939. https://doi.org/10.1016/j.ajpath.2011.11.007
Larkin, S. E. T., Holmes, S., Cree, I. A., Walker, T., Basketter, V., Bickers, B., ... Aukim-Hastie, C. (2012). Identification of markers of prostate cancer progression using candidate gene expression. British Journal of Cancer, 106(1), 157-165. https://doi.org/10.1038/bjc.2011.490
Bailey, SG., Cragg, MS., & Townsend, P.A.. (2012). Role of STAT-1 in the breast. JAK-STAT, 1(3), 197-199.
Townsend, P.A.., Garbis, SD., & Khan, TK. (Ed.) (2012). The discovery of cancer tissue specific proteins in serum: Case studies on prostate cancer. In Biomarker (pp. 333-360). INTECH. https://doi.org/10.5772/2376
2011
Carugo, D., Ankrett, D. N., Glynne-Jones, P., Capretto, L., Boltryk, R. J., Zhang, X., ... Hill, M. (2011). Contrast agent-free sonoporation: The use of an ultrasonic standing wave microfluidic system for the delivery of pharmaceutical agents. Biomicrofluidics, 5(4), [044108]. https://doi.org/10.1063/1.3660352
Scott, P. A., Townsend, P. A., Ng, L. L., Zeb, M., Harris, S., Roderick, P. J., ... Morgan, J. M. (2011). Defining potential to benefit from implantable cardioverter defibrillator therapy: The role of biomarkers. Europace, 13(10), 1419-1427. https://doi.org/10.1093/europace/eur147
Slater-Jefferies, J. L., Lillycrop, K. A., Townsend, P. A., Torrens, C., Hoile, S. P., Hanson, M. A., & Burdge, G. C. (2011). Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor- in the heart of the offspring. Journal of Developmental Origins of Health and Disease, 2(4), 250-255. https://doi.org/10.1017/S2040174410000425
Bailey, S. G., Cragg, M. S., & Townsend, P. A. (2011). Family friction as Δnp73 antagonises p73 and p53. International Journal of Biochemistry and Cell Biology, 43(4), 482-486. https://doi.org/10.1016/j.biocel.2010.12.022
Tiffon, C. E., Adams, J. E., Van Der Fits, L., Wen, S., Townsend, P. A., Ganesan, A., ... Packham, G. (2011). The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells. British Journal of Pharmacology, 162(7), 1590-1602. https://doi.org/10.1111/j.1476-5381.2010.01188.x
Carroll, C. J., Suleman, N., Davidson, S. M., Faulkes, D. J., Diss, J. K., Knight, R., ... Townsend, P. A. (2011). Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injury. International Journal of Biochemistry and Cell Biology, 43(1), 74-79. https://doi.org/10.1016/j.biocel.2010.09.020
Shuttleworth, S., Townsend, P., Silva, F., Cecil, A., Hill, T., Tomassi, C., ... Harrison, R. (2011). Progress in the development of small molecule therapeutics targeting Th17 cell function for the treatment of immune-inflammatory diseases. In Progress in Medicinal Chemistry|Prog. Med. Chem. (50 ed., Vol. 50, pp. 109-133). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-381290-2.00003-3
2010
Barry, S. P., Townsend, P. A., Knight, R. A., Scarabelli, T. M., Latchman, D. S., & Stephanou, A. (2010). STAT3 modulates the DNA damage response pathway. International Journal of Experimental Pathology, 91(6), 506-514. https://doi.org/10.1111/j.1365-2613.2010.00734.x
Slater-Jefferies, J. L., Hoile, S. P., Lillycrop, K. A., Townsend, P. A., Hanson, M. A., & Burdge, G. C. (2010). Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Prostaglandins, Leukotrienes & Essential Fatty Acids, 83(4-6), 219-223. https://doi.org/10.1016/j.plefa.2010.07.006
Barry, S. P., Lawrence, K. M., McCormick, J., Soond, S. M., Hubank, M., Eaton, S., ... Stephanou, A. (2010). New targets of urocortin-mediated cardioprotection. Journal of Molecular Endocrinology, 45(2), 69-85. https://doi.org/10.1677/JME-09-0148
Lambrianides, A., Carroll, C. J., Pierangeli, S. S., Pericleous, C., Branch, W., Rice, J., ... Giles, I. P. (2010). Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways. Journal of Immunology, 184(12), 6622-6628. https://doi.org/10.4049/jimmunol.090276
Bailey, S. G., Sanchez-Elsner, T., Stephanou, A., Cragg, M. S., & Townsend, P. A. (2010). Regulating the genome surveillance system: MiRNAs and the p53 super family. Apoptosis, 15(5), 541-552. https://doi.org/10.1007/s10495-010-0456-1
Al-Ruwaili, J. A., Larkin, S. E. T., Zeidan, B. A., Taylor, M. G., Adra, C. N., Aukim-Hastie, C. L., & Townsend, P. A. (2010). Discovery of serum protein biomarkers for prostate cancer progression by proteomic analysis. Cancer Genomics and Proteomics, 7(2), 93-103.
