Translational sleep and circadian research

We conduct a range of studies that applies sleep medicine and circadian biology principles to improve sleep and circadian rhythms in real-world environments.


Our studies include lighting interventions to improve workplace alertness, safety and performance; occupational sleep disorders screening and referral programmes in 24/7 safety-sensitive operations such as police and fire services; and application of mathematical models of alertness and fatigue to design safer shift schedules for the transportation industry.

We have worked with a number of pharmaceutical companies in Phase I to IV clinical trials to investigate the impact of a wide range of novel and marketed compounds on sleep structure and quality, as well as investigating the impact of the time of day of dosing on clinical outcomes.

Current research projects

Selected publications

Revell VL, della Monica C, Mendis J, Hassanin H, Halter RJ, Chaplan SR, Dijk DJ. Effects of the selective orexin-2 receptor antagonist JNJ-48816274 on sleep initiated in the circadian wake maintenance zone: a randomised trial. Neuropsychopharmacology. 2021 Oct 9. doi: 10.1038/s41386-021-01175-3. Epub ahead of print. PMID: 34628482.

Arbon EL, Knurowska M, Dijk DJ. Randomised clinical trial of the effects of prolonged-release melatonin, temazepam and zolpidem on slow-wave activity during sleep in healthy people. J Psychopharmacol. 2015 Jul;29(7):764-76. doi: 10.1177/0269881115581963. Epub 2015 Apr 28. PMID: 25922426.

Eastell R, Dijk DJ, Small M, Greenwood A, Sharpe J, Yamada H, Yuba M, Tanimoto M, Deacon S. Morning vs evening dosing of the cathepsin K inhibitor ONO-5334: effects on bone resorption in postmenopausal women in a randomized, phase 1 trial. Osteoporos Int. 2016 Jan;27(1):309-18. doi: 10.1007/s00198-015-3342-4. Epub 2015 Oct 7. PMID: 26446770; PMCID: PMC4715857.

View all our selected publications