Larkin, S. E., Zeidan, B., Taylor, M. G., Bickers, B., Al-Ruwaili, J., Aukim-Hastie, C., & Townsend, P. A. (2010). Proteomics in prostate cancer biomarker discovery. Expert Review of Proteomics, 7(1), 93-102. https://doi.org/10.1586/epr.09.89
Souslova, V., Townsend, P. A., Mann, J., van der Loos, C. M., Motterle, A., D'Acquisto, F., ... Ye, S. (2010). Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFκB. PLoS ONE, 5(3), [e9902]. https://doi.org/10.1371/journal.pone.0009902
Shuttleworth, S. J., Bailey, S. G., & Townsend, P. A. (2010). Histone Deacetylase inhibitors: New promise in the treatment of immune and inflammatory diseases. Current Drug Targets, 11(11), 1430-1438.
Barry, S. P., & Townsend, P. A. (2010). What Causes a Broken Heart-Molecular Insights into Heart Failure. International Review of Cell and Molecular Biology, 284(C), 113-179. https://doi.org/10.1016/S1937-6448(10)84003-1
2009
Zeidan, B. A., Cutress, R. I., Hastie, C., Mirnezami, A. H., Packham, G., & Townsend, P. A. (2009). SELDI-TOF MS proteomics in breast cancer. Clinical Proteomics, 5(3-4), 133-147. https://doi.org/10.1007/s12014-009-9032-5
Sharp, A., Cutress, R. I., Johnson, P. W. M., Packham, G., & Townsend, P. A. (2009). Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth. FEBS Letters, 583(21), 3405-3411. https://doi.org/10.1016/j.febslet.2009.09.047
Kuizon, E., Pearce, E. G., Bailey, S. G., Chen-Scarabelli, C., Yuan, Z., Abounit, K., ... Scarabelli, T. M. (2009). Mechanisms of action and clinical implications of cardiac urocortin: A journey from the heart to the systemic circulation, with a stopover in the mitochondria. International Journal of Cardiology, 137(3), 189-194. https://doi.org/10.1016/j.ijcard.2009.03.112
Sharp, A., Crabb, S. J., Johnson, P. W. M., Hague, A., Cutress, R., Townsend, P. A., ... Packham, G. (2009). Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions. Journal of Pharmacology and Experimental Therapeutics, 331(2), 680-689. https://doi.org/10.1124/jpet.109.153601
Barry, S. P., Townsend, P. A., McCormick, J., Knight, R. A., Scarabelli, T. M., Latchman, D. S., & Stephanou, A. (2009). STAT3 deletion sensitizes cells to oxidative stress. Biochemical and Biophysical Research Communications, 385(3), 324-329. https://doi.org/10.1016/j.bbrc.2009.05.051
Zeidan, B. A., Cutress, R. I., Murray, N., Coulton, G. R., Hastie, C., Packham, G., & Townsend, P. A. (2009). Proteomic analysis of archival breast cancer serum. Cancer Genomics and Proteomics, 6(3), 141-148.
Davidson, S. M., Rybka, A. E., & Townsend, P. A. (2009). The powerful cardioprotective effects of urocortin and the corticotropin releasing hormone (CRH) family. Biochemical Pharmacology, 77(2), 141-150. https://doi.org/10.1016/j.bcp.2008.08.033
Townsend, P., Slater-Jefferiesa1, J., Phillipsa1, E., Lillycropa1, K., Legga1, G., Townsenda1, P., ... Burdgea1, G. (2009). Maternal diet alters expression of specific PPARα transcripts in the hearts of their female offspring. Proceedings of the Nutrition Society, 67(E355). https://doi.org/10.1017/S0029665108000293
Shuttleworth, S., Silva, F., Tomassi, C., Cecil, A., Hill, T., Rogers, H., & Townsend, P. (2009). Progress in the design and development of phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of chronic diseases. Progress in Medicinal Chemistry, 48, 81-131. https://doi.org/10.1016/S0079-6468(09)04803-6
2008
Crabb, S. J., Howell, M., Rogers, H., Ishfaq, M., Yurek-George, A., Carey, K., ... Packham, G. (2008). Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A. Biochemical Pharmacology, 76(4), 463-475. https://doi.org/10.1016/j.bcp.2008.06.004
Zeidan, B. A., & Townsend, P. A. (2008). SELDI-TOF proteomic profiling of breast carcinomas identifies clinicopathologically relevant groups of patients similar to previously defined clusters from cDNA expression. Breast Cancer Research, 10(3), [107]. https://doi.org/10.1186/bcr2107
Soond, S. M., Townsend, P. A., Barry, S. P., Knight, R. A., Latchman, D. S., & Stephanou, A. (2008). ERK and the F-box protein βTRCP target STAT1 for degradation. Journal of Biological Chemistry, 283(23), 16077-16083. https://doi.org/10.1074/jbc.M800384200
Scarabelli, T. M., Townsend, P. A., Chen Scarabelli, C., Yuan, Z., McCauley, R. B., Di Rezze, J., ... Stephanou, A. (2008). Amino Acid Supplementation Differentially Modulates STAT1 and STAT3 Activation in the Myocardium Exposed to Ischemia/Reperfusion Injury. American Journal of Cardiology, 101(11), S63-S68. https://doi.org/10.1016/j.amjcard.2008.03.003
Knight, R. A., Chen-Scarabelli, C., Yuan, Z., McCauley, R. B., Di Rezze, J., Scarabelli, G. M., ... Scarabelli, T. M. (2008). Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury. FEBS Letters, 582(6), 984-990. https://doi.org/10.1016/j.febslet.2008.02.035
Tare, R. S., Townsend, P. A., Packham, G. K., Inglis, S., & Oreffo, R. O. C. (2008). Bcl-2-associated athanogene-1 (BAG-1): A transcriptional regulator mediating chondrocyte survival and differentiation during endochondral ossification. Bone, 42(1), 113-128. https://doi.org/10.1016/j.bone.2007.08.032
Barry, S. P., Davidson, S. M., & Townsend, P. A. (2008). Molecular regulation of cardiac hypertrophy. International Journal of Biochemistry and Cell Biology, 40(10), 2023-2039. https://doi.org/10.1016/j.biocel.2008.02.020
2007
Townsend, P. A., Davidson, S. M., Clarke, S. J., Khaliulin, I., Carroll, C. J., Scarabelli, T. M., ... Halestrap, A. P. (2007). Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress. American Journal of Physiology - Heart and Circulatory Physiology, 293(2), H928-H938. https://doi.org/10.1152/ajpheart.01135.2006
Soond, S. M., Carroll, C., Townsend, P. A., Sayan, E., Melino, G., Behrmann, I., ... Stephanou, A. (2007). STAT1 regulates p73-mediated Bax gene expression. FEBS Letters, 581(6), 1217-1226. https://doi.org/10.1016/j.febslet.2007.02.049
Barry, S. P., Townsend, P. A., Latchman, D. S., & Stephanou, A. (2007). Role of the JAK-STAT pathway in myocardial injury. Trends in Molecular Medicine, 13(2), 82-89. https://doi.org/10.1016/j.molmed.2006.12.002
Townsend, P. (2007). In the news. Blood test could detect breast cancer. TrAC Trends in Analytical Chemistry, 26(10), 8. https://doi.org/10.1016/j.trac.2007.09.012).
Townsend, P.A.., Packham, G., Rogers, H., Habens, F., Cecil, ARL., Hill, T., & Ganesan, A. (2007). Novel synthetic analogues of the natural product histone deacetylase inhibitor FK2286289. 3428S. Molecular Cancer Therapeutics.
Townsend, P. A., Lambrianides, A., Carroll, C. J., Pericleous, C., Heywood, W., Mills, K., ... Giles, U. (2007). Purified IgG from patients with different clinical manifestations of the antiphospholipid syndrome have differential effects upon the NF-kappa B and p38MAPK signalling pathways in monocytes. Rheumatology, 46(Supp 1), p.i79. https://doi.org/10.1093/rheumatology/kem1020
Townsend, P.A.., Crabb, SJ., Davidson, SM., Johnson, PWM., Packham, G., Ganesan, A., ... Wess, G. (Ed.) (2007). The bicyclic depsipeptide family of histone deacetylase inhibitors. Chemical Biology (1 ed., pp. 693-720)
Townsend, P.A.., Cutress, RI., Crabb, SJ., Sharp, A., Packham, G., & Yao, A. P. (Ed.) (2007). The significance and function of BAG-1 in breast cancer. In New Developments in Breast Cancer Research: Horizons in Cancer Research (pp. 1-30). USA: Nova Science Publishers.
2006
McCormick, J., Barry, S. P., Sivarajah, A., Stefanutti, G., Townsend, P. A., Lawrence, K. M., ... Stephanou, A. (2006). Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20(12). https://doi.org/10.1096/fj.06-6188fje
Valentim, L., Laurence, K. M., Townsend, P. A., Carroll, C. J., Soond, S., Scarabelli, T. M., ... Stephanou, A. (2006). Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. Journal of Molecular and Cellular Cardiology, 40(6), 846-852. https://doi.org/10.1016/j.yjmcc.2006.03.428
Scarabelli, T. M., Knight, R., Stephanou, A., Townsend, P., Chen-Scarabelli, C., Lawrence, K., ... Narula, J. (2006). Clinical implications of apoptosis in ischemic myocardium. Current Problems in Cardiology, 31(3), 181-264. https://doi.org/10.1016/j.cpcardiol.2005.11.002
Tare, RS., Townsend, P.A.., Packham, G., & Oreffo, ROC. (2006). Insight into the function of Bcl-2-associated athanogene-1 anti-apoptotic protein during chondrocyte development and differentiation. Journal of Bone and Mineral Research, 21(7), 1150-1151.
Townsend, P., Jeffic, D., Abboud, J., Almanaseer, Y., Jabaren, M., Gardin, J., ... Scaralbelli, T. (2006). Myocyte bag-1 provides endogenous cardioprotection following relocation from the cytoplasm to the nuclei in the rat heart exposed to in-vivo ischemia/reperfusion injury. Journal of the American College of Cardiology, 47(4). https://doi.org/10.1016-j.jacc.2006.01.014
2005
Lawrence, K. M., Kabir, A. M. N., Bellahcene, M., Davidson, S., Cao, X. B., McCormick, J., ... Latchman, D. S. (2005). Cardioprotection mediated by urocortin is dependent on PKCε activation. FASEB Journal, 19(7), 831-833. https://doi.org/10.1096/fj.04-2506fje
Townsend, P. A., Cragg, M. S., Davidson, S. M., McCormick, J., Barry, S., Lawrence, K. M., ... Stephanou, A. (2005). STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. Journal of Cell Science, 118(8), 1629-1639. https://doi.org/10.1242/jcs.01728
Chanalaris, A., Lawrence, K. M., Townsend, P. A., Davidson, S., Jashmidi, Y., Stephanou, A., ... Latchman, D. S. (2005). Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochemical and Biophysical Research Communications, 328(2), 442-448. https://doi.org/10.1016/j.bbrc.2005.01.001
Townsend, P. A., Stephanou, A., Packham, G., & Latchman, D. S. (2005). BAG-1: A multi-functional pro-survival molecule. International Journal of Biochemistry and Cell Biology, 37(2), 251-259. https://doi.org/10.1016/j.biocel.2004.03.016
Davidson, S. M., Townsend, P. A., Carroll, C., Yurek-George, A., Balasubramanyam, K., Kundu, T. K., ... Latchman, D. S. (2005). The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. ChemBioChem: 6(1), 162-170. https://doi.org/10.1002/cbic.200400246
Townsend, P., Chen-Scarabelli, C. A., Angeles, R., Allebban, Z., Ama, R., Abboud, J., ... Scarabelli, T. M. (2005). Cardiac release of urocortin is independent from the occurrence of irreversible myocardial damage in the intact rat heart exposed to ischemia/reperfusion injury: A potential clinical marker of sublethal myocardial ischemia? Circulation, 112(17), p.U202.
Townsend, P., Chen-Scarabelli, C., Angeles, R., Allebban, Z., Abboud, J., Ama, R., ... Scarabelli, M. (2005). Col-3 A chemically midified tetracycline lacking anti-microbial activity - Provides cardiproprotection against ischemia/reperfusion injury reducint mitochondrial relocation of cytoplasmic cofilin and enhancing the ratio of Xiap to Smac/DIABLO6. u214. Circulation
Townsend, P., Packham, G., Barry, S., Chen-Scarabelli, C., Raddino, R., Knight, R., ... Scarabelli, TM. (2005). Cytoplasmic/nuclear relocation of myocyte BAG-1 provides endogenous cardiprotection in the intact rat heart exposed to ischemia/reperfusion injury. u1195. Circulation
Townsend, P., Cost, A., Pivtoraiko, V., Garlid, K., Angeles, R., Allebban, Z., ... Scarabelli, TM. (2005). Urocortin induces Pkc-epsilon-mediated opening of mitochondrial K-Atp channels in isolated heart mitochondria. u65. Circulation
2004
Munarriz, E., Barcaroli, D., Stephanou, A., Townsend, P. A., Maisse, C., Terrinoni, A., ... De Laurenzi, V. (2004). PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Molecular and Cellular Biology, 24(24), 10593-10610. https://doi.org/10.1128/MCB.24.24.10593-10610.2004
Townsend, P. A., Scarabelli, T. M., Pasini, E., Gitti, G., Menegazzi, M., Suzuki, H., ... Stephanou, A. (2004). Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. Faseb Journal, 18(13), 1621-1623. https://doi.org/10.1096/fj.04-1716fje
Scarabelli, T. M., Pasini, E., Ferrari, G., Ferrari, M., Stephanou, A., Lawrence, K., ... Gardin, J. M. (2004). Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells. Journal of Thoracic and Cardiovascular Surgery, 128(3), 364-371. https://doi.org/10.1016/j.jtcvs.2003.11.028
Lawrence, K. M., Townsend, P. A., Davidson, S. M., Carroll, C. J., Eaton, S., Hubank, M., ... Latchman, D. S. (2004). The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage. Biochemical and Biophysical Research Communications, 321(2), 479-486. https://doi.org/10.1016/j.bbrc.2004.06.170
Townsend, P. A., Cutress, R. I., Carroll, C. J., Lawrence, K. M., Scarabelli, T. M., Packham, G., ... Latchman, D. S. (2004). BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome. Journal of Biological Chemistry, 279(20), 20723-20728. https://doi.org/10.1074/jbc.M400399200
Sharp, A., Crabb, S. J., Townsend, P. A., Cutress, R. I., Brimmell, M., Wang, X. H., & Packham, G. (2004). BAG-1 in carcinogenesis. Expert Reviews in Molecular Medicine, 6(7). https://doi.org/10.1017/S1462399404007537
Townsend, P. A., Scarabelli, T. M., Davidson, S. M., Knight, R. A., Latchman, D. S., & Stephanou, A. (2004). STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis. Journal of Biological Chemistry, 279(7), 5811-5820. https://doi.org/10.1074/jbc.M302637200
Scarabelli, TM., Stephanou, A., Pasini, E., Gitti, G., Townsend, P.A.., Lawrence, K., ... Gardin, J. (2004). Minocycline inhibits caspase activation and ractivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C an smac/DIABLO. Journal of the American College of Cardiology, 43(5), 865-874.
Parkinson, EJ., Townsend, P.A.., Staphanou, A., Latchman, DS., Eaton, S., & Pierro, A. (2004). The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is assoicated with modifiction of hepatic transcription factor activation. J Pediatr Surgery, 6(7), 696-701.
2003
Lawrence, K. M., Scarabelli, T. M., Turtle, L., Chanalaris, A., Townsend, P. A., Carroll, C. J., ... Latchman, D. S. (2003). Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression. Faseb Journal, 17(15), 2313-2315. https://doi.org/10.1096/fj.02-0832fje
Arhel, N. J., Packham, G., Townsend, P. A., Collard, T. J., H-Zadeh, A. M., Sharp, A., ... Williams, A. C. (2003). The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines. International Journal of Cancer, 106(3), 364-371. https://doi.org/10.1002/ijc.11257
Cutress, R. I., Townsend, P. A., Sharp, A., Maison, A., Wood, L., Lee, R., ... Packham, G. (2003). The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription. Oncogene, 22(32), 4973-4982. https://doi.org/10.1038/sj.onc.1206688
Townsend, P. A., Cutress, R. I., Sharp, A., Brimmell, M., & Packham, G. (2003). BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway. Cancer Research, 63(14), 4150-4157.
Townsend, P. A., Cutress, R. I., Sharp, A., Brimmell, M., & Packham, G. (2003). BAG-1: A multifunctional regulator of cell growth and survival. Biochimica et Biophysica Acta - Reviews on Cancer, 1603(2), 83-98. https://doi.org/10.1016/S0304-419X(03)00002-7
Packham, G., Cuttress, RI., Townsend, P.A.., Sharp, A., & Johnson, PWM. (2003). BAG-1 potentiates oestrogen dependent transcription and protect breast cancer cells from stress-induced growth inhibition. British Journal of Cancer, 88(supp 1), S59. https://doi.org/10.1038/sj.bjc.6600375
2002
Cutress, R. I., Townsend, P. A., Brimmell, M., Bateman, A. C., Hague, A., & Packham, G. (2002). Bag-1 expression and function in human cancer. British Journal of Cancer, 87(8), 834-839. https://doi.org/10.1038/sj.bjc.6600538
Lawrence, K. M., Chanalaris, A., Scarabelli, T., Hubank, M., Pasini, E., Townsend, P. A., ... Latchman, D. S. (2002). K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect. Circulation, 106(12).
Townsend, P. A., Dublin, E., Hart, I. R., Kao, R. H., Hanby, A. M., Cutress, R. I., ... Packham, G. (2002). BAG-1 expression in human breast cancer: Interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data. Journal of Pathology, 197(1), 51-59. https://doi.org/10.1002/path.1081
Cuttress, RI., Townsend, P.A.., Wood, L., Brimmell, M., Maison, A., Lee, R., ... Packham, G. (2002). Nuclear BAG-1 expression predicts survival from breast cancer, and potentiates oestrogen dependent transcription. British Journal of Cancer, 86(supp 1), S32. https://doi.org/10.1038/sj.bjc.660046
Stephanou, A., Scarabelli, TM., Townsend, P.A.., Bell, R., Yellon, D., Knight, RA., & Latchman, DS. (2002). The carboxylterminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes. FASEB J, 16(13), 1841-1843.
2001
Cutress, R. I., Townsend, P. A., Bateman, A. C., Johnson, P. W. M., Ryder, K., Barnes, D. M., ... Reed, J. C. (2001). BAG-1 immunostaining and survival in early breast cancer [1] (multiple letters). Journal of Clinical Oncology, 19(16), 3706-3707.
Townsend, P.A.., Lewis, CA., & Isacke, CM. (2001). Ca(2+)/calmodulin-dependent protein kinase mediates the phosphorlyation of CD44 required for cell migration on hyaluronan. Biochemical Journal, 357(pt 3), 843-850.
Townsend, P.A.., Cuttress, R., Brimmell, M., & Packham, G. (2001). Molecular analysis of BAG-1 function in human breast cancer cells. British Journal of Cancer, 85(supp 1), 23. https://doi.org/10.1054/bjoc.2001.1917
2000
MacCarthy-Morrogh, L., Townsend, P. A., Purohit, A., Hejaz, H. A. M., Potter, B. V. L., Reed, M. J., & Packham, G. (2000). Differential effects of estrone and estrone-3-O-sulfamate derivatives on mitotic arrest, apoptosis, and microtubule assembly in human breast cancer cells. Cancer Research, 60(19), 5441-5450.
Townsend, P. A., Villanova, I., Uhlmann, E., Peyman, A., Knolle, J., Baron, R., ... Horton, M. A. (2000). An antisense oligonucleotide targeting the alphaV integrin gene inhibits adhesion and induces apoptosis in breast cancer cells. European Journal of Cancer (Oxford, England : 1990), 36(3).
1999
MacCarthy-Morrogh, L., Mouzakiti, A., Townsend, P. A., Brimmell, M., & Packham, G. (1999). Bcl-2-related proteins and cancer. Biochemical Society Transactions, 27(6), 785-9.
Townsend, P. A., Villanova, I., Teti, A., & Horton, M. A. (1999). Beta1 integrin antisense oligodeoxynucleotides: utility in controlling osteoclast function. European Journal of Cell Biology, 78(7).
Villanova, I., Townsend, P. A., Uhlmann, E., Knolle, J., Peyman, A., Amling, M., ... Teti, A. (1999). Oligodeoxynucleotide targeted to the α(v) gene inhibits α(v) integrin synthesis, impairs osteoclast function, and activates intracellular signals to apoptosis. Journal of Bone and Mineral Research, 14(11), 1867-1879. https://doi.org/10.1359/jbmr.1999.14.11.1867
1992
- Hall, I. P., Widdop, S., Townsend, P., & Daykin, K. (1992). Control of cyclic AMP levels in primary cultures of human tracheal smooth muscle cells. British Journal of Pharmacology, 107(2), 422-428.
Journal Letters
Cutress, R.I., Townsend, P.A., Bateman, A.C., Johnson, P.W.M., Ryder, K., Barnes, D.M. and Packham, G. Letter on “BAG-1 immunostaining and survival in early breast cancer”. Journal of Clinical Oncology 19; (2001) pp3706-3707.
Books - Short Works
2018
Larkin, S.E.T., Abbott, B., Brown, M.D., Clarke, N.W., Jackson, T.R. and Townsend, P.A. Proteomics in Prostate Cancer Research. In “Precision Molecular Pathology of Prostate Cancer” Published by Springer (Editors, Robinson, B.D and Mosquera, J.M.)
2010
Scott, P.A., Morgan, J.M. and Townsend, P.A. Sudden cardiac death risk stratification in heart failure – the potential role of biomarkers. In “Cardiomyopathies: Causes, Effects and Treatment.” Published by Nova Science Publishers, Inc. (Editor, Wright, M.S.)
2008
Rybka, A.E, Stephanou, A. and Townsend, P.A. Janus Kinase (JAK)‑Signal Transducer and Activator of Transcription (STAT) Pathway in Heart Disease. In “JAK-STAT Pathway in Disease” Published by LandesBiosciences (Editor, Stephanou, A)
2007
Townsend, P.A. Crabb, S.J., Davidson, S.M., Johnson, P.W.M., Packham, G., Ganesan A: The Bicyclic Depsipeptide Family of Histone Deacetylase Inhibitors. In: Chemical Biology: From Small Molecules to Systems Biology and Drug Design. Edited by Schreiber S, Kapoor TM, Wess G: 693-725, Wiley-VCH
2004
Cutress, R.I., Crabb, S.J., Sharp, A., Townsend, P.A., and Packham G. The significance and function of BAG-1 in breast cancer. In: Progress in Breast Cancer Research (Columbus F Ed.). Pages 1-30
1996
Horton, M.A., Townsend, P.A., and Nesbitt, S.A. Cell surface attachment molecules in bone. From: Principles In Bone Biology (Blezikian, Raisz, and Rodan, Eds) 217-229, Academic Press (London)